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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propyn-1-ol

RTECS #

UK5075000

CAS #

107-19-7

Updated

September 2013

Molecular Weight

56.07

Molecular Formula

C3H4O

Synonyms

1-Propyne-3-ol
2-Propynyl alcohol
Acetylene carbinol
Agrisynth PA
Ethynylcarbinol
Methanol, ethynyl-
Propargyl alcohol
Propargyl alcohol (ACGIH:OSHA)
RCRA waste number P102

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster400 µmol/LMUREAV 320,273,1994
Cytogenetic Analysisovary/hamster10 mmol/L/16H (+/-enzymatic activation step)HPV358 -,-,2003
mutation in microorganisms/Salmonella typhimurium10 µmol/plate (+enzymatic activation step)UNMI** DA85-04850

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 3 gm/m3GTPZAB 32(10),25,1988
inhalation/mouse lethal concentration (50 percent kill): 2000 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 8,97,1966
inhalation/mouse Lowest published lethal concentration: 1.25 gm/m3/2HVascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 8,97,1966
inhalation/mouse lethal concentration (50 percent kill): 1.75 gm/m3/2HTPKVAL 8,97,1966
inhalation/mouse lethal concentration (50 percent kill): 1750 mg/m3Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,122,1984
inhalation/rat lethal concentration (50 percent kill): 1800 mg/m3Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,122,1984
inhalation/rat lethal concentration (50 percent kill): 873 ppm/2HGAFCC*
inhalation/rat lethal concentration (50 percent kill): 1.8 gm/m3/2HGastrointestinal: Necrotic changes

Gastrointestinal: Other changes

Liver: Fatty liver degeneration
TPKVAL 8,97,1966
inhalation/rat lethal concentration (50 percent kill): 1040 ppm/1HHPV358 -,-,2003
inhalation/rat Lowest published lethal concentration: 1.25 gm/m3/2HPeripheral Nerve and Sensation: Fasciculations

Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 8,97,1966
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation

Eye: Other eye effects
TPKVAL 8,97,1966
oral/guinea pig lethal dose (50 percent kill): 60 mg/kgDTLVS* 4,346,1980
oral/mammal (species unspecified) lethal dose (50 percent kill): 50 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 50 mg/kgLung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,122,1984
oral/mouse lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage
TPKVAL 8,97,1966
oral/rat lethal dose (50 percent kill): 20 mg/kg38MKAJ 2C,4672,1982
oral/rat lethal dose (50 percent kill): 55 mg/kgEndocrine: Other changes

Blood: Hemorrhage
HPV358 -,-,2003
oral/rat lethal dose (50 percent kill): 55 mg/kgLung, Thorax, or Respiration: Respiratory depression

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,122,1984
skin/rabbit lethal dose (50 percent kill): 16 mg/kgSkin: After systemic exposure: Dermatitis, other38MKAJ 2C,4672,1982
skin/rabbit lethal dose (50 percent kill): 88 mg/kgHPV358 -,-,2003
skin/rabbit lowest published lethal dose: 15 mg/kgHPV358 -,-,2003
subcutaneous/rabbit lowest published lethal dose: 25 mg/kgBDBU** -,-,1930
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 53 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 100 mg/m3/4H/60D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,122,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 5 mg/m3/4H/28W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,122,1994
inhalation/mouse lowest published toxic concentration: 25300 ppb/6H/14D- intermittentOlfaction: Other olfaction effectsJJATDK 15,207,1995
inhalation/mouse lowest published toxic concentration: 16 ppm/13W- continuousOlfaction: Other olfaction effects

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV358 -,,2003
inhalation/mouse lowest published toxic concentration: 230 mg/m3/2H/3W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 8,97,1966
inhalation/mouse lowest published toxic concentration: 0.25 gm/m3/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 8,97,1966
inhalation/rat lowest published toxic concentration: 0.25 gm/m3/14D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 8,97,1966
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/91D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 8,97,1966
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/61D- intermittentLiver: Liver function tests impairedTPKVAL 8,97,1966
inhalation/rat lowest published toxic concentration: 32 ppm/90D- continuousOlfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
HPV358 -,,2003
inhalation/rat lowest published toxic concentration: 24.6 ppm/90D- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
HPV358 -,,2003
inhalation/rat lowest published toxic concentration: 230 mg/m3/2H/3W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 8,97,1966
inhalation/rat lowest published toxic concentration: 7 mg/m3/4H/22W- intermittentVascular: BP lowering not characterized in autonomic section

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
TPKVAL 8,97,1966
oral/rat lowest published toxic dose: 1365 mg/kg/13W- continuousLiver: Other changesHPV358 -,,2003
oral/rat lowest published toxic dose: 4550 mg/kg/13W- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV358 -,,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (2 mg/m3) (skin)DTLVS* 3,215,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (2.3 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (4.7 mg/m3);KZW 4 ppm (9.4 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (2.3 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.3 mg/m3), short term exposure limit 3 ppm (7 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (2 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (4.7 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (2.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (2 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (2.3 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (2,3 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (4.7 mg/m3), KZG-week 4 ppm (9.4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (2.3 mg/m3);short term exposure limit 3 ppm (7 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPARGYL ALCOHOL-air10H time-weighted average 1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 62000; Number of Industries 56; Total Number of Facilities 3447; Number of Occupations 38; Total Number of Employees Exposed 54359; Total Number of Female Employees Exposed 19934
National Occupational Hazard Survey 1974Hazard Code 62000; Number of Industries 7; Total Number of Facilities 471; Number of Occupations 11; Total Number of Employees Exposed 30791

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #97
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