s-Triazole, 3-amino-

RTECS #
XZ3850000
CAS #
61-82-5; 155-25-9
See: NMAM or OSHA Methods
Updated
March 2018
Molecular Weight
84.10
Molecular Formula
C2H4N4
Synonyms
1H-1,2,4-Triazol-3-amine
3,A-T
3-Amino-1,2,4-triazole
3-Amino-1,2,4-triazole (ACGIH)
3-Amino-1H-1,2,4-triazole
3-Amino-s-triazole
3-Aminotriazole
Amino triazole weedkiller 90
Aminotriazole (plant regulator)
Aminotriazol-spritzpulver
Amitol
Amitrol
Amitrol 90
Amitrole
Amitrole (ACGIH)
Amitrol-T
Amizol
AT
ATA
Campaprim A 1544
Cytrol
Cytrole
Diurol
Diurol 5030
Elmasil
Emisol
Emisol 50
Emisol F
ENT 25445
Herbidal total
Herbizole
Kleer-lot
Orga-414
Radoxone TL
Ramizol
RCRA waste number U011
Simazol
Solution concentree T271
Triazolamine
USAF XR-22
Vorox
Vorox AA
Vorox AS
Weedar ADS
Weedar AT
Weedazin
Weedazin arginit
Weedazol
Weedex granulat
X-All liquid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA Damage/Bacillus subtilis1 mg/discPMRSDJ 1,175,1981
DNA Damageliver/human0.1 mmol/l/48HMUREAV 696,21,2010
DNA inhibitionfibroblast/human100 mmol/LMUREAV 183,89,1987
DNA repair/Saccharomyes cerevisiae100 mg/LPMRSDJ 1,502,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae300 mg/LPMRSDJ 1,491,1981
gene conversion and mitotic recombination/Aspergillus nidulans600 µg/LMUREAV 147,288,1985
host-mediated assaySalmonella typhimurium/mouse12 mg/kgJJIND8 62,911,1979
morphological transformembryo/hamster10 mg/LTOLED5 7,211,1981
morphological transformkidney/hamster250 mg/LPMRSDJ 1,638,1981
morphological transformembryo/rat80 mg/LJJIND8 67,1303,1981
morphological transformembryo/mouse125 mg/LEMMUEG 12,21,1988
morphological transformfibroblast/mouse0.01 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
mutation in mammalian somatic cellsembryo/hamster1 mg/LMUREAV 140,205,1984
mutation in microorganisms/Other microorganisms1 mg/plate (-enzymatic activation step)MUREAV 57,277,1978
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)PMRSDJ 1,351,1981
mutation in microorganisms/Escherichia coli50 µg/plate (+enzymatic activation step)PMRSDJ 1,351,1981
mutation in microorganisms/Saccharomyes cerevisiae840 mg/L/16HMUTAEX 20,105,2004
phage inhibition capacity/Escherichia coli15 gm/LVIRLAX 99,257,1979
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,468,1981
sex chromosome loss and nondisjunction/Aspergillus nidulans600 µg/LMUREAV 147,288,1985
specific locus testoral/Drosophila melanogaster500 µmol/LMUREAV 242,169,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 700 µg/kg (22D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemANREAK 145,284,1963
oral/mouse 2600 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)ARTODN 33,41,1974
oral/mouse 1935 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160
subcutaneous/mouse 4176 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 113 gm/kg/3W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 42,1101,1969
oral/mouse toxic dose: 366 gm/kg/26W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
TOLED5 29,145,1985
oral/mouse lowest published toxic dose: 21.6 gm/kg/180D- intermittentTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CRNGDP 30,1614,2009
oral/rat lowest published toxic dose: 4595 mg/kg/2.5Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
TXAPA9 69,161,1983
oral/rat toxic dose: 3670 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
SCIEAS 132,296,1960
oral/rat toxic dose: 122 gm/kg/70W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
JNCIAM 57,861,1976
oral/rat toxic dose: 105 gm/kg/60W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
NMJOAA 23,83,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNTIS** AD277-689
intravenous/mouse lethal dose (50 percent kill): >5 gm/kgOYYAA2 13,597,1977
oral/mouse lethal dose (50 percent kill): 14700 mg/kgPCOC** -,33,1966
oral/quail lethal dose (50 percent kill): >316 mg/kgEESADV 6,149,1982
oral/rat lethal dose (50 percent kill): 1100 mg/kgRREVAH 10,97,1965
skin/rat lethal dose (50 percent kill): >10 gm/kgWRPCA2 9,119,1970
Tank with water/Zebrafish the toxic concentration that affects 50% of the population of interest): 2080.2 µmol/L/3DEndocrine: Evidence of thyroid hypofunctionTXAPA9 269,169,2013
Tank with water/Zebrafish the toxic concentration that affects 10% of the population of interest): 561.9 µmol/L/3DEndocrine: Evidence of thyroid hypofunctionTXAPA9 269,169,2013

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/hamster lowest published toxic dose: 4704 mg/kg/28W- continuousEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ARTODN 60,343,1987
oral/mouse lowest published toxic dose: 14070 mg/kg/3W- continuousBlood: Changes in other cell count (unspecified)NSAPCC 375(Suppl 1),30,2007
oral/rat lowest published toxic dose: 700 mg/kg/28D- intermittentEndocrine: Changes in thyroid weightARTODN 83,459,2009
oral/rat lowest published toxic dose: 3500 mg/kg/28D- intermittentEndocrine: Evidence of thyroid hypofunction

Endocrine: Changes in pituitary weight

Endocrine: Changes in thyroid weight
ARTODN 83,459,2009
oral/rat lowest published toxic dose: 313 mg/kg/90D- continuousEndocrine: Thyroid weight (goiter)JEPTDQ 1(1),147,1977
oral/rat lowest published toxic dose: 300 mg/kg/3D- continuousEndocrine: Other changesJOENAK 94,131,1982
oral/rat lowest published toxic dose: 700 mg/kg/7D- continuousEndocrine: Thyroid weight (goiter)JOENAK 94,131,1982
oral/rat lowest published toxic dose: 26250 mg/kg/30W- continuousEndocrine: Thyroid weight (goiter)JJIND8 57,861,1976
oral/rat lowest published toxic dose: 61250 mg/kg/70W- continuousEndocrine: TumorsJJIND8 57,861,1976
oral/rat lowest published toxic dose: 420 mg/kg/14D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 60,45,1981
oral/rat lowest published toxic dose: 168 mg/kg/4W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJTSCDR 30,1,2005
oral/rat lowest published toxic dose: 252 mg/kg/6W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight
JTSCDR 30,1,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 7,31,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 7,31,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 79,-,2000
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWMUREAV 653,23,2008
TOXICOLOGY REVIEWREPTED 25,304,2007
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWIMEMDT 79,381,
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWREPTED 33,188,2012
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUREAV 786-788,14,2015
TOXICOLOGY REVIEWMUREAV 795,7,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,85,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, short term exposure limit 3 ppm, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.06 ppm (0.2 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.2 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.2 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO AMITROLE-air8H Carcinogen time-weighted average 0.2 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84718; Number of Industries 3; Total Number of Facilities 8; Number of Occupations 4; Total Number of Employees Exposed 693; Total Number of Female Employees Exposed 24

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
Page last reviewed: November 16, 2018