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Registry of Toxic Effects of Chemical Substances (RTECS)

Sucrose

RTECS #

WN6500000

CAS #

57-50-1

Updated

April 2017

Molecular Weight

342.34

Molecular Formula

C12H22O11

Synonyms

(alpha-D-Glucosido)-beta-D-fructofuranoside
alpha-D-Glucopyranosyl beta-D-fructofuranoside
Beet sugar
beta-D-Fructofuranoside, alpha-D-glucopyranosyl
CANE sugar
Confectioner's sugar
Fructofuranoside, alpha-D-glucopyranosyl, beta-D
Glucopyranoside, beta-D-fructofuranosyl, alpha-D
Granulated sugar
NCI-C56597
Rock candy
Saccharose
Saccharum
Sucrose (ACGIH:OSHA)
Sugar

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 gm/LATSUDG 4,41,1980
Cytogenetic Analysisovary/hamster275 mmol/LMUREAV 189,15,1987
DNA repair/Saccharomyes cerevisiae300 mg/LPMRSDJ 1,502,1981
mutation in microorganisms/Salmonella typhimurium600 µg/plate (-enzymatic activation step)PMRSDJ 1,343,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1548 gm/kg (21D prior to copulation/1-22D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemIJMDAI 16,789,1980
oral/rat 683 gm/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
AJCNAC 28,1416,1975
oral/rat 683 gm/kg (21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)AJCNAC 28,1416,1975
oral/mammal (species unspecified) 54810 mg/kg (15-35D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 30,203,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 200 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): >100 mg/L/48HIn Vitro Toxicity Studies: Cell protein synthesisJOETD7 155,1393,2014
In Vitro/Rat, glioma Inhibitor Concentration (50 percent kill): >100 mg/L/48HIn Vitro Toxicity Studies: Cell protein synthesisJOETD7 155,1393,2014
intraperitoneal/mouse lethal dose (50 percent kill): 14000 mg/kgPCJOAU 15,139,1981
oral/domestic animal lowest published lethal dose: 40 gm/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
NAREA4 30,503,1960
oral/human lowest published toxic dose: 0.096 µg/kgBehavioral: AnalgesiaAPHRER 39,1029,2005
oral/mouse lowest published toxic dose: 2 mg/kgEndocrine: HyperglycemiaJPHSC* 104,29,2007
oral/rat lethal dose (50 percent kill): 29700 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 7,609,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2730 gm/kg/2W- continuousCardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
LIFSAK 71,1303,2002
oral/rat lowest published toxic dose: 700000 mg/kg/35D- continuousGastrointestinal: Other changesFCTOD7 46,752,2008
oral/rat lowest published toxic dose: 1050 gm/kg/10W- intermittentEndocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JPHSC* 102,213,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 17,313,1993
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDNUISANCE PARTICULATESDTLWS* 3,28,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3, total dustCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3, respirable dustCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable dustCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81515; Number of Industries 108; Total Number of Facilities 15179; Number of Occupations 110; Total Number of Employees Exposed 368912; Total Number of Female Employees Exposed 169962
National Occupational Hazard Survey 1974Hazard Code 81515; Number of Industries 101; Total Number of Facilities 12044; Number of Occupations 86; Total Number of Employees Exposed 121005

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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