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Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine, hexahydro-1,3,5-trinitro-

RTECS #

XY9450000

CAS #

121-82-4

Updated

December 2016

Molecular Weight

222.15

Molecular Formula

C3H6N6O6

Synonyms

1,3,5-Triazine, hexahydro-1,3,5-trinitro- (9CI)
1,3,5-Trinitro-1,3,5-triazacyclohexane
1,3,5-Trinitrohexahydro-s-triazine
CX 84A
Cyclonite
Cyclonite (ACGIH:OSHA)
Cyclotrimethylenenitramine
Cyclotrimethylenetrinitramine
Cyklonit (Czech)
Esaidro-1,3,5-trinitro-1,3,5-triazina (Italian)
Heksogen (Polish)
Hexahydro-1,3,5-trinitro-1,3,5-triazin (German)
Hexahydro-1,3,5-trinitro-1,3,5-triazine
Hexahydro-1,3,5-trinitro-s-triazine
Hexogeen (Dutch)
Hexogen
Hexogen (Explosive)
Hexogen 5W
Hexolite
KHP 281
Pbx(AF) 108
PBXW 108(E)
PE 4
RDX
RDX (OSHA)
sym-Trimethylenetrinitramine
Trimethyleentrinitramine (Dutch)
Trimethylenetrinitramine
Trinitrocyclotrimethylene triamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium88.9 µg/plate/73H (+enzymatic activation step)MUREAV 629,64,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10 gm/kg (13W male/13W pre-22D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** AD-A092-531
oral/rat 3 gm/kg (13W male/13W pre-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** AD-A092-531
oral/rat 20 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** AD-A166-249

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): 12.3 µmol/L/10MIn Vitro Toxicity Studies: Other assaysNRTXDN 40,75,2014
intraperitoneal/rat lowest published lethal dose: 10 mg/kgEATR** EB-TR-73040
intravenous/guinea pig lethal dose (50 percent kill): 25 mg/kgEATR** EB-TR-73040
intravenous/mouse lethal dose (50 percent kill): 19 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
EATR** EB-TR-73040
intravenous/rat lowest published lethal dose: 18 mg/kgEATR** EB-TR-73040
oral/cat lowest published lethal dose: 100 mg/kgFATOAO 7,43,1944
oral/child lowest published toxic dose: 85 mg/kgBehavioral: Convulsions or effect on seizure thresholdJTCTDW 24,305,1986
oral/mouse lethal dose (50 percent kill): 59 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** AD-A092-531
oral/pig lowest published toxic dose: 43 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
TOXID9 44,254,2005
oral/pig lowest published toxic dose: 43 mg/kgGastrointestinal: Nausea or vomitingTOXID9 44,254,2005
oral/quail lowest published lethal dose: 187 mg/kgTOXID9 60,230,2001
oral/rabbit lowest published lethal dose: 500 mg/kgFATOAO 7,43,1944
oral/rat lowest published toxic dose: 94 mg/kgBlood: Changes in erythrocyte (RBC) countTXAPA9 266,443,2013
oral/rat lowest published toxic dose: 12 mg/kgBlood: Changes in bone marrow not included in aboveTXAPA9 266,443,2013
oral/rat lowest published toxic dose: 68 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOXID9 -,109,2009
oral/rat lowest published toxic dose: 18 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 22,620,2009
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXAPA9 39,531,1977
Tank with water/Lobster Lowest published lethal concentration: 9.9 mg/L/10DEESADV 73,1653,2010
Tank with water/Minnow Lowest published lethal concentration: 10 mg/L/10DNutritional and Gross Metabolic: Weight loss or decreased weight gainTIVIEQ 101,135,2011

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1800 mg/kg/6W- intermittentBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 31,21,1949
oral/mouse lowest published toxic dose: 28800 mg/kg/90D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD-A092-531
oral/rat lowest published toxic dose: 3600 mg/kg/90D- continuousCardiac: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTIS** AD-A092-531
oral/rat lowest published toxic dose: 720 mg/kg/90D- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 90,332,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCTOXAO 45,454,2007
TOXICOLOGY REVIEWMUREAV 714,105,2011
TOXICOLOGY REVIEWMUREAV 717,67,2011
TOXICOLOGY REVIEWNRTXDN 33,530,2012
TOXICOLOGY REVIEWTOLED5 198,100,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1.5 mg/m3 (skin)DTLVS* 3,221,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1.5 mg/m3;KZW 3 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1.5 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1.5 mg/m3, short term exposure limit 4.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1.5 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1.5 mg/m3, JAN1999
Occupational Exposure Limit-PERU0.5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1.5 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.4 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLONITE-air10H time-weighted average 1.5 mg/m3;short term exposure limit 3 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code M0317; Number of Industries 3; Total Number of Facilities 36; Number of Occupations 4; Total Number of Employees Exposed 488
National Occupational Hazard Survey 1974Hazard Code M0317; Number of Industries 1; Total Number of Facilities 20; Number of Occupations 2; Total Number of Employees Exposed 242

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264255)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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