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Registry of Toxic Effects of Chemical Substances (RTECS)

Propionitrile

RTECS #

UF9625000

CAS #

107-12-0

Updated

July 2016

Molecular Weight

55.09

Molecular Formula

C3H5N

Synonyms

Cyanoethane
Ether cyanatus
Ethyl cyanide
Ethylkyanid (Czech)
Hydrocyanic ether
Propanenitrile
Propannitril (Czech)
Propionic nitrile
Propiononitrile
RCRA waste number P101

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,898,1986
skin /rabbit 500 mg/24H mild85JCAE -,898,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsother cell types/mouse643 mg/L/24H (-enzymatic activation step)HPV108 -,-,2003
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster51 ppmMUREAV 259,165,1991
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae15100 mg/LMUREAV 224,31,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 200 ppm/6H (6-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 20,365,1993
inhalation/rat 100 ppm/6H (6-20D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemFAATDF 20,365,1993
intraperitoneal/hamster 238 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 23,317,1981
intraperitoneal/hamster 238 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 23,325,1981
intraperitoneal/hamster 238 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 23,325,1981
oral/rat 180 mg/kg (10D pregnant)Reproductive: Other effects to embryo or fetusTXAPA9 163,149,2000
oral/rat 1120 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 7,33,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 163 ppm/1HLiver: Other changesCTOXAO 18,991,1981
inhalation/rat Lowest published lethal concentration: 500 ppm/4HAMIHBC 4,119,1951
inhalation/rat lethal concentration (50 percent kill): 3300 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
HPV108 -,-,2003
intraperitoneal/guinea pig lethal dose (50 percent kill): 10 mg/kg38MKAJ 2C,4872,1982
intraperitoneal/mouse lethal dose (50 percent kill): 28 mg/kgEye: Corneal damage

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 59,589,1981
intraperitoneal/rat lethal dose (50 percent kill): 25 mg/kg38MKAJ 2C,4872,1982
intraperitoneal/rat lethal dose (50 percent kill): 189.7 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
intravenous/rabbit lowest published lethal dose: 50 mg/kgCRSBAW 1,251,1889
oral/guinea pig lethal dose (50 percent kill): 25 mg/kg38MKAJ 2C,4872,1982
oral/mouse lethal dose (50 percent kill): 35797 µg/kgNEZAAQ 39,423,1984
oral/rat lethal dose (50 percent kill): 39 mg/kgAMIHBC 4,119,1951
oral/rat lethal dose (50 percent kill): 122.9 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,2314,2009
oral/rat lethal dose (50 percent kill): 83.6 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
oral/rat lethal dose (50 percent kill): 40 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV108 -,-,2003
skin/guinea pig lowest published lethal dose: 5 gm/kg38MKAJ 2C,4872,1982
skin/rabbit lethal dose (50 percent kill): 210 µL/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 40 mg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes

Liver: Other changes
HPV108 -,-,2003
subcutaneous/frog lowest published lethal dose: 8 gm/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
subcutaneous/guinea pig lethal dose (50 percent kill): 18100 µg/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Nausea or vomiting
MELAAD 47,192,1956
subcutaneous/rabbit lowest published lethal dose: 60 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
AIPTAK 5,161,1899
subcutaneous/rat lethal dose (50 percent kill): 150.7 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
FCTOD7 59,595,2013
unreported route/Dog lowest published lethal dose: 50 mg/kgCRSBAW 1,251,1889

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 209 ppm/6H/14W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 5,113,1985
inhalation/rat lowest published toxic concentration: 60 ppm/14W- intermittentBehavioral: Ataxia

Endocrine: Changes in spleen weight
HPV108 -,-,2003
inhalation/rat lowest published toxic concentration: 120 ppm/14W- intermittentBehavioral: Ataxia

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HPV108 -,-,2003
inhalation/rat lowest published toxic concentration: 209 ppm/14W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV108 -,-,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPIONITRILE-air10H time-weighted average 6 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8903
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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