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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, ethyl ester

RTECS #

AH5425000

CAS #

141-78-6

Updated

October 2015

Molecular Weight

88.12

Molecular Formula

C4H8O2

Synonyms

Acetic ether
Acetidin
Acetoxyethane
Aethylacetat (German)
Essigester (German)
Ethyl acetate
Ethyl acetate (ACGIH:OSHA)
Ethyl acetic ester
Ethyl ethanoate
Ethylacetaat (Dutch)
Ethyle (acetate d') (French)
Ethylester kyseliny octove (Czech)
Etile (acetato di) (Italian)
Octan etylu (Polish)
RCRA waste number U112
Vinegar naphtha

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 400 ppmJIHTAB 25,282,1943

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster9 gm/LFCTOD7 22,623,1984
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae24400 ppmMUREAV 149,339,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 359 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1855,2013
inhalation/cat Lowest published lethal concentration: 61 gm/m3HBTXAC 1,336,1955
inhalation/human lowest published toxic concentration: 400 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation/mouse lethal concentration (50 percent kill): 45 gm/m3/2H85GMAT -,65,1982
inhalation/mouse lowest published toxic concentration: 200 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/rat lethal concentration (50 percent kill): 200 gm/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
SRTCAC 36(1-4),10,1989
inhalation/rat lethal concentration (50 percent kill): 1600 ppm/8HENTOX* -,277,2005
inhalation/rat lethal concentration (50 percent kill): >6000 ppm/6HENTOX* -,277,2005
intraperitoneal/mouse lethal dose (50 percent kill): 709 mg/kgSCCUR* -,5,1961
oral/guinea pig lethal dose (50 percent kill): 5.5 gm/kgENTOX* -,277,2005
oral/guinea pig lethal dose (50 percent kill): 5500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
GISAAA 48(4),66,1983
oral/mouse lethal dose (50 percent kill): 4100 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
GISAAA 48(4),66,1983
oral/mouse lethal dose (50 percent kill): 4.1 gm/kgENTOX* -,277,2005
oral/rabbit lethal dose (50 percent kill): 4935 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 5620 mg/kgYKYUA6 32,1241,1981
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 10/4/1968
subcutaneous/cat lethal dose (50 percent kill): 3 gm/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Blood: Other changes
AGGHAR 5,1,1933
subcutaneous/guinea pig lethal dose (50 percent kill): 3 gm/kgBehavioral: Somnolence (general depressed activity)AGGHAR 5,1,1933
subcutaneous/rat lowest published lethal dose: 5 gm/kgBSIBAC 18,45,1943

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 22 gm/m3/40M/4W- intermittentBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0572401
inhalation/rat lowest published toxic concentration: 1500 ppm/90D- intermittentOlfaction: Change in sensation of smell

Olfaction: Other olfaction effects
TOPADD 27,618,1999
intraperitoneal/rat lowest published toxic dose: 8 mL/kg/8D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other carbohydrates
BECTA6 12,612,1974

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 400 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMIHAB 21,28,1960
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWENTOX* -,277,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,292,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 400 ppm (1400 mg/m3)DTLVS* 3,102,1971
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (720 mg/m3), short term exposure limit 400 ppm (1440 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 300 ppm (1050 mg/m3);KZW 600 ppm (2100 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 400 ppm (1461 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (540 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 300 ppm (1100 mg/m3), short term exposure limit 500 ppm (1800 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 400 ppm (1400 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 400 ppm (1.5 gm/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1400 mg/m3, short term exposure limit 1400 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (540 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (720 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 400 ppm (1400 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 400 ppm (1400 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (720 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 150 ppm (550 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 400 ppm (1441 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 ppm, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 50 mg/m3, short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 150 ppm (500 mg/m3);short term exposure limit 300 ppm (1100 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 400 ppm (1400 mg/m3), KZG-week 800 ppm (2800 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 550 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm;short term exposure limit 400 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 400 ppm (1400 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 400 ppm (1400 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 400 ppm (1400 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 400 ppm (1400 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACETATE-air10H time-weighted average 400 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 31470; Number of Industries 234; Total Number of Facilities 40728; Number of Occupations 154; Total Number of Employees Exposed 504448; Total Number of Female Employees Exposed 119505
National Occupational Hazard Survey 1974Hazard Code 31470; Number of Industries 234; Total Number of Facilities 37072; Number of Occupations 152; Total Number of Employees Exposed 407816

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl acetate, 1457
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
On EPA IRIS database
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