Silica, amorphous fumed

RTECS #

VV7310000

CAS #

112945-52-5; 50926-93-7; 67256-35-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

60.09

Molecular Formula

O₂Si

Synonyms

Acticel
Aerosil
Amorphous silica dust
Aquafil
Cab-O-grip II
Cab-O-sil
Cab-O-sperse
Cataloid
Colloidal silica
Colloidal silicon dioxide
Davison SG-67
Dicalite
Dri-Die insecticide 67
ENT 25,550
Fossil flour
Fumed silica
Fumed silicon dioxide
Ludox
Nalcoag
Nyacol
Nyacol 1430
Nyacol 830
Pyrogenic colloidal silica
Santocel
SG-67
Silica, amorphous
Silicic anhydride
Silikill
Synthetic amorphous silica, fumed
Vulkasil

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	intratracheal/rat	30 mg/kg/3M- intermittent	TXCYAC 303,177,2013

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, erythrocytes	Inhibitor Concentration (50 percent kill): 0.29 gm/L/2H	In Vitro Toxicity Studies: Hemolysis in vitro	TIVIEQ 1,239,1987
In Vitro/Mouse, macrophage	Inhibitor Concentration (50 percent kill): 34 mg/L/17H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 1,77,1987
intraperitoneal/rat	lowest published lethal dose: 50 mg/kg		AHBAAM 136,1,1952
intratracheal/mouse	lowest published lethal dose: 96.77 mg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	TOPADD 33,745,2005
intratracheal/mouse	lowest published toxic dose: 96.77 mg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOPADD 33,745,2005
intratracheal/mouse	lowest published toxic dose: 50 mg/kg	Lung, Thorax, or Respiration: Changes in lung weight	TOLED5 175,24,2007
intratracheal/mouse	lowest published toxic dose: 2 mg/kg	Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOLED5 175,24,2007
intratracheal/mouse	lowest published toxic dose: 2 mg/kg	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases	TOLED5 182,97,2008
intratracheal/mouse	lowest published toxic dose: 50 mg/kg	Lung, Thorax, or Respiration: Fibrosing alveolitis Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOLED5 182,97,2008
intratracheal/rat	lowest published lethal dose: 10 mg/kg		AHBAAM 136,1,1952
intravenous/rat	lethal dose (50 percent kill): 15 mg/kg	Lung, Thorax, or Respiration: Acute pulmonary edema	BSIBAC 44,1685,1968
oral/rat	lethal dose (50 percent kill): 3160 mg/kg		ARSIM* 20,9,1966

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 154 mg/m³/6H/4W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Other proteins	FAATDF 16,590,1991
inhalation/rat	lowest published toxic concentration: 5.41 mg/m³/5D- intermittent	Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	FCTOD7 45,1856,2007
inhalation/rat	lowest published toxic concentration: 1.39 mg/m³/5D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 45,1856,2007
intratracheal/rat	lowest published toxic dose: 30 mg/kg/3M- intermittent	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Liver: Other changes	TXCYAC 303,177,2013
intratracheal/rat	lowest published toxic dose: 75 mg/kg/60W- intermittent	Liver: Tumors	TXCYAC 303,177,2013
oral/mouse	lowest published toxic dose: 2500 mg/kg/5D- intermittent	Immunological Including Allergic: Increase in humoral response	TXCYAC 282,82,2011

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 68,41,1997
TOXICOLOGY REVIEW		NTIS** CONF-691001
TOXICOLOGY REVIEW		ECRVE8 6,197,1988
TOXICOLOGY REVIEW		PTPAD4 120,35,2008
TOXICOLOGY REVIEW		TXCYAC 294,61,2012
TOXICOLOGY REVIEW		MUREAV 763,181,2015
TOXICOLOGY REVIEW		MUTAEX 32,203,2017
TOXICOLOGY REVIEW		RTOPDW 60,93,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-dust in air	time-weighted average 20 mppcf	DTLWS* 3,33,1973
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 mg/m³ (respirable dust), JUL2008
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 6 mg/m³ (inhal. dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2.4 mg/m³ (resp. dust), OCT2007

Status in Federal Agencies

Organization	Reference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, amorphous, 7501
OSHA ANALYTICAL METHOD #ID-125G

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health