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Registry of Toxic Effects of Chemical Substances (RTECS)

Propene, 1,3-dichloro-

RTECS #

UC8310000

CAS #

542-75-6; 8022-76-2

Updated

April 2017

Molecular Weight

110.97

Molecular Formula

C3H4Cl2

Synonyms

1,3-Dichloro-2-propene
1,3-Dichloropropene
1,3-Dichloropropene (ACGIH)
1,3-Dichloropropene, technical grade
1,3-Dichloropropene-1
1,3-Dichloropropylene
3-Chloroallyl chloride
3-Chloropropenyl chloride
alpha,gamma-Dichloropropylene
alpha-Chloroallyl chloride
D-D 92
DD 95
Dorlone II
gamma-Chloroallyl chloride
NCI-C03985
RCRA waste number U084
Telone
Telone II
Telone II soil fumigant

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster49100 µg/LEMMUEG 13,60,1989
DNA Damageintraperitoneal/mouse150 mg/kgMUREAV 419,13,1998
mutation in mammalian somatic cellslymphocyte/mouse3 mg/LSCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium10 µmol/plate (-enzymatic activation step)ENMUDM 2,59,1980
mutation in microorganisms/Salmonella typhimurium0.004 µmol/L/3D (-enzymatic activation step)MUREAV 572,98,2005
mutation in microorganisms/Salmonella typhimurium50 mg/L/2H (-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium100 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
other mutation test systems/Escherichia coli1 mmol/LMUREAV 203,81,1988
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5750 ppmENMUDM 7,325,1985
sister chromatid exchangeovary/hamster900 nmol/LCNJGA8 22,681,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 60 ppm/6H/5D/2YTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FAATDF 12,418,1989
oral/mouse lowest published toxic dose: 31200 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-269,1985
oral/mouse lowest published toxic dose: 15600 mg/kg/104W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral/mouse lowest published toxic dose: 31200 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral/mouse lowest published toxic dose: 15600 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** PB85-230449/AS
oral/rat lowest published toxic dose: 15600 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTPTR* NTP-TR-269,1985
oral/rat lowest published toxic dose: 15600 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB85-230449/AS
oral/rat lowest published toxic dose: 7800 mg/kg/104W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB85-230449/AS
oral/rat lowest published toxic dose: 7800 mg/kg/104W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTIS** PB85-230449/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 400 ppm/7HAIHAAP 38,217,1977
inhalation/human lowest published toxic concentration: 1500 ppmLung, Thorax, or Respiration: CoughVCVGH* -,474,1990
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 3.88 gm/m3/4HFEREAC 65,1869,2000
inhalation/mouse lethal concentration (50 percent kill): 3220 mg/m3/2HVCVGH* -,473,1990
inhalation/rat Lowest published lethal concentration: 1000 ppm/2HEye: LacrimationAIHAAP 38,217,1977
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CRTOEC 13,1096,2000
intraperitoneal/mouse lowest published lethal dose: 700 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOXID9 1,90,2001
intraperitoneal/mouse lowest published lethal dose: 700 mg/kgTOXID9 1,90,2001
intraperitoneal/rat lethal dose (50 percent kill): 175 mg/kgTOXID9 5,2,1985
oral/mammal (species unspecified) lethal dose (50 percent kill): 224 mg/kgFEREAC 65,1869,2000
oral/mouse lethal dose (50 percent kill): 640 mg/kgENTOX* -,11,2005
oral/rat lethal dose (50 percent kill): 470 mg/kgENTOX* -,11,2005
skin/rabbit lethal dose (50 percent kill): 333 mg/kgFEREAC 65,1869,2000
skin/rat lethal dose (50 percent kill): 775 mg/kgFMCHA2 -,C103,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 90 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 11,207,1988
inhalation/rat lowest published toxic concentration: 90 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 11,207,1988
oral/Dog lowest published toxic dose: 3731 mg/kg/13W- continuousBlood: Microcytosis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RTOPDW 30,233,1999
oral/Dog lowest published toxic dose: 5460 mg/kg/1Y- continuousBlood: Microcytosis with or without anemia

Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
RTOPDW 30,233,1999
oral/mouse lowest published toxic dose: 1365 mg/kg/13W- continuousCardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,224,1996
oral/rat lowest published toxic dose: 455 mg/kg/26W- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
GISAAA 39(1),94,1974
oral/rat lowest published toxic dose: 1365 mg/kg/13W- continuousGastrointestinal: Alteration in gastric secretion

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 32,224,1996
unreported route/rat lowest published toxic dose: 750 mg/kg/30D- intermittentLiver: Other changes

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,115,2004
unreported route/rat lowest published toxic dose: 1500 mg/kg/60D- intermittentLiver: Other changes

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOXID9 78,115,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 41,113,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,933,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 41,113,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,933,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,933,1999
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,11,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWFEREAC 73,8212,2008
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,151,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (4.5 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.11 ppm (0.5 mg/m3);KZW 0.44 ppm (2 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (4.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (5 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (5 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (5 mg/m3), skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (4.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (4.6 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.11 ppm (0.5 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-DICHLOROPROPENE-air8H Carcinogen time-weighted average 1 ppm (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code X3912; Number of Industries 3; Total Number of Facilities 48; Number of Occupations 14; Total Number of Employees Exposed 2162; Total Number of Female Employees Exposed 33

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110765/AS)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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