2-Propenoic acid, butyl ester

RTECS #
UD3150000
CAS #
141-32-2
See: NMAM or OSHA Methods
Updated
September 2013
Molecular Weight
128.19
Molecular Formula
C7H12O2
Synonyms
Acrylic acid n-butyl ester
Acrylic acid, butyl ester
Butyl 2-propenoate
Butyl acrylate
Butylester kyseliny akrylove (Czech)
n-Butyl acrylate
n-Butyl acrylate (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg mildUCDS** 4/5/1973
eye /rabbit 500 mg/24H mild85JCAE -,370,1986
skin /rabbit 10 mg/24H open irritation test mildAMIHBC 4,119,1951
skin /rabbit 500 mg open irritation test mildUCDS** 4/5/1973
skin /woman 0.1%/48HCODEDG 57,21,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 135 ppm/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 3,443,1983
inhalation/rat 135 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0534614
inhalation/rat 200 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOSCF2 48,240,1999
inhalation/rat 200 ppm (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 7800 mg/m3GISAAA 51(5),61,1986
inhalation/mouse lethal concentration (50 percent kill): 7800 mg/m3/2H85GMAT -,28,1982
inhalation/rat lethal concentration (50 percent kill): 2730 ppm/4HOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
inhalation/rat lowest published toxic concentration: 5.05 gm/m3/6HLiver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
intraperitoneal/mouse lethal dose (50 percent kill): 200 mL/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS05220809
intraperitoneal/rat lethal dose (50 percent kill): 550 mg/kgAMPMAR 36,58,1975
oral/mouse lethal dose (50 percent kill): 5880 mg/kgLung, Thorax, or Respiration: Other changesGTPZAB 25(11),57,1981
oral/rabbit lowest published lethal dose: 2 mL/kgNTIS** OTS0520808
oral/rat lethal dose (50 percent kill): 900 mg/kg85GMAT -,28,1982
skin/rabbit lethal dose (50 percent kill): 2 mL/kgTXAPA9 28,313,1974
skin/rat lowest published lethal dose: 1700 mg/kgPJPPAA 32,223,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 211 ppm/6H/13W- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555423
oral/rat lowest published toxic dose: 13650 mg/kg/13W- intermittentLiver: Changes in liver weightTOXID9 2,33,1982

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 39,67,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,359,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,67,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate EvidenceIMEMDT 71,359,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,359,1999
TOXICOLOGY REVIEWEVHPAZ 11,141,1975

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (5 mg/m3), short term exposure limit 5 ppm (26 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (11 mg/m3);KZW 10 ppm (53 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (11 mg/m3), short term exposure limit 10 ppm (53 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (11 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 11 mg/m3 (2 ppm);short term exposure limit 53 mg/m3 (10 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (11 mg/m3), short term exposure limit 10 ppm (53 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (11 mg/m3), VLE 10 ppm (53 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (11 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 11 mg/m3, short term exposure limit 53 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (11 mg/m3), short term exposure limit 10 ppm (53 mg/m3), sen, NOV2011
Occupational Exposure Limit-JAPANs2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (55 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (55 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (52 mg/m3), sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (55 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (10.5 mg/m3); short term exposure limit 10 ppm (52 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 20 mg/m3, short term exposure limit 70 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (50 mg/m3);short term exposure limit 15 ppm (80 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (11 mg/m3), KZG-week 4 ppm (22 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (5 mg/m3);short term exposure limit 5 ppm (26 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL ACRYLATE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84295; Number of Industries 33; Total Number of Facilities 2948; Number of Occupations 40; Total Number of Employees Exposed 39848; Total Number of Female Employees Exposed 6688
National Occupational Hazard Survey 1974Hazard Code 84295; Number of Industries 28; Total Number of Facilities 2222; Number of Occupations 33; Total Number of Employees Exposed 16374

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
Page last reviewed: November 16, 2018