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Registry of Toxic Effects of Chemical Substances (RTECS)

Pyrophosphoric acid, tetraethyl ester

RTECS #

UX6825000

CAS #

107-49-3

Updated

September 2013

Molecular Weight

290.22

Molecular Formula

C8H20O7P2

Synonyms

Bis-O,O-diethylphosphoric anhydride
Bladan
Diphosphoric acid tetraethyl ester
EA 1285
ENT 18,771
Ethyl pyrophosphate, tetra-
Fosvex
Grisol
HEPT
Hexamite
Killex
Kilmite 40
Lethalaire G-52
Lirohex
Mortopal
Nifos
Nifos T
O,O,O,O-Tetraethyl-difosfaat (Dutch)
O,O,O,O-Tetraetil-pirofosfato (Italian)
Pyrophosphate de tetraethyle (French)
RCRA waste number P111
TEPP (ACGIH:OSHA)
Tetraaethylpyrophosphorsaeureester (German)
Tetraethyl diphosphate
Tetraethyl pyrofosfaat (Dutch)
Tetraethyl pyrophosphate
Tetraethyl pyrophosphate (OSHA)
Tetraethyldifosfat (Czech)
Tetraethylpyrofosfat (Czech)
Tetrastigmine
Tetron
Tetron-100
Vapotone

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/human lowest published lethal dose: 286 µg/kgPeripheral Nerve and Sensation: Paresthesia

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
CMEP** -,1,1956
intramuscular/man lowest published lethal dose: 380 µg/kgJCINAO 37,350,1958
intramuscular/rat lethal dose (50 percent kill): 1800 µg/kgJCINAO 37,350,1958
intraperitoneal/mouse lethal dose (50 percent kill): 830 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAIPTAK 121,104,1959
intraperitoneal/rat lethal dose (50 percent kill): 650 µg/kgFEPRA7 6,353,1947
intravenous/mouse lethal dose (50 percent kill): 200 µg/kgBJPCAL 9,299,1954
intravenous/pigeon lethal dose (50 percent kill): 180 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Eye: Other eye effects
AIPTAK 102,371,1955
intravenous/rabbit lowest published lethal dose: 300 µg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
BJPCAL 8,466,1953
intravenous/rat lethal dose (50 percent kill): 300 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesCJBPAZ 34,197,1956
oral/duck lethal dose (50 percent kill): 3560 µg/kgTXAPA9 47,451,1979
oral/guinea pig lethal dose (50 percent kill): 2300 µg/kgJPETAB 105,156,1952
oral/human lowest published lethal dose: 1429 µg/kgPeripheral Nerve and Sensation: Paresthesia

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
CMEP** -,1,1956
oral/human lowest published toxic dose: 309 µg/kgBehavioral: Wakefulness

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Other changes
CMEP** -,1,1956
oral/man lowest published lethal dose: 1700 µg/kgJCINAO 37,350,1958
oral/mouse lethal dose (50 percent kill): 3 mg/kgABCHA6 27,684,1963
oral/rat lethal dose (50 percent kill): 500 µg/kgPHJOAV 185,361,1960
oral/wild bird lethal dose (50 percent kill): 1300 µg/kgTXAPA9 21,315,1972
parenteral/frog lethal dose (50 percent kill): 34 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
AIPTAK 124,212,1960
parenteral/human lowest published toxic dose: 71 µg/kgBehavioral: Wakefulness

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Other changes
CMEP** -,1,1956
skin/duck lethal dose (50 percent kill): 64 mg/kgTXAPA9 47,451,1979
skin/mouse lethal dose (50 percent kill): 8 mg/kgABCHA6 27,684,1963
skin/rabbit lowest published lethal dose: 17 µL/kgBehavioral: Excitement

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0534856
skin/rat lethal dose (50 percent kill): 2400 µg/kgTXAPA9 14,515,1969
subcutaneous/guinea pig lethal dose (50 percent kill): 700 µg/kgBJPCAL 14,5,1959
subcutaneous/mouse lethal dose (50 percent kill): 500 µg/kgARZNAD 29,875,1979
subcutaneous/rabbit lethal dose (50 percent kill): 2 mg/kgIAEC** 17JUN1974
subcutaneous/rat lethal dose (50 percent kill): 279 µg/kgFAATDF 4,S195,1984
unreported route/rabbit lethal dose (50 percent kill): 1 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseAJOPAA 53,512,1962
unreported route/rat lethal dose (50 percent kill): 1120 µg/kg30ZDA9 -,379,1971

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCRTXB2 3,289,1975
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWIRXPAT 3,219,1964
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,588,2005
TOXICOLOGY REVIEWCCACL* 21,673,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.004 ppm (0.05 mg/m3)DTLWS* 3,28,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.004 ppm (0.05 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.004 ppm (0.047 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.005 ppm (0.05 mg/m3);KZW 0.05 ppm (0.5 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.004 ppm (0.048 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.004 ppm (0.05 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.004 ppm (0.05 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.005 ppm (0.06 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.004 ppm (0.05 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.004 ppm (0.05 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.004 ppm (0.05 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.004 ppm (0.047 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,004 ppm (0,05 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.005 ppm (0.05 mg/m3), KZG-week 0.01 ppm (0.1 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.05 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEPP-air10H time-weighted average 0.05 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 71680; Number of Industries 1; Total Number of Facilities 9; Number of Occupations 14; Total Number of Employees Exposed 1434

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetraethyl pyrophosphate, 2504
On EPA IRIS database
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