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Registry of Toxic Effects of Chemical Substances (RTECS)

Sodium bisulfite (1:1)

RTECS #

VZ2000000

CAS #

7631-90-5; 57414-01-4; 69098-86-8; 89830-27-3; 91829-63-9

Updated

October 2015

Molecular Weight

104.06

Molecular Formula

HO3S·Na

Synonyms

Bisulfite de sodium (French)
Hydrogen sulfite sodium
Monosodium sulfite
Sodium acid sulfite
Sodium bisulfite
Sodium bisulfite (ACGIH)
Sodium bisulphite
Sodium hydrogen sulfite
Sodium sulhydrate
Sulfurous acid, monosodium salt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human375 µmol/LTECSDY 8,39,1984
Cytogenetic Analysisembryo/hamster40 mmol/LCNREA8 48,7246,1988
DNA Damage/Other microorganisms3 mole/LBBRCA9 39,156,1970
DNA Damage/Other microorganisms3 mole/L/96H-continuousNARHAD 8,4777,1980
DNA Damage/Saccharomyes cerevisiae3200 mmol/LJBCHA3 252,2566,1977
micronucleus testlymphocyte/human100 µmol/LMUREAV 298,63,1992
morphological transformembryo/hamster5 mmol/LCRNGDP 11,1869,1990
mutation in microorganisms/Salmonella typhimurium100 mmol/L (+enzymatic activation step)TCMUD8 5,195,1985
mutation in microorganisms/Escherichia coli1 mole/L (-enzymatic activation step)BBRCA9 39,983,1970
mutation in microorganisms/Haemophilus influenzae200 mmol/L (-enzymatic activation step)ABMPAC 17,115,1980
mutation in microorganisms/Other microorganisms3 mole/L (-enzymatic activation step)BBRCA9 39,156,1970
mutation in microorganisms/Other microorganisms180 mmol/L (-enzymatic activation step)GENTAE 68,603,1971
other mutation test systemslymphocyte/human50 µmol/LMUREAV 298,63,1992
sister chromatid exchangelymphocyte/human50 µmol/LMUREAV 298,63,1992
sister chromatid exchangeembryo/hamster500 µmol/LCRNGDP 11,1869,1990
specific locus testother cell types/non-mammalian species4 mole/LPNASA6 79,1388,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, skin Inhibitor Concentration Low: 40 mg/well/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,616,2014
intraperitoneal/Dog lethal dose (50 percent kill): 244 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
CLPTAT 9,328,1968
intraperitoneal/guinea pig lethal dose (50 percent kill): 779 mg/kgTXAPA9 44,251,1978
intraperitoneal/hamster lethal dose (50 percent kill): 487 mg/kgCEHYAN 22,64,1977
intraperitoneal/mouse lethal dose (50 percent kill): 675 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
CLPTAT 9,328,1968
intraperitoneal/rabbit lethal dose (50 percent kill): 300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
CLPTAT 9,328,1968
intraperitoneal/rat lethal dose (50 percent kill): 475 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold
PNASA6 70,3655,1973
intravenous/hamster lethal dose (50 percent kill): 95 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
JPETAB 101,101,1951
intravenous/mouse lethal dose (50 percent kill): 130 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
JPETAB 101,101,1951
intravenous/rabbit lethal dose (50 percent kill): 65 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
JPETAB 101,101,1951
intravenous/rat lethal dose (50 percent kill): 115 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
JPETAB 101,101,1951
oral/rat lethal dose (50 percent kill): 2 gm/kg85INA8 6,1408,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 4381 mg/kg/21D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 44(10),62,1979
intravenous/rabbit lowest published toxic dose: 450 mg/kg/3W- intermittentVascular: Thromobosis distant from injection site

Skin: After systemic exposure: Dermatitis, other
JPETAB 101,101,1951

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 54,131,1992
TOXICOLOGY REVIEWIJTOFN 22,63,2003
TOXICOLOGY REVIEWCODEDG 57,11,2007
TOXICOLOGY REVIEWMUREAV 751,304,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,320,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SODIUM BISULFITE-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1055; Number of Industries 144; Total Number of Facilities 22338; Number of Occupations 110; Total Number of Employees Exposed 296327; Total Number of Female Employees Exposed 119535
National Occupational Hazard Survey 1974Hazard Code M1055; Number of Industries 147; Total Number of Facilities 23628; Number of Occupations 92; Total Number of Employees Exposed 133191

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Mouse specific locus; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Rodent heritable translocation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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