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Registry of Toxic Effects of Chemical Substances (RTECS)

Styrene, alpha-methyl-

RTECS #

WL5075300

CAS #

98-83-9

Updated

March 2016

Molecular Weight

118.19

Molecular Formula

C9H10

Synonyms

1-Methyl-1-phenylethylene
2-Phenylpropene
2-Phenylpropylene
alpha-Methyl styrene
alpha-Methyl styrene (ACGIH:OSHA)
alpha-Methyl styrene, fume
alpha-Methylstyreen (Dutch)
alpha-Methylstyrene
alpha-Methyl-styrol (German)
alpha-Metil-stirolo (Italian)
as-Methylphenylethylene
Benzene, (1-methylethenyl)-
beta-Phenylpropene
beta-Phenylpropylene
Isopropenil-benzolo (Italian)
Isopropenyl-benzeen (Dutch)
Isopropenyl-benzol (German)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 91 mg mildAMIHAB 14,387,1956
skin /rabbit 100% moderateAMIHAB 14,387,1956

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human330 µmol/LMUREAV 116,379,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 0.04 gm/m3/1HTPKVAL 6,6,1964
inhalation/guinea pig Lowest published lethal concentration: 3000 ppm28ZRAQ -,131,1960
inhalation/human lowest published toxic concentration: 600 ppmEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGH* -,203,1990
inhalation/human lowest published toxic concentration: 600 ppmOlfaction: Other olfaction effects

Eye: Other eye effects
AMIHAB 14,387,1956
inhalation/mouse lowest published toxic concentration: 0.4 gm/m3/2HCardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Fatty liver degeneration
TPKVAL 6,6,1964
inhalation/mouse lowest published toxic concentration: 0.4 gm/m3Skin: After systemic exposure: Dermatitis, otherTPKVAL 6,6,1964
inhalation/rat Lowest published lethal concentration: 3000 ppm28ZRAQ -,131,1960
oral/mouse lethal dose (50 percent kill): 4500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 28(12),14,1963
oral/mouse lethal dose (50 percent kill): 50000 mg/kgVCVGH* -,203,1990
oral/mouse lowest published lethal dose: 3000 mg/kgCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 6,6,1964
oral/rat lethal dose (50 percent kill): 4900 mg/kgAMIHAB 14,387,1956
skin/rabbit lowest published lethal dose: 16 mL/kgUCDS** 5/24/1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 3000 ppm/7H/24W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGH* -,203,1990
inhalation/rat lowest published toxic concentration: 3000 ppm/7H/24W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGH* -,203,1990
inhalation/rat lowest published toxic concentration: 50 mg/m3/6H/22W- intermittentBehavioral: Muscle contraction or spasticity

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 28(12),14,1963
inhalation/rat lowest published toxic concentration: 5 mg/m3/24H/13W- continuousBrain and Coverings: Recordings from specific areas of CNS

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
GISAAA 31(2),3,1966
inhalation/rat lowest published toxic concentration: 0.025 gm/m3/91D- intermittentLiver: Liver function tests impairedTPKVAL 6,6,1964
inhalation/rat lowest published toxic concentration: 0.025 gm/m3/213D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration

Blood: Changes in spleen
TPKVAL 6,6,1964
inhalation/rat lowest published toxic concentration: 0.025 gm/m3/183D- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 6,6,1964
oral/mouse lowest published toxic dose: 15 gm/kg/30D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainGISAAA 29(4),24,1964
oral/rat lowest published toxic dose: 1400 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,203,1990
oral/rat lowest published toxic dose: 15 gm/kg/30D- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in leukocyte (WBC) count
GTPZAB 23(6),38,1979
oral/rat lowest published toxic dose: 10.01 gm/kg/2W- intermittentEar: Change in cochlear structure or functionARTODN 79,346,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 101,347,2013
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 101,347,2013
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 100 ppm (480 mg/m3)DTLVS* 3,170,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (242 mg/m3), short term exposure limit 100 ppm (483 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (246 mg/m3);KZW 100 ppm (492 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (246 mg/m3), short term exposure limit 100 ppm(492 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (240 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 246 mg/m3 (50 ppm);short term exposure limit 492 mg/m3 (100 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (250 mg/m3), short term exposure limit 100 ppm (490 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (240 mg/m3), VLE 100 ppm (492 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 50 ppm (250 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 246 mg/m3, short term exposure limit 492 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm (492 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (240 mg/m3), short term exposure limit 100 ppm (485 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (240 mg/m3);short term exposure limit 100 ppm (485 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (242 mg/m3); short term exposure limit 100 ppm (483 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (242 mg/m3); short term exposure limit 100 ppm (483 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 20 ppm (98 mg/m3);short term exposure limit 50 ppm (245 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (250 mg/m3), KZG-week 100 ppm (500 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 100 ppm (480 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 240 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (246 mg/m3);short term exposure limit 100 ppm (491 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 100 ppm (480 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 100 ppm (480 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 100 ppm (480 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 100 ppm (480 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-METHYLSTYRENE-air10H time-weighted average 50 ppm;short term exposure limit 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1533; Number of Industries 3; Total Number of Facilities 354; Number of Occupations 4; Total Number of Employees Exposed 3214
National Occupational Hazard Survey 1974Hazard Code M1533; Number of Industries 20; Total Number of Facilities 1933; Number of Occupations 32; Total Number of Employees Exposed 24824

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9275
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
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