Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorodithioate

RTECS #
WM8400000
CAS #
121-75-5
See: NMAM or OSHA Methods
Updated
June 2018
Molecular Weight
330.38
Molecular Formula
C10H19O6PS2
Synonyms
((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester
1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate
American cyanamid 4,049
Carbethoxy malathion
Carbetovur
Carbetox
Carbofos
Carbophos
Chemathion
Cimexan
Compound 4049
Cythion
Detmol MA
Detmol MA 96%
Dicarboethoxyethyl O,O-dimethyl phosphorodithioate
Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate
Diethyl (dimethoxyphosphinothioylthio)succinate
Diethyl mercaptosuccinate S-ester with O,O-dimethylphosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester
Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate
Diethyl mercaptosuccinate, O,O-dimethyl thiophosphate
Diethyl mercaptosuccinic acid O,O-dimethyl phosphorodithioate
Dithiophosphate de O,O-dimethyle et de S-(1,2-dicarboethoxyethyle) (French)
EL 4049
Emmatos
Emmatos Extra
ENT 17,034
Ethiolacar
Etiol
Experimental insecticide 4049
Extermathion
Forthion
Fosfothion
Fosfotion
Fosfotion 550
Fyfanon
Hilthion
Hilthion 25WDP
Insecticide No. 4049
Karbofos
Kop-thion
Kypfos
Latka 4049 (Czech)
Malacide
Malafor
Malagran
Malakill
Malamar
Malamar 50
Malaphele
Malaphos
Malasol
Malaspray
Malathion
Malathion (ACGIH:OSHA)
Malathion E50
Malathion LV concentrate
Malathion ULV concentrate
Malathon
Malathyl LV concentrate & ULV concentrate
Malation (Polish)
Malatol
Malatox
Maldison
Malmed
Malphos
Maltox
Maltox MLT
Mercaptosuccinic acid diethyl ester
Mercaptothion
Mercaptotion (Spanish)
Moscarda
NCI-C00215
O,O-Dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl)dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl) thiothionophosphate
O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate
O,O-Dimethyl S-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
O,O-Dimethyldithiophosphate diethylmercaptosuccinate
O,O-Dimethyl-S-1,2-(dicarbaethoxyaethyl)-dithiophosphat (German)
O,O-Dimethyl-S-1,2-dikarbetoxylethylditiofosfat (Czech)
O,O-Dwumetylo-S-1,2-bis(karboetoksyetylo)-dwutiofosforan (Polish)
Oleophosphothion
Ortho malathion
Phosphorodithioic acid, O,O-dimethyl ester, S-ester with diethyl mercaptosuccinate
Phosphothion
Prentox malathion 95% spray
Prioderm
S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat (German)
S-(1,2-Bis(carbethoxy)ethyl) O,O-dimethyl dithiophosphate
S-(1,2-Bis(ethoxycarbonyl)ethyl) O,O-dimethyl phosphorodithioate
S-(1,2-Bis(ethoxy-carbonyl)-ethyl)-O,O-dimethyl-dithiofosfaat (Dutch)
S-(1,2-Bis(etossi-carbonil)-etil)-O,O-dimetil-ditiofosfato (Italian)
S-(1,2-Di(ethoxycarbonyl)ethyl) dimethyl phosphorothiolothionate
S-(1,2-Dicarbethoxyethyl) O,O-dimethyldithiophosphate
S-1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyl thiophosphate
Sadofos
Sadophos
SF 60
Siptox I
Sumitox
TAK
TM-4049
Vegfru malatox
Vetiol
Zithiol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysismultiple/other fish200 nL/LJFIBA9 26,13,1985
Cytogenetic Analysislymphocyte/human50 mg/LCYTOAN 54,191,1989
Cytogenetic Analysisleukocyte/human2 mg/LMUREAV 301,13,1993
Cytogenetic Analysisoral/mouse14 mg/kg/7D-continuousFCTOD7 33,309,1995
Cytogenetic Analysisskin/mouse500 mg/kgMUREAV 204,283,1988
Cytogenetic Analysisintraperitoneal/hamster240 mg/kgARTODN 58,152,1986
Cytogenetic Analysislung/hamster76 mg/LGMCRDC 27,95,1981
Cytogenetic Analysisovary/hamster303 mg/LEMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysislymphocyte/mammal (species unspecified)25 mg/LCUSCAM 57,280,1988
Cytogenetic Analysisoral/mouse121 mg/kg/12WMUREAV 513,1,2002
Cytogenetic Analysisintraperitoneal/mouse5 mg/kgMUREAV 514,223,2002
Cytogenetic Analysisoral/mouse5 mg/kgMUREAV 514,223,2002
Cytogenetic Analysisoral/mouse10 mg/kg/5DMUREAV 514,223,2002
Cytogenetic Analysisintraperitoneal/rat25 mg/kg/5D- intermittentMUREAV 725,78,2011
DNA Damageintraperitoneal/rat12.5 mg/kg/5D- intermittentMUREAV 725,78,2011
DNA Damagelymphocyte/rat0.26 mg/L/2HMUREAV 761,10,2014
DNA Damagelymphocyte/rat0.26 mg/L/4HMUREAV 761,10,2014
DNA Damageintraperitoneal/rat199.9 mg/kgTXCYAC 253,8,2008
DNA Damage/Escherichia coli100 mg/LMUREAV 52,161,1978
DNA inhibitionlymphocyte/human70 mg/LHUGEDQ 53,375,1980
Dominant Lethal Testoral/Drosophila melanogaster2500 ng/LFCTOD7 33,309,1995
micronucleus testlymphocyte/human75 mg/LMUREAV 388,85,1997
mutation in microorganisms/Salmonella typhimurium10 mg/L (+enzymatic activation step)CYGEDX 15(3),64,1981
mutation in microorganisms/Bacillus subtilis1 nmol/plate (-enzymatic activation step)MSERDS 5,93,1981
mutation in microorganisms/Other microorganisms100 mg/L (-enzymatic activation step)CYGEDX 15(3),64,1981
other mutation test systemslymphocyte/human70 mg/LENVRAL 41,372,1986
other mutation test systemsleukocyte/human20 µg/LMUREAV 301,13,1993
other mutation test systemslymphocyte/human10 mg/LHUGEDQ 56,189,1980
other mutation test systemsskin/mouse1 gm/kgMUREAV 204,283,1988
other mutation test systemslymphocyte/mammal (species unspecified)50 mg/LCUSCAM 57,280,1988
sister chromatid exchangeoral/mouse10 mg/kg/5DMUREAV 514,223,2002
sister chromatid exchangeoral/mouse121 mg/kg/12WMUREAV 513,1,2002
sister chromatid exchangeintraperitoneal/mouse5 mg/kgMUREAV 514,223,2002
sister chromatid exchangeovary/hamster300 µmol/LJTEHD6 8,939,1981
sister chromatid exchangelung/hamster40 mg/LMUREAV 88,307,1981
sister chromatid exchangelymphocyte/human20 mg/LCYTOAN 54,191,1989
sister chromatid exchangefibroblast/human5 mg/LMUREAV 67,167,1979
sister chromatid exchangeleukocyte/human20 mg/LMUREAV 301,13,1993
specific locus testoral/Drosophila melanogaster4 µg/LFCTOD7 33,309,1995
sperm morphologyintraperitoneal/mouse5 mg/kgMUREAV 514,223,2002
sperm morphologysperm/human50 µmol/L/1HREPTED 22,508,2006
Unscheduled DNA Synthesislymphocyte/human10 mg/LHUGEDQ 56,189,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5550 mg/kg (91D prior to copulation/1-20D pregnant)Reproductive: Specific developmental abnormalities: Body wallJTEHD6 14,267,1984
oral/rat 43920 mg/kg (multigenerations)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
NATUAS 192,464,1961
oral/rat 191 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JFMAAQ 54,452,1967
oral/rat 283 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJFMAAQ 54,452,1967
oral/rabbit 540 mg/kg (28-30D pregnant)Reproductive: Other effects to embryo or fetusMSCREJ 17,743,1989
oral/rat 20 mg/kg (11-17D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FATOAO 52,87,1989
oral/rat 40 mg/kg (11-17D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsFATOAO 52,87,1989
subcutaneous/mouse 420 mg/kg (1-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicNRTXDN 27,1101,2006
unreported route/rat 40 mg/kg (11-17D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
FATOAO 54,80,1991
unreported route/rat 80 mg/kg (2D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 15,458,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 5423 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 1927 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 3448 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 1851 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 13 µmol/L/48HEndocrine: Other changesTXAPA9 272,757,2013
In Vitro/Human, liver Inhibitor Concentration (10 percent kill): 0.62 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 8,47,1994
In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 1.58 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 8,47,1994
In Vitro/Human, liver tumor Inhibitor Concentration (10 percent kill): 0.8 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 2.59 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 1.3 mmol/L/60MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 245,191,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 47.4 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/jrdInhibitor Concentration Low: 10 µmol/L/24HEndocrine: EstrogenicTXAPA9 272,453,2013
In Vitro/jrdInhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TXAPA9 272,453,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 103 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 63.7 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 0.27 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 1.09 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/ntdInhibitor Concentration Low: 50 µg/LIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.

Reproductive: Maternal effects: Oogenesis
TIVIEQ 32,63,2016
In Vitro/paaInhibitor Concentration Low: 75.4 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/phaInhibitor Concentration Low: 10 µmol/L/2HIn Vitro Toxicity Studies: Cell protein synthesisNETEEC 32,58,2011
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 10 µmol/L/6DEndocrine: Other changes

In Vitro Toxicity Studies: Cell protein synthesis
TXAPA9 284,292,2015
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 132000 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Rat, liver Inhibitor Concentration (10 percent kill): 0.33 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 1.02 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 8,47,1994
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.16 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.42 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.05 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 0.34 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.07 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 1.3 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
inhalation/cat Lowest published lethal concentration: 10 mg/m3/4H85GMAT -,56,1982
inhalation/rat lethal concentration (50 percent kill): 43790 µg/m3/4HGISAAA 56(2),80,1991
intraarterial/cat lowest published lethal dose: 1820 µg/kg14KTAK -,693,1964
intraperitoneal/Dog lethal dose (50 percent kill): 1857 mg/kgTXAPA9 15,244,1969
intraperitoneal/guinea pig lethal dose (50 percent kill): 271 mg/kgAEPPAE 236,202,1959
intraperitoneal/hamster lethal dose (50 percent kill): 2400 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 193 mg/kgPSEBAA 129,699,1968
intraperitoneal/rat lethal dose (50 percent kill): 250 mg/kgARZNAD 22,1926,1972
intraperitoneal/rat lowest published toxic dose: 250 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 187,137,2009
intravenous/man lowest published toxic dose: 14 µL/kgVascular: Other changes

Skin: After systemic exposure: Dermatitis, other
JJAMA* 16,367,1992
intravenous/mouse lethal dose (50 percent kill): 184 mg/kgBLLIAX 38,151,1958
intravenous/rat lethal dose (50 percent kill): 50 mg/kgARZNAD 5,626,1955
oral/cattle lethal dose (50 percent kill): 53 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy)
IVEJAC 56,650,1979
oral/chicken lethal dose (50 percent kill): 600 mg/kgBehavioral: Food intake (animal)IJEBA6 9,455,1971
oral/chicken lethal dose (50 percent kill): 1000 mg/kgHBPTO* 2,957,2001
oral/domestic animal lethal dose (50 percent kill): 500 mg/kg85DPAN -,-,1971/1976
oral/duck lethal dose (50 percent kill): 1485 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 570 mg/kgARZNAD 5,626,1955
oral/man lowest published lethal dose: 471 mg/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
ATXKA8 23,11,1967
oral/mouse lethal dose (50 percent kill): 190 mg/kg85GMAT -,56,1982
oral/rabbit lowest published lethal dose: 1200 mg/kgLung, Thorax, or Respiration: Respiratory stimulationAEHA** 99-002-74/1976
oral/rat lethal dose (50 percent kill): 644 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFATOAO 53,64,1990
oral/rat lethal dose (50 percent kill): 290 mg/kg85GMAT -,56,1982
oral/rat lowest published toxic dose: 100 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 92,235,2006
oral/rat lowest published toxic dose: 500 mg/kgBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral/rat lowest published toxic dose: 400 mg/kgGastrointestinal: Changes in structure or function of exocrine pancreas

Liver: Other changes

Endocrine: Hyperglycemia
FCLPH* 22(Suppl 1),36,2008
oral/rat lowest published toxic dose: 100 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 250,27,2008
oral/rat lethal dose (50 percent kill): 450 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
oral/rat lowest published toxic dose: 360 mg/kgLung, Thorax, or Respiration: Respiratory depression

Blood: Hemorrhage

Blood: Methemoglobinemia- Carboxhemoglobinemia
TPKVAL 7,122,1965
oral/wild bird lethal dose (50 percent kill): 400 mg/kgAECTCV 12,355,1983
oral/woman lowest published lethal dose: 246 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Skin: After systemic exposure: Dermatitis, other
AEHLAU 33,240,1978
oral/woman lowest published toxic dose: 300 µL/kgBehavioral: Coma

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Cyanosis
HETOEA 13,271,1994
oral/woman lowest published lethal dose: 8 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
FSINDR 95,89,1998
oral/woman lowest published toxic dose: 200 µL/kgBehavioral: Coma

Gastrointestinal: Changes in structure or function of exocrine pancreas

Lung, Thorax, or Respiration: Respiratory depression
IJMDAI 30,855,1994
skin/guinea pig lethal dose (50 percent kill): 6700 mg/kgAMCYC* 8/1966
skin/mouse lethal dose (50 percent kill): 2330 mg/kgABCHA6 27,684,1963
skin/rabbit lethal dose (50 percent kill): 4100 mg/kg28ZEAL 5,142,1976
skin/rat lethal dose (50 percent kill): >4444 mg/kgPMJMAQ -,155,1957
subcutaneous/guinea pig lethal dose (50 percent kill): 450 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/guinea pig lethal dose (50 percent kill): 450 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous/guinea pig lowest published toxic dose: 112.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TPKVAL 7,122,1965
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 29,184,2008
subcutaneous/mouse lethal dose (50 percent kill): 221 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesteraseOIZAAV 71,6099,1959
subcutaneous/rabbit lethal dose (50 percent kill): 280 mg/kgKidney, Ureter, and Bladder: Urine volume increased

Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/rabbit lethal dose (50 percent kill): 280 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
subcutaneous/rat lethal dose (50 percent kill): 400 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hyperglycemia
TPKVAL 7,122,1965
subcutaneous/rat lethal dose (50 percent kill): 400 mg/kgEye: Lacrimation

Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TPKVAL 7,122,1965
Tank with water/Zebrafish lowest published toxic concentration: 0.01 µmol/L/3DReproductive: Effects on newborn: BehavioralNETOX* 49,50,2015
Tank with water/Zebrafish lowest published toxic concentration: 1 µmol/L/3DReproductive: Specific developmental abnormalities: Central nervous systemNETOX* 49,50,2015
unreported route/cattle lethal dose (50 percent kill): 53 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
IJLAA4 49,314,1979
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,357,1971
unreported route/mammal (species unspecified) lowest published toxic dose: 715 mg/kgImmunological Including Allergic: Decrease in cellular immune response

Blood: Changes in cell count (unspecified)
HBPTO* 1,773,2001
unreported route/mammal (species unspecified) lowest published toxic dose: 0.25 mg/kgImmunological Including Allergic: Decrease in cellular immune responseHBPTO* 1,773,2001
unreported route/mouse lethal dose (50 percent kill): 375 mg/kgGISAAA 50(3),4,1985
unreported route/rat lethal dose (50 percent kill): 124 mg/kgHBPTO* 1,786,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2300 µg/m3/4H/13W- intermittentEndocrine: Other changes

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(8),93,1976
intraperitoneal/rat lowest published toxic dose: 1050 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport
PHTOEH 61,12,1987
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/3D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOSCF2 97,140,2007
intraperitoneal/rat lowest published toxic dose: 4725 mg/kg/5W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Changes in leukocyte (WBC) count
RJENT* 2,85,2008
intraperitoneal/rat lowest published toxic dose: 300 mg/kg/3D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BCLPT* 102,365,2008
multiple/non-mammalian species lowest published toxic dose: 500 mg/m3/7D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXCYAC 212,107,2005
oral/Dog lowest published toxic dose: 210 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFCTXAV 6,185,1968
oral/Dog lowest published toxic dose: 175 mg/kg/4W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 121,96,1957
oral/domestic animal lowest published toxic dose: 150 mg/kg/6D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VHTODE 41,287,1999
oral/human lowest published toxic dose: 19.04 mg/kg/56D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral/mouse lowest published toxic dose: 504 mg/kg/12W- continuousEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
oral/mouse lowest published toxic dose: 1500 mg/kg/15D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
BECTA6 63,575,1999
oral/mouse lowest published toxic dose: 75.6 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 70,222,2014
oral/rabbit lowest published toxic dose: 368 mg/kg/21W- intermittentImmunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
oral/rat lowest published toxic dose: 288 mg/kg/90D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHBPTO* 1,59,2001
oral/rat lowest published toxic dose: 3285 mg/kg/730D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,59,2001
oral/rat lowest published toxic dose: 900 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJDGRAX 18,145,1989
oral/rat lowest published toxic dose: 462 mg/kg/22W- continuousEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
IJEBA6 36,273,1998
oral/rat lowest published toxic dose: 2250 mg/kg/45D- intermittentGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
BECTA6 33,289,1984
oral/rat lowest published toxic dose: 1050 mg/kg/21D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
AECTCV 14,459,1985
oral/rat lowest published toxic dose: 3358 mg/kg/14D- continuousBehavioral: Fluid intake

Blood: Change in clotting factors
JEPOEC 6(1),51,1985
oral/rat lowest published toxic dose: 3200 mg/kg/32D- intermittentBehavioral: Food intake (animal)

Liver: Other changes

Liver: Changes in liver weight
TXCYAC 223,9,2006
oral/rat lowest published toxic dose: 140 mg/kg/2W- intermittentEndocrine: Change in gonadotropins

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BECTA6 18,231,1977
oral/rat lowest published toxic dose: 168 mg/kg/4W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport
CBCPAI 137,29,2004
oral/rat lowest published toxic dose: 168 mg/kg/4W- continuousLiver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Glycolytic
CBCPAI 137,343,2004
oral/rat lowest published toxic dose: 4200 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 82,543,2008
oral/rat lowest published toxic dose: 756 mg/kg/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,633,2010
oral/rat lowest published toxic dose: 756 mg/kg/4W- intermittentEndocrine: Change in gonadotropins

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
FCTOD7 47,1903,2009
oral/rat lowest published toxic dose: 3200 mg/kg/32D- intermittentLiver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCLPH* 21(Suppl 1),98,2007
oral/rat lowest published toxic dose: 3200 mg/kg/32D- intermittentBrain and Coverings: Other degenerative changes

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,1473,2010
skin/rat lowest published toxic dose: 1332 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changesTOXID9 78,86,2004
skin/rat lowest published toxic dose: 1332 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)
JTEHF8 67,331,2004
subcutaneous/guinea pig lowest published toxic dose: 18900 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/guinea pig lowest published toxic dose: 1125 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/mouse lowest published toxic dose: 4200 mg/kg/21D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNRTXDN 27,1101,2006
subcutaneous/rabbit lowest published toxic dose: 11760 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
subcutaneous/rabbit lowest published toxic dose: 2100 mg/kg/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTPKVAL 7,122,1965
subcutaneous/rat lowest published toxic dose: 16800 mg/kg/24W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,122,1965
unreported route/rabbit lowest published toxic dose: 1750 mg/kg/5W- intermittentImmunological Including Allergic: Decrease in humoral immune responseHBPTO* 1,773,2001
unreported route/rat lowest published toxic dose: 5.6 gm/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1035,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 112,107,2015
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 30,103,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,103,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 112,107,2015
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 112,107,2015
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWPMDCAY 10,85,1974
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWJTCTDW 38,47,2000
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWNRTXDN 27,628,2006
TOXICOLOGY REVIEWMUTAEX 20,389,2005
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 674,137,2009
TOXICOLOGY REVIEWFEREAC 74,22478,2009
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWFEREAC 74,47451,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWNBREV* 9,479,1985
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWNRTXDN 33,575,2012
TOXICOLOGY REVIEWTXAPA9 258,309,2012
TOXICOLOGY REVIEWNETEEC 33,608,2011
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWNRTXDN 42,24,2014
TOXICOLOGY REVIEWNRTXDN 39,158,2013
TOXICOLOGY REVIEWTOLED5 210,110,2012
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWMUREAV 770,183,2016
TOXICOLOGY REVIEWMUTAEX 32,491,2017
TOXICOLOGY REVIEWREPTED 71,71,2017

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,128,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3 (skin)DTLVS* 3,148,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 15 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 mg/m3, skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 15 mg/m3, Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3 (skin), total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 15 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3 (skin), total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3 (skin), total dustCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALATHION-air10H time-weighted average 10 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80046; Number of Industries 15; Total Number of Facilities 2146; Number of Occupations 18; Total Number of Employees Exposed 19170; Total Number of Female Employees Exposed 1909
National Occupational Hazard Survey 1974Hazard Code 80046; Number of Industries 13; Total Number of Facilities 1609; Number of Occupations 14; Total Number of Employees Exposed 17242

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100003)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-192,1979
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-62
Page last reviewed: November 16, 2018