Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl-
RTECS #
YS8925000
CAS #
Updated
December 2017
Molecular Weight
233.11
Molecular Formula
C9H10Cl2N2O
Synonyms
1-(3,4-Dichlorophenyl)-3,3-dimethyluree (French)
1,1-Dimethyl-3-(3,4-dichlorophenyl)urea
3-(3,4-Dichloor-fenyl)-1,1-dimethylureum (Dutch)
3-(3,4-Dichlorophenol)-1,1-dimethylurea
3-(3,4-Dichlorophenyl)-1,1-dimethylurea
3-(3,4-Dichlor-phenyl)-1,1-dimethyl-harnstoff (German)
3-(3,4-Dicloro-fenyl)-1,1-dimetil-urea (Italian)
AF 101
DCMU
Dichlorfenidim
Direx 4L
Diuron
Diuron (ACGIH)
Diuron 4L
DMU
DP Hardener 95
Duran
Farmco diuron
Herbatox
HW 920
Karmex
Karmex Diuron Herbicide
Karmex DW
Lucenit
Marmer
N'-(3,4-Dichlorophenyl)-N,N-dimethylurea
Sup'r flo
Telvar diuron weed killer
Unidron
USAF P-7
USAF XR-42
1,1-Dimethyl-3-(3,4-dichlorophenyl)urea
3-(3,4-Dichloor-fenyl)-1,1-dimethylureum (Dutch)
3-(3,4-Dichlorophenol)-1,1-dimethylurea
3-(3,4-Dichlorophenyl)-1,1-dimethylurea
3-(3,4-Dichlor-phenyl)-1,1-dimethyl-harnstoff (German)
3-(3,4-Dicloro-fenyl)-1,1-dimetil-urea (Italian)
AF 101
DCMU
Dichlorfenidim
Direx 4L
Diuron
Diuron (ACGIH)
Diuron 4L
DMU
DP Hardener 95
Duran
Farmco diuron
Herbatox
HW 920
Karmex
Karmex Diuron Herbicide
Karmex DW
Lucenit
Marmer
N'-(3,4-Dichlorophenyl)-N,N-dimethylurea
Sup'r flo
Telvar diuron weed killer
Unidron
USAF P-7
USAF XR-42
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | liver/hamster | 0.45 mg/L/20H | MUREAV 721,89,2011 |
| Cytogenetic Analysis | ovary/hamster | 45 mg/L/20H | MUREAV 721,89,2011 |
| DNA inhibition | oral/mouse | 1 gm/kg | MUREAV 58,353,1978 |
| micronucleus test | intraperitoneal/mouse | 170 mg/kg | HBPTO* 2,1523,2001 |
| mutation in microorganisms | /Salmonella typhimurium | 3 µg/plate (-enzymatic activation step) | MUREAV 58,353,1978 |
| sister chromatid exchange | liver/hamster | 45 mg/L | MUREAV 721,89,2011 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 360 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | GISAAA 49(8),83,1984 |
| oral/rat | 1250 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | BECTA6 22,522,1979 |
| oral/rat | 3750 mg/kg (30D male) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | REPTED 23,106,2007 |
| oral/rat | 3750 mg/kg (30D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | REPTED 23,106,2007 |
| subcutaneous/mouse | 1935 mg/kg (6-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Eye, ear | NTIS** PB223-160 |
| unreported route/mammal (species unspecified) | 144 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FEREAC 64,41302,1999 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 153 gm/kg/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors | NTIS** PB223-159 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 200 µmol/L/24H | In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,1577,2015 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 200 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 29,1577,2015 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 50 µmol/L/72H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 29,1577,2015 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 200 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TIVIEQ 29,1577,2015 |
| In Vitro/jrd | Inhibitor Concentration Low: 200 µmol/L/48H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 29,1577,2015 |
| In Vitro/jrd | Inhibitor Concentration Low: 200 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,1577,2015 |
| In Vitro/jrd | Inhibitor Concentration Low: 100 µmol/L/48H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,1577,2015 |
| In Vitro/jrd | Inhibitor Concentration Low: 10 µmol/L/72H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,1577,2015 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 500 mg/kg | NTIS** AD277-689 | |
| oral/rat | lethal dose (50 percent kill): 1017 mg/kg | Behavioral: General anesthetic Behavioral: Ataxia | JAFCAU 18,1104,1970 |
| oral/rat | lethal dose (50 percent kill): 1 gm/kg | HBPTO* 2,1522,2001 | |
| skin/rat | lethal dose (50 percent kill): >5 gm/kg | FMCHA2 -,C115,1991 | |
| Tank with water/Shrimp | lethal concentration (50 percent kill): 8800 µg/L/96H | EESADV 73,360,2010 | |
| unreported route/duck | lethal dose (50 percent kill): >2 gm/kg | FMCHA2 -,C115,1991 | |
| unreported route/rat | lethal dose (50 percent kill): 3400 mg/kg | 30ZDA9 -,231,1971 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 90 mg/m3/4H/60D- intermittent | Kidney, Ureter, and Bladder: Proteinuria Blood: Changes in spleen Endocrine: Changes in thyroid weight | GISAAA 34(6),27,1969 |
| oral/rat | lowest published toxic dose: 10 gm/kg/10D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1522,2001 |
| oral/rat | lowest published toxic dose: 9 gm/kg/30D- continuous | Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1522,2001 |
| oral/rat | lowest published toxic dose: 18 gm/kg/30D- continuous | Endocrine: Changes in spleen weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HBPTO* 2,1522,2001 |
| oral/rat | lowest published toxic dose: 3375 mg/kg/90D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1522,2001 |
| oral/rat | lowest published toxic dose: 16.88 gm/kg/90D- continuous | Blood: Normocytic anemia Blood: Changes in bone marrow not included in above | HBPTO* 2,1522,2001 |
| oral/rat | lowest published toxic dose: 7987.5 mg/kg/426D- continuous | Endocrine: Changes in spleen weight Blood: Normocytic anemia Blood: Changes in cell count (unspecified) | HBPTO* 2,1523,2001 |
| oral/rat | lowest published toxic dose: 5000 mg/kg/10D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1523,2001 |
| oral/rat | lowest published toxic dose: 682.5 mg/kg/13W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | HBPTO* 2,1523,2001 |
| oral/rat | lowest published toxic dose: 21000 mg/kg/20W- continuous | Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 224,66,2006 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/20W- continuous | Kidney, Ureter, and Bladder: Other changes | TXCYAC 224,66,2006 |
| oral/rat | lowest published toxic dose: 3750 mg/kg/30D- intermittent | Liver: Changes in liver weight | REPTED 23,106,2007 |
| oral/rat | lowest published toxic dose: 3416 mg/kg/20W- continuous | Kidney, Ureter, and Bladder: Bladder tumors Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder | TXCYAC 312,1,2013 |
| oral/rat | lowest published toxic dose: 8414 mg/kg/20W- continuous | Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight Blood: Changes in spleen | TXCYAC 312,1,2013 |
| oral/rat | lowest published toxic dose: 14224 mg/kg/20W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 312,1,2013 |
| oral/rat | lowest published toxic dose: 1422.4 mg/kg/2W- continuous | Behavioral: Food intake (animal) Behavioral: Fluid intake | TXCYAC 312,1,2013 |
| oral/rat | lowest published toxic dose: 1433.04 mg/kg/7D- continuous | TXCYAC 333,100,2015 | |
| oral/rat | lowest published toxic dose: 84.56 mg/kg/7D- continuous | Kidney, Ureter, and Bladder: Other changes | TXCYAC 325,21,2014 |
| oral/rat | lowest published toxic dose: 332.92 mg/kg/7D- continuous | Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder | TXCYAC 325,21,2014 |
| oral/rat | lowest published toxic dose: 1331.4 mg/kg/7D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Behavioral: Food intake (animal) | TXCYAC 325,21,2014 |
| oral/rat | lowest published toxic dose: 61250 mg/kg/35W- continuous | Liver: Hepatitis (hepatocellular necrosis), diffuse Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | IJEBA6 37,503,1999 |
| oral/rat | lowest published toxic dose: 52500 µg/kg/30D- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TXAPA9 36,76,1990 |
| oral/rat | lowest published toxic dose: 13620 mg/kg/61W- continuous | Blood: Methemoglobinemia- Carboxhemoglobinemia Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count | FCTOD7 31,285,1993 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 mg/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,89,2005 | |
| TOXICOLOGY REVIEW | FEREAC 73,31788,2008 | |
| TOXICOLOGY REVIEW | FEREAC 72,32533,2007 | |
| TOXICOLOGY REVIEW | HUTOX* -,551,1996 | |
| TOXICOLOGY REVIEW | FEREAC 73,54954,2008 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,115,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, carc 3, inhal, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 mg/m3, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIURON-air | 10H time-weighted average 10 mg/m3 | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code M0785; Number of Industries 8; Total Number of Facilities 75; Number of Occupations 12; Total Number of Employees Exposed 4216; Total Number of Female Employees Exposed 264 | |
| National Occupational Hazard Survey 1974 | Hazard Code M0785; Number of Industries 2; Total Number of Facilities 120; Number of Occupations 2; Total Number of Employees Exposed 374 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health