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Registry of Toxic Effects of Chemical Substances (RTECS)

Silver

RTECS #

VW3500000

CAS #

7440-22-4

Updated

September 2013

Molecular Weight

107.87

Molecular Formula

Ag

Synonyms

Argentum
C.I. 77820
L-3
Shell silver
Silber (German)
Silver (ACGIH:OSHA)
Silver atom

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 11 gm/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
NATWAY 42,75,1955
implant/rat toxic dose: 2570 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
NATWAY 42,75,1955
implant/rat lowest published toxic dose: 2400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 16,439,1956
multiple/rat lowest published toxic dose: 330 mg/kg/43W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ZEKBAI 63,586,1960

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig Lethal dose: >5 gm/kgGTPZAB 27(12),33,1983
oral/mouse lethal dose (50 percent kill): 100 mg/kgENTOX* ,17,2005
oral/mouse Lethal dose: >10 gm/kgGTPZAB 27(12),33,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8400 mg/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOXID9 -,90,2008
oral/rat lowest published toxic dose: 8400 mg/kg/28D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOXID9 -,90,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWMIBUBI 9,321,1975
TOXICOLOGY REVIEWPTPAD4 1,127,1976
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEWCRTXB2 37,237,2007
TOXICOLOGY REVIEWENTOX* -,17,2005
TOXICOLOGY REVIEWTOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEWHBTME* ,809,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,335,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.01 mg/m3DTLVS* 3,231,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.1 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg/m3 (dust), MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.1 mg/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.01 mg/m3, dust, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.01 mg/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, KZG-week 0.8 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.01 mg(Ag)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.01 mg(Ag)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.01 mg(Ag)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.01 mg(Ag)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILVER, metal and soluble compds-air10H time-weighted average 0.01 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M1804; Number of Industries 4; Total Number of Facilities 156; Number of Occupations 9; Total Number of Employees Exposed 3937; Total Number of Female Employees Exposed 2435
National Occupational Exposure Survey 1983Hazard Code 68730; Number of Industries 118; Total Number of Facilities 13582; Number of Occupations 76; Total Number of Employees Exposed 204921; Total Number of Female Employees Exposed 37439
National Occupational Hazard Survey 1974Hazard Code 68730; Number of Industries 53; Total Number of Facilities 2163; Number of Occupations 54; Total Number of Employees Exposed 19343

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180430/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121
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