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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1-methoxy-

RTECS #

UB7700000

CAS #

107-98-2

Updated

October 2014

Molecular Weight

90.14

Molecular Formula

C4H10O2

Synonyms

1-Methoxy-2-propanol
alpha-Propylene glycol monomethyl ether
Dowanol 33B
Dowanol PM
Dowanol PM glycol ether
Dowtherm 209
Glycol ether PM
Methoxy ether of propylene glycol
Methyl proxitol
PGME
Poly-Solve MPM
Propasol solvent M
Propylene glycol methyl ether
Propylene glycol monomethyl ether
Propylene glycol monomethyl ether (ACGIH)
Propylenglykol-monomethylaether (German)
Ucar Solvent LM (Obs.)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,625,1986
skin /rabbit 500 mg open irritation test mildUCDS** 11/15/1971

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 3000 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFAATDF 4,784,1984
inhalation/rat 3000 ppm/6H (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Physical
TOSCF2 50,249,1999
oral/mouse 3.3 gm/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86170578
oral/mouse 3.3 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB86170578
oral/mouse 3.3 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86170578
oral/mouse 115.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86170578
oral/rabbit 936 mg/kg (7-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOSCF2 71,217,2003
oral/rat 50501.25 mg/kg (15D prior to copulation)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TIHEEC 21,33,2005
oral/rat 59395.5 mg/kg (15D prior to copulation)Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TIHEEC 21,33,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 15000 ppm/7HBehavioral: SleepAMIHBC 9,509,1954
inhalation/human lowest published toxic concentration: 3000 ppmOlfaction: Tumors

Behavioral: General anesthetic

Gastrointestinal: Nausea or vomiting
NPIRI* 1,105,1974
inhalation/human lowest published toxic concentration: 2580 mg/m3Eye: LacrimationVCVGK* -,169,1984
inhalation/human lowest published toxic concentration: 7540 mg/m3Eye: Conjunctiva irritationVCVGK* -,169,1984
inhalation/human lowest published toxic concentration: 830 mg/m3/1HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,170,1984
inhalation/mouse lowest published toxic concentration: 1000 ppmLiver: Other changesTOXID9 72,178,2003
inhalation/mouse lowest published toxic concentration: 3000 ppmBehavioral: AntianxietyTOXID9 72,178,2003
inhalation/rabbit Lowest published lethal concentration: 15000 ppm/7HAMIHBC 9,509,1954
inhalation/rat lowest published toxic concentration: 18400 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,169,1984
inhalation/rat lethal concentration (50 percent kill): 10000 ppm/5HNPIRI* 1,105,1974
inhalation/rat lowest published toxic concentration: 3000 ppmBehavioral: AntianxietyTOXID9 72,178,2003
inhalation/rat lowest published toxic concentration: 1000 ppmLiver: Other changesTOXID9 72,178,2003
inhalation/rat lowest published toxic concentration: 1000 ppmKidney, Ureter, and Bladder: Other changesTOXID9 72,178,2003
intraperitoneal/mouse Lethal dose: >500 mg/kgCBCCT* 4,110,1952
intraperitoneal/rat lethal dose (50 percent kill): 3720 mg/kg38MKAJ 2C,3977,1982
intravenous/Dog lethal dose (50 percent kill): 2 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
intravenous/mouse lethal dose (50 percent kill): 5300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
intravenous/rabbit lethal dose (50 percent kill): 1200 mg/kgARZNAD 22,569,1972
intravenous/rat lethal dose (50 percent kill): 4200 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
oral/Dog lethal dose (50 percent kill): 5 gm/kgARZNAD 22,569,1972
oral/mouse lethal dose (50 percent kill): 11700 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
oral/rabbit lethal dose (50 percent kill): 5700 mg/kgARZNAD 22,569,1972
oral/rat lethal dose (50 percent kill): 6600 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,169,1984
oral/rat lowest published lethal dose: 3739 mg/kgEye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0520402
skin/rabbit lethal dose (50 percent kill): 13 gm/kgNPIRI* 1,105,1974
subcutaneous/rabbit lethal dose (50 percent kill): 5 gm/kgARZNAD 22,569,1972
subcutaneous/rat lethal dose (50 percent kill): 7800 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 6000 ppm/7H/16W- intermittentBehavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,509,1954
inhalation/monkey lowest published toxic concentration: 10000 ppm/4H/13W- intermittentLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,509,1954
inhalation/mouse lowest published toxic concentration: 3000 ppm/6H/11D- intermittentLiver: Changes in liver weightTXAPA9 61,368,1981
inhalation/rabbit lowest published toxic concentration: 3000 ppm/6H/13W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 3,627,1983
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/11D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
TXAPA9 61,368,1981
inhalation/rat lowest published toxic concentration: 3000 ppm/6H/13W- intermittentLiver: Changes in liver weightFAATDF 3,627,1983
inhalation/rat lowest published toxic concentration: 11000 mg/m3/6H/9D- intermittentBrain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
VCVGK* -,170,1994
inhalation/rat lowest published toxic concentration: 2200 mg/m3/12D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,170,1994
multiple/human lowest published toxic dose: 100 ppm/3H/2W- intermittentOlfaction: Other olfaction effectsTOLED5 135,S30,2002
multiple/human lowest published toxic dose: 150 ppm/3H/2W- intermittentOlfaction: Other olfaction effects

Eye: Conjunctiva irritation
TOLED5 135,S30,2002
oral/mouse lowest published toxic dose: 40 mL/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral/mouse lowest published toxic dose: 40 mL/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral/rat lowest published toxic dose: 40 mL/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral/rat lowest published toxic dose: 40 mL/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral/rat lowest published toxic dose: 280435.2 mg/kg/64D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TIHEEC 21,33,2005
skin/rabbit lowest published toxic dose: 900 mL/kg/90D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,170,1994
skin/rabbit lowest published toxic dose: 455 mL/kg/13W- intermittentBehavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 9,509,1954

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWCRTXB2 30,307,2000
TOXICOLOGY REVIEWTOLED5 140-141,249,2003
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWTOLED5 199,203,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (360 mg/m3)DTLWS* 3,27,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (187 mg/m3);KZW 50 ppm (187 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (375 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 150 ppm (568 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (185 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 375 mg/m3 (100 ppm);short term exposure limit 568 mg/m3 (150 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 100 ppm (370 mg/m3), short term exposure limit 150 ppm (560 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (375 mg/m3), VLE 150 ppm (568 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 100 ppm (370 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 375 mg/m3, short term exposure limit 568 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (185 mg/m3), short term exposure limit 150 ppm (568 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (360 mg/m3), short term exposure limit 150 ppm (540 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 50 ppm (180 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (369 mg/m3); short term exposure limit 150 ppm (553 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (190 mg/m3);short term exposure limit 75 ppm (300 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (360 mg/m3), KZG-week 200 ppm (720 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 375 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (375 mg/m3);short term exposure limit 150 ppm (560 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 100 ppm;short term exposure limit 150 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81815; Number of Industries 204; Total Number of Facilities 25947; Number of Occupations 133; Total Number of Employees Exposed 373990; Total Number of Female Employees Exposed 110572
National Occupational Hazard Survey 1974Hazard Code 81815; Number of Industries 44; Total Number of Facilities 5953; Number of Occupations 36; Total Number of Employees Exposed 26413

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #99
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