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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,2-epoxy-3-isopropoxy-

RTECS #

TZ3500000

CAS #

4016-14-2

Updated

September 2013

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

((1-Methylethoxy)methyl)oxirane
(Isopropoxymethyl)oxirane
1,2-Epoxy-3-isopropoxypropane
2,3-Epoxypropyl isopropyl ether
3-Isopropyloxypropylene oxide
Glycidyl isopropyl ether
IGE (OSHA)
Isopropyl epoxypropyl ether
Isopropyl glycidyl ether
Isopropyl glycidyl ether (ACGIH:OSHA)
NCI-C56439
Oxirane, ((1-methylethoxy)methyl)- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 92 mg moderateAMIHAB 14,250,1956
eye /rabbit 20 mg/24H moderate85JCAE -,772,1986
skin /rabbit 459 mg/3D moderateAMIHAB 14,250,1956
skin /rabbit 100 mg/24H moderate85JCAE -,772,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
heritable translocation testoral/Drosophila melanogaster2900 ppmEMMUEG 23,51,1994
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+/-enzymatic activation step)MUREAV 172,105,1986
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
other mutation test systems/Escherichia coli3300 µmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster2500 µmol/LMUREAV 249,55,1991
specific locus testoral/Drosophila melanogaster2900 ppmEMMUEG 23,51,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1500 ppm/4HLung, Thorax, or Respiration: Other changes

Liver: Other changes
AMIHAB 14,250,1956
inhalation/rat lethal concentration (50 percent kill): 1100 ppm/8HLung, Thorax, or Respiration: Other changes

Liver: Other changes
AMIHAB 14,250,1956
oral/mouse lethal dose (50 percent kill): 1300 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 4200 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
skin/rabbit lethal dose (50 percent kill): 9650 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 14,250,1956

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 ppm/7H/10W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainAMIHAB 14,250,1956

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppm;short term exposure limit 75 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (240 mg/m3)DTLVS* 3,142,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (238 mg/m3), short term exposure limit 75 ppm (356 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (241 mg/m3), short term exposure limit 75 ppm (361 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (240 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 50 ppm (240 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (240 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (240 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm (360 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (240 mg/m3);short term exposure limit 75 ppm (360 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (238 mg/m3); short term exposure limit 75 ppm (356 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (238 mg/m3); short term exposure limit 75 ppm (356 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (240 mg/m3), KZG-week 75 ppm (360 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 30 ppm (240 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (240 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL GLYCIDYL ETHER-airceiling concentration 50 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl glycidyl ether, 1620
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
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