as-Triazin-5(4H)-one, 4-amino-6-tert-butyl-3-(methylthio)-

RTECS #

XZ2990000

CAS #

21087-64-9
See: NMAM or OSHA Methods

Updated

December 2016

Molecular Weight

214.32

Molecular Formula

C₈H₁₄N₄OS

Synonyms

1,2,4-Triazin-5(4H)-one, 4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-
1,2,4-Triazin-5-one, 4-amino-6-tert-butyl-3-(methylthio)-
4-Amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one
4-Amino-6-tert-butyl-3-(methylthio)-1,2,4-triazin-5-one
4-Amino-6-tert-butyl-3-methylthio-as-triazin-5-one
BAY 61597
BAY dic 1468
Bayer 6159H
Bayer 6443H
Bayer 94337
DIC 1468
Lexone
Lexone 4L
Lexone DF
Metribuzin
Metribuzin (ACGIH)
NTN 70
Sencor
Sencor 4
Sencor DF
Sencoral
Sencorer
Sencorex
Zenkor

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1 gm/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)	NNGADV 12,127,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	Lethal concentration: >860 mg/m³/4H		85INA8 6,1042,1991
inhalation/rat	lethal concentration (50 percent kill): >860 mg/m³/4H		NNGADV 12,127,1987
intraperitoneal/mouse	lethal dose (50 percent kill): 210 mg/kg	Behavioral: Somnolence (general depressed activity)	PCBPBS 23,123,1984
intraperitoneal/rat	lethal dose (50 percent kill): 239 mg/kg		NNGADV 12,127,1987
oral/cat	lethal dose (50 percent kill): >500 mg/kg		85JFAN A280,1983
oral/guinea pig	lethal dose (50 percent kill): 250 mg/kg		85DPAN -,-,1971/1976
oral/mouse	lethal dose (50 percent kill): 564 mg/kg		NNGADV 12,127,1987
oral/quail	lethal dose (50 percent kill): 164 mg/kg		PEMNDP 8,573,1987
oral/rat	lethal dose (50 percent kill): 1100 mg/kg		FMCHA2 -,C204,1991
skin/mouse	lethal dose (50 percent kill): >1 gm/kg		NNGADV 12,127,1987
skin/rabbit	lethal dose (50 percent kill): >20 gm/kg		FMCHA2 -,C204,1991
skin/rat	lethal dose (50 percent kill): 2 gm/kg		85JCAE -,1001,1986
subcutaneous/mouse	lethal dose (50 percent kill): 367 mg/kg		NNGADV 12,127,1987
subcutaneous/rat	lethal dose (50 percent kill): 814 mg/kg		NNGADV 12,127,1987
unreported route/quail	lethal dose (50 percent kill): 168 mg/kg		FMCHA2 -,C204,1991

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 27375 mg/kg/2Y- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NNGADV 12,127,1987
oral/Dog	lowest published toxic dose: 27.3 gm/kg/104W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1512,2001
oral/mouse	lowest published toxic dose: 65.7 gm/kg/78W- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in spleen weight Blood: Other changes	HBPTO* 2,1514,2001
oral/rat	lowest published toxic dose: 10.95 gm/kg/2Y- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1514,2001
oral/rat	lowest published toxic dose: 10.95 gm/kg/2Y- continuous	Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)	HBPTO* 2,1514,2001
oral/rat	lowest published toxic dose: 10.92 gm/kg/104W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 2,1512,2001
oral/rat	lowest published toxic dose: 64800 µg/kg/15W- continuous	Brain and Coverings: Other degenerative changes	JTEHD6 30,209,1990
oral/rat	lowest published toxic dose: 4550 mg/kg/26W- intermittent	Immunological Including Allergic: Increased immune response	GISAAA 52(11),76,1987
oral/rat	lowest published toxic dose: 13140 mg/kg/2Y- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NNGADV 12,127,1987

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		FEREAC 71,43906,2006
TOXICOLOGY REVIEW		FEREAC 72,39318,2007
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		TXAPA9 268,157,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,133,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 10 mg/m³, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METRIBUZIN-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health