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Registry of Toxic Effects of Chemical Substances (RTECS)

Toxaphene

RTECS #

XW5250000

CAS #

8001-35-2; 8022-04-6

Updated

December 2016

Molecular Weight

413.80

Molecular Formula

C10H10Cl8

Synonyms

Agricide maggot killer (F)
Alltox
Anatox
Attac 4-2
Attac 4-4
Attac 6
Attac 6-3
Attac 8
Camphechlor
Camphochlor
Camphoclor
Camphofene huileux
Chlorinated camphene
Chlorinated camphene (OSHA)
Chlorinated camphene 60% (ACGIH)
Chlorinated camphene, technical
Clor Chem T-590
Compound 3956
Cristoxo 90
ENT 9,735
Estonox
Fasco-terpene
Geniphene
Hercules 3956
Kamfochlor
Latka 3956 (Czech)
M 5055
Melipax
NCI-C00259
PCC
Phenacide
Phenatox
Polychlorocamphene
RCRA waste number P123
Strobane T-90
Strobane-T
Toxafeen (Dutch)
Toxakil
Toxaphen (German)
Toxaphene (OSHA)
Toxaphene fume
Toxon 63
Toxyphen
Vertac toxaphene 90

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /mammal (species unspecified) 500 mg moderateJAMAAP 149,1135,1952

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysismultiple/other fish1500 µg/kg/10D-continuousBIZNAT 94,441,1975
micronucleus testliver/human20 µmol/L/24HTXCYAC 198,315,2004
morphological transformembryo/mouse12400 µg/LPMRSDJ 5,659,1985
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)SCIEAS 205,591,1979
phage inhibition capacity/Escherichia coli100 µmol/LMUREAV 182,193,1987
phage inhibition capacity/Escherichia coli0.381 mmol/L (+enzymatic activation step)EMMUEG 36,206,2000
sister chromatid exchangelung/hamster5 mg/LMUREAV 230,29,1990
sister chromatid exchangelymphocyte/human10 µmol/LARTODN 52,221,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 280 mg/kg (10W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GISAAA 45(5),14,1980
oral/rat 900 µg/kg (5-22D pregnant)Reproductive: Effects on newborn: BehavioralAECTCV 9,247,1980
oral/rat 150 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemBECTA6 15,660,1976
oral/rat 250 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)BECTA6 15,660,1976
oral/mouse 375 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JTEHD6 10,541,1982
oral/mouse 100 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTCMUD8 5,3,1985
oral/mouse 375 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TCMUD8 4,403,1984
oral/rat 88 mg/kg (22D pregnant)Reproductive: Other developmental abnormalitiesVCVPS* -,304,1998
oral/hamster 64 mg/kg (16D pregnant)Reproductive: Other developmental abnormalitiesVCVPS* -,304,1998
oral/rat 280 mg/kg (10W prior to copulation)Reproductive: Other developmental abnormalitiesVCVPS* -,304,1998
oral/hamster 280 mg/kg (10W prior to copulation)Reproductive: Other developmental abnormalitiesVCVPS* -,304,1998

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 6600 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-37,1979
oral/mouse toxic dose: 13 gm/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-37,1979
oral/rat lowest published toxic dose: 30 gm/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-37,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 2000 mg/m3/2HJAMAAP 149,1135,1952
inhalation/mouse lethal concentration (50 percent kill): 2000 mg/m3/2HBehavioral: Tetany

Lung, Thorax, or Respiration: Respiratory obstruction

Nutritional and Gross Metabolic: Body temperature decrease
VCVPS* -,302,1998
intraperitoneal/mouse lethal dose (50 percent kill): 42 mg/kgJAFCAU 22,653,1974
intraperitoneal/rat lowest published lethal dose: 70 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
BECTA6 19,47,1978
intraperitoneal/rat lowest published toxic dose: 165.5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
oral/cat lowest published toxic dose: 70 mg/kgBehavioral: Tetany

Behavioral: Muscle contraction or spasticity
VCVPS* -,302,1998
oral/Dog lethal dose (50 percent kill): 15 mg/kgVCVGH* -,556,1990
oral/Dog lethal dose (50 percent kill): 15 mg/kgBehavioral: Tetany

Behavioral: Muscle contraction or spasticity
VCVPS* -,302,1998
oral/duck lethal dose (50 percent kill): 31 mg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Respiratory obstruction

Nutritional and Gross Metabolic: Body temperature decrease
VCVPS* -,302,1998
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgVCVGH* -,556,1990
oral/hamster lethal dose (50 percent kill): 200 mg/kgTXAPA9 48,A192,1979
oral/human lowest published lethal dose: 28 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma
34ZIAG -,598,1969
oral/human lowest published lethal dose: 60 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsVCVPS* -,303,1998
oral/man lowest published lethal dose: 29 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
CMEP** -,-,1956
oral/mouse lethal dose (50 percent kill): 45 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Respiratory obstruction

Nutritional and Gross Metabolic: Body temperature decrease
VCVPS* -,302,1998
oral/mouse lethal dose (50 percent kill): 45 mg/kgVCVGH* -,556,1990
oral/rabbit lethal dose (50 percent kill): 25 mg/kgVCVGH* -,556,1990
oral/rabbit lethal dose (50 percent kill): 25 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Respiratory obstruction

Nutritional and Gross Metabolic: Body temperature decrease
VCVPS* -,302,1998
oral/rat lethal dose (50 percent kill): 40 mg/kgBehavioral: Tetany

Lung, Thorax, or Respiration: Respiratory obstruction

Nutritional and Gross Metabolic: Body temperature decrease
VCVPS* -,302,1998
oral/rat lethal dose (50 percent kill): 40 mg/kgVCVGH* -,556,1990
oral/rat lowest published toxic dose: 300 mg/kgVCVPS* -,302,1998
oral/rat lowest published toxic dose: 300 mg/kgBehavioral: Tetany

Behavioral: Muscle contraction or spasticity
VCVPS* -,302,1998
parenteral/rat lethal dose (50 percent kill): 90 mg/kgDEVEAA 26,5,1972
skin/human lowest published toxic dose: 657 mg/kgSkin: After systemic exposure: Dermatitis, allergicCMEP** -,1,1956
skin/mouse lethal dose (50 percent kill): 250 mg/kgVCVGH* -,556,1990
skin/rabbit lethal dose (50 percent kill): 250 mg/kgVCVGH* -,556,1990
skin/rabbit lethal dose (50 percent kill): 1025 mg/kgBehavioral: Excitement

Behavioral: Food intake (animal)

Vascular: Regional or general arteriolar or venous dilation
JEENAI 46,702,1953
skin/rat lethal dose (50 percent kill): 250 mg/kgVCVGH* -,556,1990
skin/rat lethal dose (50 percent kill): 940 mg/kgBehavioral: Alteration of classical conditioning

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
VCVPS* -,303,1998
unreported route/man lowest published lethal dose: 44 mg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 45 mg/kgCYGEDX 8(1),23,1974
unreported route/rat lethal dose (50 percent kill): 240 mg/kgCYGEDX 8(1),23,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 20 mg/m3/3Y- intermittentCardiac: Arrythmias (indlucing changes in conduction)

Behavioral: Wakefulness

Behavioral: Headache
VCVPS* -,304,1998
intraperitoneal/rat lowest published toxic dose: 175 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
oral/Dog lowest published toxic dose: 385 mg/kg/13W- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 7,406,1986
oral/guinea pig lowest published toxic dose: 120 mg/kg/60D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEBIDP 13,315,1992
oral/hamster lowest published toxic dose: 280 mg/kg/10W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesVCVPS* -,304,1998
oral/hamster lowest published toxic dose: 64 mg/kg/16D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesVCVPS* -,304,1998
oral/monkey lowest published toxic dose: 95 mg/kg/34W- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 54,335,2000
oral/monkey lowest published toxic dose: 6.3 mg/kg/9W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)FCTOD7 39,467,2001
oral/monkey lowest published toxic dose: 392 mg/kg/70W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Nails
FCTOD7 39,467,2001
oral/monkey lowest published toxic dose: 148 mg/kg/53W- intermittentImmunological Including Allergic: Decrease in humoral immune responseFCTOD7 39,947,2001
oral/monkey lowest published toxic dose: 296 mg/kg/46W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
FCTOD7 39,947,2001
oral/monkey lowest published toxic dose: 268 mg/kg/34W- continuousImmunological Including Allergic: Decrease in humoral immune responseFCTOD7 39,1243,2001
oral/monkey lowest published toxic dose: 364 mg/kg/52W- continuousEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
FCTOD7 39,1243,2001
oral/monkey lowest published toxic dose: 364 mg/kg/52W- continuousLiver: Changes in liver weight

Endocrine: Effect on menstrual cycle

Endocrine: Changes in spleen weight
FCTOD7 39,1243,2001
oral/quail lowest published toxic dose: 126 mg/kg/18W- continuousEndocrine: Changes in adrenal weight

Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
POSCAL 53,125,1974
oral/rabbit lowest published toxic dose: 456.2 mg/kg/26W- intermittentMusculoskeletal: Other changesVCVPS* -,304,1998
oral/rat lowest published toxic dose: 280 mg/kg/10W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesVCVPS* -,304,1998
oral/rat lowest published toxic dose: 88 mg/kg/22D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesVCVPS* -,304,1998
oral/rat lowest published toxic dose: 157.5 mg/kg/7D- intermittentLiver: Other changesMUREAV 746,144,2012
oral/rat lowest published toxic dose: 1875 mg/kg/25D- intermittentEndocrine: Other changesRTOPDW 24,184,1996
oral/rat lowest published toxic dose: 4186 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 7,406,1986
oral/rat lowest published toxic dose: 328 mg/kg/39W- continuousLiver: Other changesAMPLAO 64,614,1957
oral/rat lowest published toxic dose: 120 mg/kg/4W- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Immunological Including Allergic: Decrease in cellular immune response
VCVPS* -,304,1998
unreported route/chicken lowest published toxic dose: 480 mg/kg/10D- intermittentBrain and Coverings: Changes in surface EEG

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
FIZHDO 27,557,1981
unreported route/mammal (species unspecified) lowest published toxic dose: 73 gm/kg/2Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVPS* -,304,1998

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3;short term exposure limit 1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 79,-,2000
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWENTOX* -,207,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWIMEMDT 79,569,
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWMUREAV 760,1,2014
TOXICOLOGY REVIEWMUREAV 764,31,2015
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,214,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,45,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3; short term exposure limit 1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 mg/m3; short term exposure limit 1 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (150 mg/m3);short term exposure limit 50 ppm (300 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, carc 2, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINATED CAMPHENE-airCarcinogen lowest feasible conc.NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 73500; Number of Industries 1; Total Number of Facilities 68; Number of Occupations 2; Total Number of Employees Exposed 203

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121057/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-37,1979
NCI Carcinogenesis Bioassay (feed);equivocal evidence:ratNCITR* NCI-TR-37,1979
NIOSH Analytical Method, 1994: Chlorinated camphene, 5039
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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