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Registry of Toxic Effects of Chemical Substances (RTECS)

Succinonitrile, tetramethyl-

RTECS #

WN4025000

CAS #

3333-52-6

Updated

September 2013

Molecular Weight

136.22

Molecular Formula

C8H12N2

Synonyms

2,2,3,3-Tetramethylbutanedinitrile
Butanedinitrile, tetramethyl- (9CI)
CP 75475
Tetramethyl succinonitrile
Tetramethyl succinonitrile (ACGIH:OSHA)
Tetramethylbutanedinitrile
Tetramethylsuccinic acid dinitrile
Tetramethylsuccinodinitrile
Tetramethylsuccinonitrile
Tetramethylsukcinonitril (Czech)
TMSN

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster 9944 µg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 3,41,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lethal concentration: >281 mg/m3/2HATXKA8 16,367,1957
inhalation/mouse Lowest published lethal concentration: 125 mg/m3/2HBehavioral: Convulsions or effect on seizure thresholdATXKA8 16,367,1957
inhalation/rat Lowest published lethal concentration: 60 ppm/2HFEPRA7 8,205,1949
intraperitoneal/mouse lethal dose (50 percent kill): 17710 µg/kgBehavioral: Convulsions or effect on seizure thresholdJPETAB 223,635,1982
intraperitoneal/rat lethal dose (50 percent kill): 17500 µg/kgATXKA8 16,367,1957
intravenous/mouse lethal dose (50 percent kill): 18 mg/kgCSLNX* NX#00002
intravenous/rabbit lethal dose (50 percent kill): 20 mg/kgFEPRA7 8,205,1949
oral/guinea pig lethal dose (50 percent kill): 17500 µg/kgATXKA8 16,367,1957
oral/rabbit lowest published lethal dose: 25 mg/kgBehavioral: Convulsions or effect on seizure thresholdATXKA8 16,367,1957
oral/rat lethal dose (50 percent kill): 27 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206
skin/rabbit lowest published lethal dose: 79400 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0555206
subcutaneous/Dog lowest published lethal dose: 20 mg/kgFEPRA7 8,205,1949
subcutaneous/guinea pig lethal dose (50 percent kill): 23 mg/kgFEPRA7 8,205,1949
subcutaneous/mouse lowest published lethal dose: 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous/rabbit lowest published lethal dose: 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,367,1957
subcutaneous/rat lethal dose (50 percent kill): 30 mg/kgFEPRA7 8,205,1949

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 270 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 7,41,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 ppm (3 mg/m3) (skin)DTLVS* 3,254,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 ppm (2.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (3 mg/m3);KZW 2 ppm (12 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.8 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (3 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 ppm (3 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (3 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 ppm (3 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (3 mg/m3);short term exposure limit 2 ppm (9 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 ppm (2.8 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,5 ppm (2,8 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 ppm (3 mg/m3), KZG-week 1 ppm (6 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 ppm (3 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 ppm (3 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 ppm (3 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 ppm (3 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYL SUCCINONITRILE-air10H time-weighted average 0.5 ppm (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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