Propane, 2,2'-oxybis-
RTECS #
TZ5425000
CAS #
Updated
April 2015
Molecular Weight
102.20
Molecular Formula
C6H14O
Synonyms
2-Isopropoxypropane
Diisopropyl oxide
Ether isopropylique (French)
Ether, isopropyl
Isopropyl ether
Isopropyl ether (ACGIH:OSHA)
Izopropylowy eter (Polish)
Diisopropyl oxide
Ether isopropylique (French)
Ether, isopropyl
Isopropyl ether
Isopropyl ether (ACGIH:OSHA)
Izopropylowy eter (Polish)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 363 mg open irritation test | mild | UCDS** 4/10/1968 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 3095 ppm/6H (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Musculoskeletal system | JTEHD6 49,29,1996 |
| inhalation/rat | 10000 mg/m3 (10D prior to copulation) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | VCVGK* -,266,1994 |
| inhalation/rat | 3095 ppm (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV206 -,-,2005 |
| inhalation/rat | 3095 ppm (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV376 -,-,2006 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/guinea pig | Lowest published lethal concentration: 60000 ppm/1H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV206 -,-,2005 |
| inhalation/guinea pig | lowest published toxic concentration: 1 pph | Behavioral: General anesthetic | HPV376 -,-,2006 |
| inhalation/guinea pig | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV376 -,-,2006 |
| inhalation/human | lowest published toxic concentration: 500 ppm | Olfaction: Other olfaction effects | HPV376 -,-,2006 |
| inhalation/human | lowest published toxic concentration: 1250 mg/m3/3M | Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough | VCVGK* -,267,1994 |
| inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 130 gm/m3 | GTPZAB 32(10),25,1988 | |
| inhalation/monkey | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/monkey | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV376 -,-,2006 |
| inhalation/monkey | lowest published toxic concentration: 1 pph | Behavioral: General anesthetic | HPV376 -,-,2006 |
| inhalation/monkey | Lowest published lethal concentration: 60000 ppm/1H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV206 -,-,2005 |
| inhalation/mouse | lethal concentration (50 percent kill): 130800 mg/m3 | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/mouse | lethal concentration (50 percent kill): 131 gm/m3 | Behavioral: General anesthetic Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | GTPZAB 19(10),55,1975 |
| inhalation/rabbit | lethal concentration (50 percent kill): 121 gm/m3 | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | GTPZAB 19(10),55,1975 |
| inhalation/rabbit | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/rabbit | Lowest published lethal concentration: 60000 ppm/1H | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV206 -,-,2005 |
| inhalation/rabbit | lowest published toxic concentration: 1 pph | Behavioral: General anesthetic | HPV376 -,-,2006 |
| inhalation/rabbit | Lowest published lethal concentration: 6 pph | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV376 -,-,2006 |
| inhalation/rabbit | lethal concentration (50 percent kill): 120600 mg/m3 | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/rat | lethal concentration (50 percent kill): 161700 mg/m3 | Behavioral: General anesthetic Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,266,1994 |
| inhalation/rat | lowest published toxic concentration: 500 ppm/6H | Lung, Thorax, or Respiration: Other changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 90,374,2006 |
| inhalation/rat | lethal concentration (50 percent kill): 162 gm/m3 | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | GTPZAB 19(10),55,1975 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 812 mg/kg | SCCUR* -,5,1961 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 6 gm/kg | GTPZAB 32(10),25,1988 | |
| oral/mouse | lethal dose (50 percent kill): 3600 mg/kg | VCVGK* -,266,1994 | |
| oral/rabbit | lowest published lethal dose: 5 gm/kg | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression | HPV206 -,-,2005 |
| oral/rabbit | lowest published lethal dose: 6 gm/kg | Behavioral: Altered sleep time (including change in righting reflex) | JIHTAB 21(3),72,1939 |
| oral/rabbit | lowest published lethal dose: 5 gm/kg | Behavioral: General anesthetic Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | HPV376 -,-,2006 |
| oral/rat | lethal dose (50 percent kill): 4.5 gm/kg | HPV376 -,-,2006 | |
| skin/rabbit | lethal dose (50 percent kill): >2 gm/kg | HPV376 -,-,2006 | |
| skin/rabbit | lethal dose (50 percent kill): 20 mL/kg | UCDS** 4/10/1968 | |
| unreported route/mouse | lethal dose (50 percent kill): 3600 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | GTPZAB 19(10),55,1975 |
| unreported route/rat | lethal dose (50 percent kill): 5880 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Muscle contraction or spasticity | GTPZAB 19(10),55,1975 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rabbit | lowest published toxic concentration: 2090 mg/m3/5H/22W- intermittent | Behavioral: Muscle contraction or spasticity Liver: Liver function tests impaired | GTPZAB 19(10),55,1975 |
| inhalation/rabbit | lowest published toxic concentration: 2090 mg/m3/5H/152D- intermittent | Cardiac: Other changes Lung, Thorax, or Respiration: Emphysema Blood: Changes in spleen | VCVGK* -,267,1994 |
| inhalation/rabbit | lowest published toxic concentration: 507 mg/m3/5H/152D- intermittent | Liver: Multiple effects | VCVGK* -,267,1994 |
| inhalation/rat | lowest published toxic concentration: 500 ppm/5D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 90,374,2006 |
| inhalation/rat | lowest published toxic concentration: 7100 ppm/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in kidney weight | HPV206 -,-,2005 |
| inhalation/rat | lowest published toxic concentration: 3300 ppm/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | HPV376 -,-,2006 |
| inhalation/rat | lowest published toxic concentration: 450 ppm/13W- intermittent | Behavioral: Change in motor activity (specific assay) | HPV376 -,-,2006 |
| inhalation/rat | lowest published toxic concentration: 7500 mg/m3/30D- intermittent | Behavioral: Irritability Brain and Coverings: Increased intracranial pressure | VCVGK* -,266,1994 |
| inhalation/rat | lowest published toxic concentration: 10000 mg/m3/4H/10D- intermittent | Endocrine: Effect on menstrual cycle Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | VCVGK* -,266,1994 |
| inhalation/rat | lowest published toxic concentration: 2090 mg/m3/5H/152D- intermittent | Brain and Coverings: Other degenerative changes Liver: Liver function tests impaired | VCVGK* -,267,1994 |
| inhalation/rat | lowest published toxic concentration: 2090 mg/m3/5H/22W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Blood: Other changes | GTPZAB 19(10),55,1975 |
| inhalation/rat | lowest published toxic concentration: 3300 ppm/6H/13W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | JTEHD6 49,29,1996 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 250 ppm;short term exposure limit 310 ppm | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ENTOX* -,387,2005 | |
| TOXICOLOGY REVIEW | MUREAV 762,76,2014 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 250 ppm (1050 mg/m3) | DTLVS* 3,142,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1300 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 250 ppm (1050 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 250 ppm (1055 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 310 ppm (1319 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 250 ppm (1050 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 250 ppm, short term exposure limit 320 ppm, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 250 ppm (1050 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 200 ppm (850 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 250 ppm (1050 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 250 ppm (1025 mg/m3), short term exposure limit 310 ppm (1320 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 250 ppm (1050 mg/m3);short term exposure limit 310 ppm (1320 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 250 ppm (1040 mg/m3); short term exposure limit 310 ppm (1300 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 125 ppm (525 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 250 ppm (1047 mg/m3); short term exposure limit 310 ppm (1298 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 1300 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 100 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 200 ppm (850 mg/m3), KZG-week 400 ppm (1700 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1050 mg/m3, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 500 ppm (2100 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 250 ppm (1060 mg/m3);short term exposure limit 310 ppm (1310 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 500 ppm (2100 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 500 ppm (2100 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 500 ppm (2100 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 500 ppm (2100 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL ETHER-air | 10H time-weighted average 500 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 25905; Number of Industries 5; Total Number of Facilities 130; Number of Occupations 11; Total Number of Employees Exposed 3253; Total Number of Female Employees Exposed 1126 | |
| National Occupational Hazard Survey 1974 | Hazard Code 25905; Number of Industries 11; Total Number of Facilities 952; Number of Occupations 11; Total Number of Employees Exposed 12024 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health