Silica, amorphous fumed

RTECS #
VV7310000
CAS #
112945-52-5; 50926-93-7; 67256-35-3
See: NMAM or OSHA Methods
Updated
June 2017
Molecular Weight
60.09
Molecular Formula
O2Si
Synonyms
Acticel
Aerosil
Amorphous silica dust
Aquafil
Cab-O-grip II
Cab-O-sil
Cab-O-sperse
Cataloid
Colloidal silica
Colloidal silicon dioxide
Davison SG-67
Dicalite
Dri-Die insecticide 67
ENT 25,550
Fossil flour
Fumed silica
Fumed silicon dioxide
Ludox
Nalcoag
Nyacol
Nyacol 1430
Nyacol 830
Pyrogenic colloidal silica
Santocel
SG-67
Silica, amorphous
Silicic anhydride
Silikill
Synthetic amorphous silica, fumed
Vulkasil

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintratracheal/rat30 mg/kg/3M- intermittentTXCYAC 303,177,2013

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, erythrocytes Inhibitor Concentration (50 percent kill): 0.29 gm/L/2HIn Vitro Toxicity Studies: Hemolysis in vitroTIVIEQ 1,239,1987
In Vitro/Mouse, macrophage Inhibitor Concentration (50 percent kill): 34 mg/L/17HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 1,77,1987
intraperitoneal/rat lowest published lethal dose: 50 mg/kgAHBAAM 136,1,1952
intratracheal/mouse lowest published lethal dose: 96.77 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOPADD 33,745,2005
intratracheal/mouse lowest published toxic dose: 96.77 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOPADD 33,745,2005
intratracheal/mouse lowest published toxic dose: 50 mg/kgLung, Thorax, or Respiration: Changes in lung weightTOLED5 175,24,2007
intratracheal/mouse lowest published toxic dose: 2 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 175,24,2007
intratracheal/mouse lowest published toxic dose: 2 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TOLED5 182,97,2008
intratracheal/mouse lowest published toxic dose: 50 mg/kgLung, Thorax, or Respiration: Fibrosing alveolitis

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 182,97,2008
intratracheal/rat lowest published lethal dose: 10 mg/kgAHBAAM 136,1,1952
intravenous/rat lethal dose (50 percent kill): 15 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaBSIBAC 44,1685,1968
oral/rat lethal dose (50 percent kill): 3160 mg/kgARSIM* 20,9,1966

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 154 mg/m3/6H/4W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Other proteins
FAATDF 16,590,1991
inhalation/rat lowest published toxic concentration: 5.41 mg/m3/5D- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 45,1856,2007
inhalation/rat lowest published toxic concentration: 1.39 mg/m3/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 45,1856,2007
intratracheal/rat lowest published toxic dose: 30 mg/kg/3M- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Liver: Other changes
TXCYAC 303,177,2013
intratracheal/rat lowest published toxic dose: 75 mg/kg/60W- intermittentLiver: TumorsTXCYAC 303,177,2013
oral/mouse lowest published toxic dose: 2500 mg/kg/5D- intermittentImmunological Including Allergic: Increase in humoral responseTXCYAC 282,82,2011

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 68,41,1997
TOXICOLOGY REVIEWNTIS** CONF-691001
TOXICOLOGY REVIEWECRVE8 6,197,1988
TOXICOLOGY REVIEWPTPAD4 120,35,2008
TOXICOLOGY REVIEWTXCYAC 294,61,2012
TOXICOLOGY REVIEWMUREAV 763,181,2015
TOXICOLOGY REVIEWMUTAEX 32,203,2017

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-dust in airtime-weighted average 20 mppcfDTLWS* 3,33,1973
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 mg/m3 (respirable dust), JUL2008
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 6 mg/m3 (inhal. dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.4 mg/m3 (resp. dust), OCT2007

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, amorphous, 7501
OSHA ANALYTICAL METHOD #ID-125G
Page last reviewed: November 16, 2018