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Registry of Toxic Effects of Chemical Substances (RTECS)

Zinc chloride

RTECS #

ZH1400000

CAS #

7646-85-7

Updated

October 2015

Molecular Weight

136.27

Molecular Formula

Cl2Zn

Synonyms

Butter of zinc
Chlorure de zinc (French)
Zinc (chlorure de) (French)
Zinc butter
Zinc chloride fume
Zinc chloride fume (ACGIH:OSHA)
Zinc dichloride
Zinco (cloruro di) (Italian)
Zinkchlorid (German)
Zinkchloride (Dutch)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 1%/5D open irritation test severeHBTME* ,925,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human300 µmol/LTXCYAC 10,67,1978
Cytogenetic AnalysisAscites tumor/rat700 mg/kgGANNA2 54,155,1963
Cytogenetic Analysisoral/mouse18 gm/kg/30D-continuousCRSBAW 176,563,1982
Cytogenetic Analysisintraperitoneal/mouse7.5 mg/kgHBTME* -,925,2007
DNA Damagefibroblast/human2 mmol/LMUREAV 193,237,1988
DNA inhibitionparenteral/mouse16 mg/kgCCCCAK 48,3020,1983
DNA inhibitionlymphocyte/human360 µmol/LIAAAAM 77,461,1985
host-mediated assaySalmonella typhimurium/mouse6 mg/kgSOGEBZ 13,1010,1977
micronucleus testlymphocyte/human100 mg/LTXAPA9 197,259,2004
micronucleus testother cell types/non-mammalian species170 µg/L/48HMUREAV 209,131,1988
morphological transformembryo/hamster100 nmol/L/7DARTODN 79,90,2005
morphological transformfibroblast/mouse10 mg/L/10DMUREAV 702,100,2010
morphological transformembryo/hamster180 µmol/LCNREA8 39,193,1979
mutation in microorganisms/Salmonella typhimurium25 mg/LTXAPA9 197,259,2004
mutation in microorganisms/Salmonella typhimurium90 mmol/L (-enzymatic activation step)SOGEBZ 13,1010,1977
other mutation test systemslymphocyte/human2 mgCRSBAW 176,563,1982
phage inhibition capacity/Escherichia coli3200 µmol/LENMUDM 6,59,1984
specific locus testoral/Drosophila melanogaster6 mmol/LMUREAV 320,133,1994
Unscheduled DNA Synthesislymphocyte/human180 µmol/LIAAAAM 77,461,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 20500 µg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 66,1755,1977
intraperitoneal/mouse 12500 µg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemDABBBA 36,6103,1975
intraperitoneal/rat 30 gm/kg (7-8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 29(3),23A,1984
intraperitoneal/mouse 50 mg(Zn)/kg (8-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HBTME* -,925,2007
intravaginal/rabbit 29184 µg/kg (1D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)CCPTAY 22,659,1980
oral/rat 1.8 gm/kg (98D male/98D pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Specific developmental abnormalities: Eye, ear
TOXID9 72,75,2003
oral/rat 7.1 gm/kg (98D male/98D pre-3W after birth)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)TOXID9 72,75,2003
oral/mouse 186 mg/kg (98D male/98D pre-3W after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 72,75,2003
oral/mouse 186 mg/kg (multigenerations)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)TOXID9 72,75,2003
oral/rat 1.8 gm/kg (98D male/98D pre-3W after birth)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 72,76,2003
oral/mouse 456 mg/kg (70D male/70D pre-21D after birth)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOXID9 1,110,2001
oral/mouse 456 mg/kg (70D male/70D pre-21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 1,110,2001
oral/rat 155 mg/kg (33D male)Reproductive: Other effects on male

Endocrine: Change in LH

Endocrine: Change in gonadotropins
JOENAK 79,151,1978
oral/rat 6 gm/kg (77D male/77D pre-21D after birth)Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 54,369,2000
parenteral/rat 37500 µg/kg (10D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)56ZJAL 5,722,1998

Tumorigenic Data and References

Route/OrganismDoseEffectReference
parenteral/chicken lowest published toxic dose: 15 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors
CANCAR 6,464,1953
parenteral/hamster lowest published toxic dose: 17 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
CNREA8 34,2612,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, fibroblast Inhibitor Concentration Low: 10 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 207,197,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 100 µmol/L/1HImmunological Including Allergic: Decrease in cellular immune responseTXAPA9 254,245,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 0.329 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, liver tumor Inhibitor Concentration (10 percent kill): 75.7 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TOLED5 205,146,2011
In Vitro/Human, liver tumor Inhibitor Concentration (20 percent kill): >100 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TOLED5 205,146,2011
In Vitro/kvxInhibitor Concentration Low: 200 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXCYAC 270,66,2010
In Vitro/kvxInhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 270,66,2010
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 5 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TOLED5 199,389,2010
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 13.33 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TOLED5 199,389,2010
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 5 mg/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 199,389,2010
In Vitro/Mouse, macrophage Inhibitor Concentration Low: 5 mg/L/24HIn Vitro Toxicity Studies: Other assaysTOLED5 199,389,2010
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration Low: 200 µmol/L/66HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TXCYAC 270,66,2010
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 0.12 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/paaInhibitor Concentration Low: 50 µmol/L/8HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 199,102,2010
In Vitro/paaInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 199,102,2010
In Vitro/pzxInhibitor Concentration Low: 30 µmol/L/2HIn Vitro Toxicity Studies: Other assaysTXCYAC 276,27,2010
In Vitro/pzxInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 204,108,2011
In Vitro/pzxInhibitor Concentration Low: 50 µmol/L/4HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TOLED5 204,108,2011
In Vitro/pzxInhibitor Concentration Low: 50 µmol/L/4HIn Vitro Toxicity Studies: Other assaysTOLED5 204,108,2011
In Vitro/pzxInhibitor Concentration Low: 50 µmol/L/4HIn Vitro Toxicity Studies: Apoptosis in vitroTOLED5 204,108,2011
In Vitro/pzxInhibitor Concentration Low: 50 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTOLED5 204,108,2011
inhalation/man lowest published toxic concentration: 4800 mg/m3/30MLung, Thorax, or Respiration: Other changesFerJJ# 10JAN1974
inhalation/rat Lowest published lethal concentration: 1960 mg/m3/10MEye: Other eye effects

Behavioral: Excitement
ARTODN 59,160,1986
inhalation/rat lethal concentration (50 percent kill): 2000 mg/m3HBTME* -,925,2007
intraperitoneal/guinea pig lowest published lethal dose: 173 mg/kgAEHLAU 11,201,1965
intraperitoneal/mouse lethal dose (50 percent kill): 24 mg/kgTXAPA9 63,461,1982
intraperitoneal/rat lethal dose (50 percent kill): 58 mg/kgEye: Miosis (pupilliary constriction)

Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VHTODE 30,224,1988
intraperitoneal/rat lowest published toxic dose: 9.3 mg/kgEndocrine: Hyperglycemia

Blood: Other changes
TXAPA9 32,316,1975
intraperitoneal/rat lowest published toxic dose: 5 mg/kgEye: Retinal changes pigmentary deposition, retinitis, other)

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 201,149,2004
intratracheal/rat Lethal dose: >1500 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ARDSBL 141(Suppl),A3-A937,1990
intravenous/mouse lethal dose (50 percent kill): 9090 µg/kgINJPD2 23,153,1991
intravenous/rabbit lowest published lethal dose: 11 mg/kgTXAPA9 9,269,1966
intravenous/rat lethal dose (50 percent kill): 3690 µg/kgINJPD2 23,153,1991
oral/child lowest published toxic dose: 169 mg/kgLung, Thorax, or Respiration: Dyspnea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Skin: After systemic exposure: Dermatitis, other
AEMED3 23,1383,1994
oral/guinea pig lethal dose (50 percent kill): 200 mg/kgFOREAE 7,313,1942
oral/mouse lowest published toxic dose: 2.04 mg/kgNutritional and Gross Metabolic: Changes in: Other metalsFCTOD7 39,571,2001
oral/mouse lowest published toxic dose: 1.56 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 66,34,2002
oral/mouse lethal dose (50 percent kill): 329 mg/kgINJPD2 23,153,1991
oral/rat lethal dose (50 percent kill): 350 mg/kgFOREAE 7,313,1942
subcutaneous/mouse lethal dose (50 percent kill): 330 mg/kgOYYAA2 8,1067,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 15 mg/kg/3D- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOSCF2 97,140,2007
oral/mammal (species unspecified) lowest published toxic dose: 6875 mg/kg/39W- intermittentCardiac: EKG changes not diagnostic of above

Vascular: BP elevation not characterized in autonomic section

Blood: Changes in erythrocyte (RBC) count
GISAAA 51(4),89,1986
oral/mouse lowest published toxic dose: 21504 mg/kg/12W- continuousReproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
EOGRAL 95,92,2001
oral/mouse lowest published toxic dose: 13440 mg/kg/12W- intermittentBehavioral: Fluid intake

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BPBLEO 23,305,2000
oral/mouse lowest published toxic dose: 76.44 mg/kg/14W- intermittentBlood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 72,75,2003
oral/mouse lowest published toxic dose: 109.2 mg/kg/20W- intermittentBehavioral: Euphoria

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 72,75,2003
oral/mouse lowest published toxic dose: 218.4 mg/kg/20W- intermittentBehavioral: Change in psychophysiological tests

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
TOXID9 72,75,2003
oral/mouse lowest published toxic dose: 49.42 gm/kg/3W- intermittentCardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: Ca
CBCPAI 132,53,2002
oral/rat lowest published toxic dose: 284.4 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
TOXID9 1,109,2001
oral/rat lowest published toxic dose: 284.4 mg/kg/13W- intermittentEndocrine: Changes in thymus weightTOXID9 1,109,2001
oral/rat lowest published toxic dose: 5690 mg/kg/13W- intermittentBrain and Coverings: Changes in brain weight

Related to Chronic Data: Changes in testicular weight
TOXID9 54,37,2000
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesGISAAA 44(10),17,1979
oral/rat lowest published toxic dose: 1680 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 48,334,1999
oral/rat lowest published toxic dose: 595 mg/kg/2W- continuousBehavioral: Fluid intakeFCTOD7 39,729,2001
oral/rat lowest published toxic dose: 3360 mg/kg/12W- continuousBehavioral: Fluid intakeFCTOD7 39,729,2001
oral/rat lowest published toxic dose: 900 mg/kg/30D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsTOLED5 187,137,2009
oral/rat lowest published toxic dose: 1.68 mg/kg/4W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainBJPCBM 158,442,2009
oral/rat lowest published toxic dose: 1.26 mg/kg/3W- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake
BJPCBM 158,442,2009
oral/rat lowest published toxic dose: 345.8 mg/kg/26W- continuousMusculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXCYAC 237,89,2007
subcutaneous/mouse lowest published toxic dose: 40881 µg/kg/3D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TXAPA9 242,182,2010
subcutaneous/mouse lowest published toxic dose: 40.5 mg/kg/3D- intermittentLiver: Other changesTOXID9 -,235,2009
subcutaneous/rat lowest published toxic dose: 40 mg/kg/2D- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 179,85,2002
unreported route/mouse lowest published toxic dose: 437.5 mg/kg/70D- intermittentLiver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 1,110,2001
unreported route/mouse lowest published toxic dose: 109.2 mg/kg/70D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOXID9 1,110,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (fume)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEWENTOX* -,479,2005
TOXICOLOGY REVIEWHBTME* ,925,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWMUTAEX 26,205,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,346,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg/m3 (fume)DTLVS* 3,283,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 mg/m3 (fume), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3 (fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Zn)/m3 (fume), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3 (fume), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 mg(Zn)/m3, resp, 2011
Occupational Exposure Limit-GERMANYMAK 2 mg(Zn)/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg(Zn)/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3; short term exposure limit 2 mg/m3, JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Zn)/m3, KZG-week 0.4 mg(Zn)/m3, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, smoke, resp, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg(Zn)/m3, KZG-week 4 mg(Zn)/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg/m3 (fume), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 1 mg/m3 (fume), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (fume), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg/m3, fumeCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3, fumeCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg/m3, fumeCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg/m3, fumeCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ZINC CHLORIDE FUME-air10H time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 77150; Number of Industries 172; Total Number of Facilities 22612; Number of Occupations 115; Total Number of Employees Exposed 353004; Total Number of Female Employees Exposed 87750
National Occupational Hazard Survey 1974Hazard Code 77150; Number of Industries 192; Total Number of Facilities 20416; Number of Occupations 84; Total Number of Employees Exposed 185570

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-125G
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