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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetamide, N,N-dimethyl-

RTECS #

AB7700000

CAS #

127-19-5

Updated

July 2016

Molecular Weight

87.14

Molecular Formula

C4H9NO

Synonyms

Acetdimethylamide
Acetic acid, dimethylamide
Dimethyl acetamide (ACGIH:OSHA)
Dimethylacetamide
Dimethylacetone amide
Dimethylamid kyseliny octove (Czech)
Dimethylamide acetate
DMA
DMAc
N,N-Dimethylacetamide
NSC 3138
U-5954

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildDCTODJ 9,147,1986
skin /rabbit 10 mg/24H open irritation test mildAIHAAP 23,95,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionunreported route/mouse4400 mg/kgAPHGAO 56,97,1986
sister chromatid exchangeovary/hamster10 gm/LAPHGAO 56,97,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 288 ppm/6H (10D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTOXID9 4,65,1984
inhalation/rat 281 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 29(2),59A,1984
inhalation/rat 300 ppm/6H (10W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 7,132,1986
inhalation/rat 282 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 16,414,1991
inhalation/rat 282 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
CRTXB2 31,139,2001
inhalation/rabbit 570 ppm (7-19D pregnant)Reproductive: Other effects to embryo or fetusCRTXB2 31,139,2001
intraperitoneal/rat 2 mg/kg (1D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
85DJA5 -,95,1971
oral/rabbit 3900 mg/kg (6-18D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 30,1557,1980
oral/rabbit 3900 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ARZNAD 30,1557,1980
oral/rat 5600 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
FAATDF 9,550,1987
oral/rat 5600 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Homeostasis
FAATDF 9,550,1987
oral/rat 5600 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
CRTXB2 31,139,2001
oral/rat 2240 mg/kg (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
CRTXB2 31,139,2001
oral/rat 5600 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
CRTXB2 31,139,2001
oral/rat 6 gm/kg (7-21D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
CRTXB2 31,139,2001
skin/rat 2400 mg/kg (10-11D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
TXAPA9 41,35,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jzxInhibitor Concentration (50 percent kill): 14.5 pph/60MIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,150,2012
inhalation/mammal (species unspecified) Lowest published lethal concentration: 406 ppmLiver: Fatty liver degenerationTXAPA9 3,12,1961
inhalation/mouse lethal concentration (50 percent kill): 7200 mg/m3Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
CHYCDW 13,29,1979
inhalation/rat lethal concentration (50 percent kill): 2475 ppm/1HNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 9,147,1986
intraperitoneal/mouse lethal dose (50 percent kill): 2800 mg/kgYKIGAK 31,327,1980
intraperitoneal/rat lethal dose (50 percent kill): 2750 mg/kgJRPFA4 4,219,1962
intravenous/chicken lowest published lethal dose: 12 gm/kgARZNAD 20,1242,1970
intravenous/mouse lethal dose (50 percent kill): 3020 mg/kgARZNAD 26,1581,1976
intravenous/rabbit lowest published lethal dose: 8340 mg/kgARZNAD 20,1242,1970
intravenous/rat lethal dose (50 percent kill): 2640 mg/kgARZNAD 26,1581,1976
oral/mouse lethal dose (50 percent kill): 4620 mg/kgARZNAD 26,1581,1976
oral/rat lethal dose (50 percent kill): 4300 mg/kgGISAAA 45(6),76,1980
skin/mouse lethal dose (50 percent kill): 9600 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
CHYCDW 13,29,1979
skin/rabbit lethal dose (50 percent kill): 2240 mg/kgSkin: After topical application: Primary irritationAIHAAP 23,95,1962
skin/rat lethal dose (50 percent kill): >2 gm/kgEPASR* 8EHQ-1190-0981
unreported route/rat lethal dose (50 percent kill): 3 gm/kgARZNAD 19,1073,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 700 mg/m3/4H/2W- intermittentBlood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INHTE5 9,141,1997
inhalation/mouse lowest published toxic concentration: 375 ppm/6H/78W- intermittentEye: Retinal changes pigmentary deposition, retinitis, other)

Liver: Other changes

Liver: Changes in liver weight
FAATDF 28,80,1995
inhalation/rat lowest published toxic dose: 103 ppm/6H/26W- intermittentLiver: Other changesTXAPA9 3,12,1961
inhalation/rat lowest published toxic concentration: 300 ppm/6H/12D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
DCTODJ 16,175,1993
inhalation/rat lowest published toxic concentration: 120 ppm/6H/64D- intermittentLiver: Changes in liver weightJTEHD6 27,297,1989
inhalation/rat lowest published toxic concentration: 100 ppm/6H/2Y- intermittentLiver: Other changesFAATDF 28,80,1995
oral/rat lowest published toxic dose: 15 gm/kg/10D- continuousGastrointestinal: Other changes

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0572893
oral/rat lowest published toxic dose: 364 mg/kg/26W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 45(6),76,1980
oral/rat lowest published toxic dose: 4500 mg/kg/90D- continuousBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
DCTODJ 9,147,1986
skin/Dog lowest published toxic dose: 113 gm/kg/6W- intermittentLiver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 3,12,1961
skin/rabbit lowest published toxic dose: 8 gm/kg/4D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 9,147,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (35 mg/m3) (skin)DTLVS* 3,88,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (36 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (36 mg/m3);KZW 20 ppm (72 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (36 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 20 ppm (72 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (35 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 36 mg/m3 (10 ppm);short term exposure limit 72 mg/m3 (20 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (36 mg/m3), short term exposure limit 20 ppm (72 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (7.2 mg/m3), VLE 10 ppm (36 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (36 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 36 mg/m3, short term exposure limit 72 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (36 mg/m3), short term exposure limit 20 ppm (72 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 ppm (36 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (35 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (35 mg/m3);short term exposure limit 15 ppm (50 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (36 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (36 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 35 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (35 mg/m3);short term exposure limit 20 ppm (70 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (35 mg/m3), KZG-week 20 ppm (70 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 36 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (36 mg/m3);short term exposure limit 20 ppm (72 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYL ACETAMIDE-air10H time-weighted average 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 26095; Number of Industries 14; Total Number of Facilities 907; Number of Occupations 27; Total Number of Employees Exposed 28943; Total Number of Female Employees Exposed 15028
National Occupational Hazard Survey 1974Hazard Code 26095; Number of Industries 5; Total Number of Facilities 66; Number of Occupations 13; Total Number of Employees Exposed 7658

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dimethylacetamide, 2004
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