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Registry of Toxic Effects of Chemical Substances (RTECS)

Propanenitrile, 2-methyl-

RTECS #

TZ4900000

CAS #

78-82-0

Updated

July 2015

Molecular Weight

69.12

Molecular Formula

C4H7N

Synonyms

2-Cyanopropane
2-Methylpropanenitrile
2-Methylpropionitrile
alpha-Methylpropanenitrile
Dimethylacetonitrile
Isopropyl cyanide
Isopropyl nitrile
Isopropylkyanid (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 380 mg open irritation test mildUCDS** 10/29/1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HAIHAAP 23,95,1962
inhalation/rat lethal concentration (10 percent kill): 1173 ppm/1HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
HPV108 -,-,2003
inhalation/rat lethal concentration (50 percent kill): >1000 ppm/1HHPV108 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
ZAARAM 19,225,1969
oral/mouse lethal dose (50 percent kill): 25 mg/kgARTODN 55,47,1984
oral/mouse lowest published lethal dose: 51.83 mg/kgTOLED5 196S,S220,2010
oral/rabbit lethal dose (50 percent kill): 14 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ZAARAM 19,225,1969
oral/rat lethal dose (50 percent kill): 77 mg/kgHPV108 -,-,2003
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Respiratory depression
HPV108 -,-,2003
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Vascular: Regional or general arteriolar or venous dilation
38MKAJ 2C,4874,1982
skin/guinea pig lowest published lethal dose: 5 gm/kg38MKAJ 2C,4874,1982
skin/rabbit lethal dose (50 percent kill): 200 mg/kgZAARAM 19,225,1969
subcutaneous/frog lowest published lethal dose: 4800 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
subcutaneous/rabbit lowest published lethal dose: 9 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
AIPTAK 5,161,1899

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYRONITRILE-air10H time-weighted average 8 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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