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Registry of Toxic Effects of Chemical Substances (RTECS)

Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl-

RTECS #

YS8925000

CAS #

330-54-1; 102962-29-8

Updated

April 2017

Molecular Weight

233.11

Molecular Formula

C9H10Cl2N2O

Synonyms

1-(3,4-Dichlorophenyl)-3,3-dimethyluree (French)
1,1-Dimethyl-3-(3,4-dichlorophenyl)urea
3-(3,4-Dichloor-fenyl)-1,1-dimethylureum (Dutch)
3-(3,4-Dichlorophenol)-1,1-dimethylurea
3-(3,4-Dichlorophenyl)-1,1-dimethylurea
3-(3,4-Dichlor-phenyl)-1,1-dimethyl-harnstoff (German)
3-(3,4-Dicloro-fenyl)-1,1-dimetil-urea (Italian)
AF 101
DCMU
Dichlorfenidim
Direx 4L
Diuron
Diuron (ACGIH)
Diuron 4L
DMU
DP Hardener 95
Duran
Farmco diuron
Herbatox
HW 920
Karmex
Karmex Diuron Herbicide
Karmex DW
Lucenit
Marmer
N'-(3,4-Dichlorophenyl)-N,N-dimethylurea
Sup'r flo
Telvar diuron weed killer
Unidron
USAF P-7
USAF XR-42

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisliver/hamster0.45 mg/L/20HMUREAV 721,89,2011
Cytogenetic Analysisovary/hamster45 mg/L/20HMUREAV 721,89,2011
DNA inhibitionoral/mouse1 gm/kgMUREAV 58,353,1978
micronucleus testintraperitoneal/mouse170 mg/kgHBPTO* 2,1523,2001
mutation in microorganisms/Salmonella typhimurium3 µg/plate (-enzymatic activation step)MUREAV 58,353,1978
sister chromatid exchangeliver/hamster45 mg/LMUREAV 721,89,2011

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 360 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GISAAA 49(8),83,1984
oral/rat 1250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemBECTA6 22,522,1979
oral/rat 3750 mg/kg (30D male)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 23,106,2007
oral/rat 3750 mg/kg (30D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)REPTED 23,106,2007
subcutaneous/mouse 1935 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Eye, ear
NTIS** PB223-160
unreported route/mammal (species unspecified) 144 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FEREAC 64,41302,1999

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 153 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgNTIS** AD277-689
oral/rat lethal dose (50 percent kill): 1017 mg/kgBehavioral: General anesthetic

Behavioral: Ataxia
JAFCAU 18,1104,1970
oral/rat lethal dose (50 percent kill): 1 gm/kgHBPTO* 2,1522,2001
skin/rat lethal dose (50 percent kill): >5 gm/kgFMCHA2 -,C115,1991
Tank with water/Shrimp lethal concentration (50 percent kill): 8800 µg/L/96HEESADV 73,360,2010
unreported route/duck lethal dose (50 percent kill): >2 gm/kgFMCHA2 -,C115,1991
unreported route/rat lethal dose (50 percent kill): 3400 mg/kg30ZDA9 -,231,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 90 mg/m3/4H/60D- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in spleen

Endocrine: Changes in thyroid weight
GISAAA 34(6),27,1969
oral/rat lowest published toxic dose: 10 gm/kg/10D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1522,2001
oral/rat lowest published toxic dose: 9 gm/kg/30D- continuousBlood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1522,2001
oral/rat lowest published toxic dose: 18 gm/kg/30D- continuousEndocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1522,2001
oral/rat lowest published toxic dose: 3375 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1522,2001
oral/rat lowest published toxic dose: 16.88 gm/kg/90D- continuousBlood: Normocytic anemia

Blood: Changes in bone marrow not included in above
HBPTO* 2,1522,2001
oral/rat lowest published toxic dose: 7987.5 mg/kg/426D- continuousEndocrine: Changes in spleen weight

Blood: Normocytic anemia

Blood: Changes in cell count (unspecified)
HBPTO* 2,1523,2001
oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1523,2001
oral/rat lowest published toxic dose: 682.5 mg/kg/13W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)HBPTO* 2,1523,2001
oral/rat lowest published toxic dose: 21000 mg/kg/20W- continuousKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 224,66,2006
oral/rat lowest published toxic dose: 4200 mg/kg/20W- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 224,66,2006
oral/rat lowest published toxic dose: 3750 mg/kg/30D- intermittentLiver: Changes in liver weightREPTED 23,106,2007
oral/rat lowest published toxic dose: 3416 mg/kg/20W- continuousKidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
TXCYAC 312,1,2013
oral/rat lowest published toxic dose: 8414 mg/kg/20W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Blood: Changes in spleen
TXCYAC 312,1,2013
oral/rat lowest published toxic dose: 14224 mg/kg/20W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 312,1,2013
oral/rat lowest published toxic dose: 1422.4 mg/kg/2W- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake
TXCYAC 312,1,2013
oral/rat lowest published toxic dose: 1433.04 mg/kg/7D- continuousTXCYAC 333,100,2015
oral/rat : 84.56 mg/kg/7D- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 325,21,2014
oral/rat : 332.92 mg/kg/7D- continuousKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladderTXCYAC 325,21,2014
oral/rat : 1331.4 mg/kg/7D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
TXCYAC 325,21,2014
oral/rat lowest published toxic dose: 61250 mg/kg/35W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
IJEBA6 37,503,1999
oral/rat lowest published toxic dose: 52500 µg/kg/30D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 36,76,1990
oral/rat lowest published toxic dose: 13620 mg/kg/61W- continuousBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
FCTOD7 31,285,1993

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,89,2005
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWFEREAC 72,32533,2007
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,115,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIURON-air10H time-weighted average 10 mg/m3NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code M0785; Number of Industries 8; Total Number of Facilities 75; Number of Occupations 12; Total Number of Employees Exposed 4216; Total Number of Female Employees Exposed 264
National Occupational Hazard Survey 1974Hazard Code M0785; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 374

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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