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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, butyl ester

RTECS #

AF7350000

CAS #

123-86-4

Updated

October 2014

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

1-Butyl acetate
Acetate de butyle (French)
Acetic acid n-butyl ester
Butile (acetati di) (Italian)
Butyl acetate (OSHA)
Butyl ethanoate
Butylacetat (German)
Butylacetaten (Dutch)
Butyle (acetate de) (French)
Butylester kyseliny octove (Czech)
n-Butyl acetate
n-Butyl acetate (ACGIH:OSHA)
Octan n-butylu (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 300 ppmJIHTAB 25,282,1943
eye /rabbit 100 mg moderateATDAEI 1,196,1992
skin /rabbit 500 mg/24H moderateFCTXAV 17,515,1979

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1500 ppm/7H (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB83-258038
inhalation/rat 1500 ppm (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JAPTO* 27,32,2007
inhalation/rat 1500 ppm (21D pre-16D pregnant)Reproductive: Other effects on femaleHPV112 -,-,2008
inhalation/rabbit 1500 ppm (1-19D pregnant)Reproductive: Other effects on femaleHPV112 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 68 gm/m3/72MBehavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Emphysema
AGGHAR 5,1,1933
inhalation/guinea pig Lowest published lethal concentration: 67 gm/m3/4HEye: Other eye effects

Behavioral: Antipsychotic
FCTXAV 17,515,1979
inhalation/human lowest published toxic concentration: 200 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 40 gm/m3GTPZAB 32(10),25,1988
inhalation/mouse lethal concentration (50 percent kill): 6 gm/m3/2HYKYUA6 32,1241,1981
inhalation/rat lethal concentration (50 percent kill): 390 ppm/4HBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
INHTE5 9,623,1997
intramuscular/guinea pig lowest published lethal dose: 2648 mg/kgBehavioral: Muscle weaknessJPETAB 76,189,1942
intraperitoneal/guinea pig lowest published lethal dose: 1500 mg/kgLiver: Fatty liver degeneration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
AIHAAP 35,21,1974
intraperitoneal/mouse lethal dose (50 percent kill): 1230 mg/kgSCCUR* -,2,1961
oral/guinea pig lethal dose (50 percent kill): 4700 mg/kg85GMAT -,28,1982
oral/mammal (species unspecified) lethal dose (50 percent kill): 4300 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 6 gm/kgGTPZAB 25(11),57,1981
oral/rabbit lethal dose (50 percent kill): 3200 mg/kg85GMAT -,28,1982
oral/rat lethal dose (50 percent kill): 10768 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
ATDAEI 1,196,1992
skin/rabbit lethal dose (50 percent kill): >17600 mg/kgNPIRI* 1,7,1974
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1592 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 36(1 Pt2),61,1997
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight

Endocrine: Changes in adrenal weight
FCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/13W- continuousBrain and Coverings: Changes in brain weight

Endocrine: Changes in spleen weight

Endocrine: Changes in adrenal weight
FCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/13W- continuousBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/13W- continuousOlfaction: Other olfaction effectsFCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/30D- continuousNutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: Cl
FCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/30D- continuousNutritional and Gross Metabolic: Changes in: NaFCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 1500 ppm/6H/90D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: DehydrogenasesFCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/90D- continuousBlood: Changes in erythrocyte (RBC) countFCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/90D- continuousBlood: Changes in erythrocyte (RBC) count

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 39,877,2001
inhalation/rat lowest published toxic concentration: 83.8 gm/kg/13W- intermittentBehavioral: Somnolence (general depressed activity)

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 66,101,2002
inhalation/rat : 2000 ppm/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 27,32,2007
inhalation/rat : 1000 ppm/7D- intermittentBehavioral: Food intake (animal)JAPTO* 27,32,2007
inhalation/rat lowest published toxic concentration: 1500 ppm/13W- intermittentOlfaction: Other olfaction effects

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV112 -,-,2008
inhalation/rat lowest published toxic concentration: 3000 ppm/14W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV112 -,-,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 150 ppm;short term exposure limit 200 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMIHAB 21,28,1960
TOXICOLOGY REVIEWMUREAV 564,179,2004
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWTOLED5 199,203,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 150 ppm (700 mg/m3)DTLVS* 3,30,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 150 ppm (713 mg/m3), short term exposure limit 200 ppm (950 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 150 ppm(723 mg/m3), short term exposure limit 200 ppm(964 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 150 ppm (710 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 150 ppm (720 mg/m3), short term exposure limit 200 ppm (960 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 150 ppm (710 mg/m3), VLE 200 ppm (940 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (480 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 950 mg/m3, short term exposure limit 950 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 150 ppm (700 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (475 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 150 ppm (710 mg/m3), short term exposure limit 200 ppm (950 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 150 ppm (710 mg/m3);short term exposure limit 200 ppm (950 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 150 ppm (713 mg/m3); short term exposure limit 200 ppm (950 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 75 ppm (355 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 150 ppm (713 mg/m3); short term exposure limit 200 ppm (950 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 950 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 50 mg/m3, short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 100 ppm (500 mg/m3);short term exposure limit 150 ppm (700 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (480 mg/m3), KZG-week 200 ppm (960 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 710 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 150 ppm (710 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 150 ppm (710 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 150 ppm (724 mg/m3);short term exposure limit 200 ppm (966 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 150 ppm (710 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 150 ppm (710 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 150 ppm (710 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 150 ppm (710 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL ACETATE-air10H time-weighted average 150 ppm;short term exposure limit 200 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 14380; Number of Industries 271; Total Number of Facilities 55011; Number of Occupations 164; Total Number of Employees Exposed 822099; Total Number of Female Employees Exposed 143606
National Occupational Hazard Survey 1974Hazard Code 14380; Number of Industries 280; Total Number of Facilities 52224; Number of Occupations 153; Total Number of Employees Exposed 527992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
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