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Registry of Toxic Effects of Chemical Substances (RTECS)

Strychnine

RTECS #

WL2275000

CAS #

57-24-9

Updated

October 2017

Molecular Weight

334.45

Molecular Formula

C21H22N2O2

Synonyms

Boomer-rid
Certox
Dolco mouse cereal
Gopher bait
Gopher-gitter
Hare-Rid
Kwik-kil
Mole death
Mouse-nots
Mouse-rid
Mouse-tox
Pied piper mouse seed
RCRA waste number P108
Ro-Dex
Sanaseed
Stricnina (Italian)
Strychnidin-10-one (9CI)
Strychnin (German)
Strychnine (ACGIH:OSHA)
Strychnos

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/human1 mmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human0.1 mmol/l/48HMUREAV 696,21,2010

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intramuscular/rat 500 µg/kg (5D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Stillbirth
PSEBAA 100,555,1959
oral/rat 2.5 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NETEEC 27,855,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 309 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor Inhibitor Concentration Low: 0.1 mmol/LIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TIVIEQ 26,511,2012
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 34.0 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 143 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/paaInhibitor Concentration Low: 176 µmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 132 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Rat, liver Inhibitor Concentration Low: 0.1 mmol/LIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TIVIEQ 26,511,2012
intramuscular/mouse lethal dose (50 percent kill): 628 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
CHHTAT 54,234,1974
intramuscular/rat lethal dose (50 percent kill): 1400 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
CHHTAT 54,234,1974
intraperitoneal/mouse lethal dose (50 percent kill): 980 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JPETAB 128,176,1960
intraperitoneal/mouse lowest published lethal dose: 2 mg/kgBehavioral: Convulsions or effect on seizure thresholdJOETD7 149,783,2013
intraperitoneal/mouse lowest published toxic dose: 2.5 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity
JOETD7 76,145,2001
intraperitoneal/rat lowest published lethal dose: 2 mg/kgBehavioral: Muscle contraction or spasticityJOETD7 77,143,2001
intraperitoneal/rat lethal dose (50 percent kill): 0.25 mg/kgHBPTO* 1,157,2001
intraperitoneal/rat lowest published toxic dose: 0.2 mg/kgBehavioral: Convulsions or effect on seizure thresholdEURNE* 13,257,2003
intraperitoneal/rat lowest published lethal dose: 4 mg/kgBehavioral: Convulsions or effect on seizure thresholdPYTOEY 15,959,2008
intraperitoneal/rat lethal dose (50 percent kill): 1100 µg/kgBehavioral: Convulsions or effect on seizure thresholdJPETAB 58,239,1936
intraspinal/mouse lowest published toxic dose: 327.3 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 326,633,2008
intraspinal/mouse lowest published toxic dose: 654.5 µg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 326,633,2008
intraspinal/mouse lowest published toxic dose: 109.09 ng/kgBehavioral: AnalgesiaJPETAB 326,633,2008
intravenous/cat lowest published lethal dose: 330 µg/kgHBAMAK 4,1403,1935
intravenous/Dog lethal dose (50 percent kill): 800 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 126,41,1959
intravenous/mouse lowest published toxic dose: 1.05 mg/kgLiver: Change in gall bladder structure or function

Liver: Other changes
TOLED5 160,179,2006
intravenous/mouse lowest published lethal dose: 1.31 mg/kgLiver: Change in gall bladder structure or function

Liver: Other changes
TOLED5 160,179,2006
intravenous/mouse lethal dose (50 percent kill): 0.41 mg/kgENTOX* ,706,2005
intravenous/rabbit lethal dose (50 percent kill): 400 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
JPETAB 126,41,1959
intravenous/rat lethal dose (50 percent kill): 582 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
CHHTAT 54,234,1974
intravenous/rat lowest published toxic dose: 0.42 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXCYAC 173,249,2002
intravenous/rat lowest published lethal dose: 0.58 mg/kgBehavioral: Convulsions or effect on seizure thresholdTXCYAC 173,249,2002
intravenous/rat lethal dose (50 percent kill): 0.57 mg/kgHBPTO* 1,157,2001
oral/cat lethal dose (50 percent kill): 500 µg/kgBehavioral: Convulsions or effect on seizure thresholdRMVEAG 154,137,1978
oral/chicken lowest published lethal dose: 30 mg/kgFDWU** -,-,1931
oral/child lowest published toxic dose: 24 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
PECAE5 15,264,1999
oral/Dog lethal dose (50 percent kill): 500 µg/kgBehavioral: Convulsions or effect on seizure thresholdRMVEAG 154,137,1978
oral/domestic bird lowest published lethal dose: 2500 µg/kgFDWU** -,-,1931
oral/duck lethal dose (50 percent kill): 3 mg/kgTXAPA9 20,57,1971
oral/frog lowest published lethal dose: 2100 µg/kgFDWU** -,-,1931
oral/human lowest published lethal dose: 30 mg/kgPCOC** -,1073,1966
oral/human lethal dose (50 percent kill): 30 mg/kgENTOX* ,104,2005
oral/man lowest published lethal dose: 30 mg/kgPEMNDP 9,771,1991
oral/man lowest published lethal dose: 5143 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Change in rate
JTCTDW 30,269,1992
oral/mouse lethal dose (50 percent kill): 2 mg/kgIJEBA6 19,1075,1981
oral/mouse lowest published lethal dose: 2 mg/kgBehavioral: Convulsions or effect on seizure thresholdBIMEL* 16,5377,2008
oral/pigeon lethal dose (50 percent kill): 21 mg/kgTXAPA9 20,57,1971
oral/quail lethal dose (50 percent kill): 23 mg/kgTXAPA9 20,57,1971
oral/rabbit lowest published lethal dose: 600 µg/kgHBAMAK 4,1403,1935
oral/rat lethal dose (50 percent kill): 2350 µg/kgJAPMA8 31,113,1942
oral/wild bird lethal dose (50 percent kill): 16 mg/kgTXAPA9 20,57,1971
parenteral/mouse lethal dose (50 percent kill): 1060 µg/kgARZNAD 11,657,1961
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHBPTO* 1,157,2001
subcutaneous/cat lowest published lethal dose: 250 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Irritability
CHHTAT 54,234,1974
subcutaneous/chicken lowest published lethal dose: 3 mg/kgHBAMAK 4,1403,1935
subcutaneous/Dog lowest published lethal dose: 350 µg/kgHBAMAK 4,1403,1935
subcutaneous/domestic bird lowest published lethal dose: 1 mg/kgFDWU** -,-,1931
subcutaneous/duck lowest published lethal dose: 1 mg/kgHBAMAK 4,1403,1935
subcutaneous/frog lowest published lethal dose: 35 µg/kgHBAMAK 4,1403,1935
subcutaneous/guinea pig lowest published lethal dose: 3200 µg/kgHBAMAK 4,1403,1935
subcutaneous/mouse lethal dose (50 percent kill): 474 µg/kgBehavioral: Convulsions or effect on seizure thresholdAPSXAS 7,329,1970
subcutaneous/mouse lowest published toxic dose: 1.2 mg/kgBehavioral: AnticonvulsantJOETD7 78,73,2001
subcutaneous/mouse lowest published toxic dose: 1.2 mg/kgBehavioral: Convulsions or effect on seizure thresholdPHREP* 61,245,2009
subcutaneous/pigeon lowest published lethal dose: 1 mg/kgFDWU** -,-,1931
subcutaneous/rabbit lowest published lethal dose: 400 µg/kgFDWU** -,-,1931
subcutaneous/rat lethal dose (50 percent kill): 1200 µg/kgRPTOAN 31,260,1968
subcutaneous/rat lowest published toxic dose: 2 mg/kgBehavioral: Convulsions or effect on seizure thresholdFATOAO 49,13,1986
Tank with water/Zebrafish lowest published toxic concentration: 501.68 mg/L/18HReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral
NETEEC 34,587,2012
unreported route/child lowest published lethal dose: 0.75 mg/kgHBPTO* 1,158,2001
unreported route/human lowest published lethal dose: 0.71 mg/kgHBPTO* 1,158,2001
unreported route/man lowest published lethal dose: 1103 µg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 500 µg/kgIGAYAY 112,861,1980
unreported route/rat lowest published lethal dose: 1 mg/kgPEMNDP 9,771,1991

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.15 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWJTCTDW 38,71,2000
TOXICOLOGY REVIEWTPHSDY 23,519,2002
TOXICOLOGY REVIEWTPHSDY 24,199,2003
TOXICOLOGY REVIEWTOXIA6 44,405,2004
TOXICOLOGY REVIEWEMCPT* 2,89,2005
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWISMEA* 10,142,2008
TOXICOLOGY REVIEWBJPCBM 154,606,2008
TOXICOLOGY REVIEWHTCWA* 2,199,
TOXICOLOGY REVIEWCGHEP* 5,648,2007
TOXICOLOGY REVIEWNEUCL* 18,215,2000
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNRTXDN 33,1473,2012
TOXICOLOGY REVIEWFTRPAE 115,155,I2

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,278,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.15 mg/m3DTLVS* 3,235,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.15 mg/m3;KZW 0.6 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.15 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.15 mg/m3, short term exposure limit 0.45 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.15 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 0.15 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.15 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg/m3;short term exposure limit 0.45 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.15 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,15 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.15 mg/m3, JAN1999
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.15 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.15 mg/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.15 mg/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.15 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.15 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.15 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.15 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO STRYCHNINE-air10H time-weighted average 0.15 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 70060; Number of Industries 1; Total Number of Facilities 46; Number of Occupations 2; Total Number of Employees Exposed 511; Total Number of Female Employees Exposed 325
National Occupational Hazard Survey 1974Hazard Code 70060; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 1; Total Number of Employees Exposed 18

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Strychnine, 5016
On EPA IRIS database
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