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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,2-epoxy-

RTECS #

TZ2975000

CAS #

75-56-9

Updated

April 2017

Molecular Weight

58.09

Molecular Formula

C3H6O

Synonyms

1,2-Epoxypropane
1,2-Epoxypropane (ACGIH:OSHA)
1,2-Propylene oxide
2,3-Epoxypropane
AD 6 (suspending agent)
Epoxypropane
Ethylene oxide, methyl-
Methyl ethylene oxide
Methyl oxirane
Methyloxacyclopropane
NCI-C50099
Oxirane, methyl-
Oxyde de propylene (French)
Propane, epoxy-
Propene oxide
Propylene epoxide
Propylene oxide
Propylene oxide (DOT:OSHA)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 20 mg/24H moderate85JCAE -,768,1986
skin /rabbit 415 mg open irritation test moderateUCDS** 12/13/1963
skin /rabbit 50 mg/6M severeAMIHAB 13,228,1956

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1850 µg/LMUREAV 67,101,1979
Cytogenetic Analysisliver/rat25 µg/LMUREAV 153,57,1985
Cytogenetic Analysisintraperitoneal/mouse349 mg/kgMUREAV 288,223,1993
Cytogenetic Analysisovary/hamster160 mg/LSCIEAS 236,933,1987
DNA adductlymphocyte/mammal (species unspecified)100 mmol/tubeCBINA8 67,275,1988
DNA adductinhalation/rat600 mg/kg/4W- intermittentCRNGDP 21,2011,2000
DNA adductinhalation/Drosophila melanogaster2 ppm/24HMUREAV 529,95,2003
DNA adductinhalation/rat5 ppm/3D- intermittentCRNGDP 24,1233,2003
DNA Damageother cell types/mouse1.25 mmol/LMUREAV 715,25,2011
DNA Damageleukocyte/human80 µmol/L/2HMUREAV 747,1,2012
DNA Damageleukocyte/human100 µmol/L/24HMUREAV 747,1,2012
DNA Damageother cell types/human1000 µmol/L/2HMUREAV 747,1,2012
DNA Damageother cell types/human800 µmol/L/24HMUREAV 747,1,2012
DNA Damageinhalation/rat25 ppm/3D- intermittentTXAPA9 191,245,2003
DNA Damagelymphocyte/mammal (species unspecified)75 mmol/LCBINA8 9,97,1974
DNA Damageliver/rat30 µmol/LSinJF# 26OCT1982
DNA Damageintraperitoneal/mouse200 mg/kgMUREAV 467,83,2000
DNA Damagesperm/salmon5 mLABBIA4 97,80,1962
DNA Damagetestis/other fish5 gmABBIA4 97,80,1962
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
DNA Damage/Other microorganisms1 mmol/LMUREAV 368,235,1996
Dominant Lethal Testinhalation/rat300 ppm/5D- intermittentMUREAV 117,337,1983
gene conversion and mitotic recombination/Saccharomyes cerevisiae25 mmol/LMUREAV 250,229,1991
heritable translocation testparenteral/Drosophila melanogaster10 ppbEMMUEG 23,208,1994
micronucleus testintraperitoneal/mouse600 mg/kg/24HMUREAV 67,101,1979
mutation in mammalian somatic cellslymphocyte/mouse400 µg/LSCIEAS 236,933,1987
mutation in microorganisms/Neurospora crassa500 mmol/L (-enzymatic activation step)GENTAE 40,890,1955
mutation in microorganisms/Saccharomyes cerevisiae50 mmol/L (-enzymatic activation step)MUREAV 250,229,1991
mutation in microorganisms/Escherichia coli700 µg/plate (+/-enzymatic activation step)MUREAV 67,101,1979
mutation in microorganisms/Schizosaccharomyces pombe183 mmol/L (-enzymatic activation step)ADWMAX -,193,1962
mutation in microorganisms/Salmonella typhimurium350 µg/plate (+enzymatic activation step)ABCHA6 47,2461,1983
mutation in microorganisms/Salmonella typhimurium700 µg/plate (-enzymatic activation step)MUREAV 67,101,1979
mutation in microorganisms/Klebsiella pneumoniae500 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Other microorganisms25 mmol/L (-enzymatic activation step)MUREAV 73,1,1980
mutation in microorganisms/Other microorganisms5 mmol/plate (-enzymatic activation step)EMMUEG 23,274,1994
mutation in microorganisms/Salmonella typhimurium100 mg/L/2H (-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium1000 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium50 µg/plate/72H (-enzymatic activation step)TOXID9 228,66,2006
other mutation test systems/Salmonella typhimurium1 pphENMUDM 9,171,1987
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster645 ppm/24H-continuousMUREAV 117,337,1983
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster1 ppbEMMUEG 23,208,1994
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster10 ppbEMMUEG 23,208,1994
sister chromatid exchange/Saccharomyes cerevisiae100 mmol/LMUREAV 250,229,1991
sister chromatid exchangeovary/hamster5 mg/LSCIEAS 236,933,1987
sister chromatid exchangelung/hamster2500 µmol/LMUREAV 249,55,1991
sister chromatid exchangeintraperitoneal/mouse232 mg/kgMUREAV 288,223,1993
sister chromatid exchangelymphocyte/human25000 ppmENMUDM 7(Suppl 3),48,1985
specific locus testlymphocyte/mouse160 ppm/48H-continuousEMMUEG 17,122,1991
specific locus testinhalation/Drosophila melanogaster1500 ppmMUREAV 405,259,1998
specific locus testinhalation/Drosophila melanogaster3.9 ppm/24HMUREAV 529,95,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 500 ppm/7H (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB83-258038
inhalation/rat 500 ppm/7H (1-16D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)NTIS** PB83-258038
inhalation/rat 500 ppm/7H (15D prior to copulation/1-16D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
SWEHDO 9,94,1983
inhalation/monkey 100 ppm/7H (2Y male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOXID9 3,60,1983
intraperitoneal/rat 47 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NEZAAQ 49,168,1994
intraperitoneal/rat 1860 mg/kg (6W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NEZAAQ 49,168,1994

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 400 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JJIND8 77,573,1986
inhalation/mouse lowest published toxic concentration: 400 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTPTR* NTP-TR-267,1985
inhalation/mouse lowest published toxic concentration: 24720 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation/mouse lowest published toxic concentration: 24720 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation/rat toxic concentration: 400 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
JJIND8 77,573,1986
inhalation/rat toxic concentration: 300 ppm/6H/2.3Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
FCTOD7 26,159,1988
inhalation/rat lowest published toxic concentration: 12360 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB85-179653/AS
inhalation/rat lowest published toxic concentration: 10300 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors
NTIS** PB85-179653/AS
inhalation/rat lowest published toxic concentration: 100 ppm/7H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
TXAPA9 76,69,1984
oral/rat lowest published toxic dose: 10798 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
BJCAAI 46,924,1982
oral/rat toxic dose: 2714 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
BJCAAI 46,924,1982
subcutaneous/mouse lowest published toxic dose: 272 mg/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous/mouse toxic dose: 3640 mg/kg/91W- intermittentTumorigenic: Neoplastic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
BJCAAI 39,588,1979
subcutaneous/mouse toxic dose: 868 mg/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous/mouse toxic dose: 2912 mg/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous/mouse toxic dose: 6616 mg/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Tumors at site of application
ZHPMAT 174,383,1981
subcutaneous/rat lowest published toxic dose: 1500 mg/kg/46W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens
ANYAA9 68,750,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 2005 ppm/4HOlfaction: Other olfaction effects

Eye: Lacrimation

Gastrointestinal: Nausea or vomiting
AMIHAB 13,237,1956
inhalation/guinea pig Lowest published lethal concentration: 4000 ppm/4HEye: Iritis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 13,228,1956
inhalation/man lowest published toxic concentration: 1400 gm/m3/10MBehavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
GTPZAB 15(2),48,1971
inhalation/mouse lethal concentration (50 percent kill): 1740 ppm/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
AMIHAB 13,237,1956
inhalation/rat lethal concentration (50 percent kill): 4000 ppm/4HOlfaction: Other olfaction effects

Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 13,237,1956
intraperitoneal/mouse lethal dose (50 percent kill): 175 mg/kg85GMAT -,103,1982
intraperitoneal/rat lethal dose (50 percent kill): 150 mg/kg85GMAT -,103,1982
oral/guinea pig lethal dose (50 percent kill): 660 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GISAAA 46(7),76,1981
oral/mammal (species unspecified) lethal dose (50 percent kill): 440 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 440 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 14(11),55,1970
oral/rat lethal dose (50 percent kill): 380 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 14(11),55,1970
skin/rabbit lethal dose (50 percent kill): 1500 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 457 ppm/7H/22W- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 13,228,1956
inhalation/mouse lowest published toxic concentration: 487 ppm/6H/2W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTPTR* NTP-TR-267,1985
inhalation/mouse lowest published toxic concentration: 125 ppm/6H/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-267,1985
inhalation/mouse lowest published toxic dose: 200 ppm/6H/4W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TOXID9 -,109,2008
inhalation/rat lowest published toxic concentration: 51.6 ppm/3D- intermittentOlfaction: Other olfaction effectsTOLED5 185,203,2009
inhalation/rat lowest published toxic concentration: 50 ppm/6H/3D- intermittentBiochemical: Metabolism (intermediary): OtherNSAPCC 375(Suppl 1),88,2007
inhalation/rat lowest published toxic concentration: 100 ppm/6H/3D- intermittentOlfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Other
NSAPCC 375(Suppl 1),88,2007
inhalation/rat lowest published toxic dose: 400 ppm/6H/4W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TOXID9 -,109,2008
inhalation/rat lowest published toxic concentration: 457 ppm/7H/28W- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,228,1956
inhalation/rat lowest published toxic concentration: 1433 ppm/6H/12D- intermittentLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-267,1985
inhalation/rat lowest published toxic concentration: 25 mg/m3/4H/26W- intermittentBrain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section
GTPZAB 14(11),55,1970
inhalation/rat lowest published toxic concentration: 529 ppm/6H/4W- intermittentOlfaction: Other olfaction effectsFAATDF 27,25,1995
inhalation/rat lowest published toxic concentration: 997 ppm/6H/2W- intermittentCardiac: Changes in heart weight

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* OTS0535203
oral/rat lowest published toxic dose: 1170 mg/kg/45D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Other changes
GISAAA 46(7),76,1981

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 36,227,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 60,181,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 36,227,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,181,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 60,181,1994
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 580,91,2005
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWFEREAC 72,49646,2007
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWMUREAV 705,107,2010
TOXICOLOGY REVIEWMUREAV 678,76,2009
TOXICOLOGY REVIEWMUREAV 752,99,2013
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,204,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (240 mg/m3)DTLVS* 3,219,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (48 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 2.5 ppm (6 mg/m3);KZW 10 ppm (24 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (5 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (12 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.4 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (50 mg/m3), C2 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 5 mg/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (12 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 20 ppm (50 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 20 ppm (50 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (12 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (5 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (5 mg/m3);short term exposure limit 10 ppm (25 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2.5 ppm (6 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 6 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (12 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (240 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (240 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (240 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (240 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE OXIDE-airCarcinogen lowest feasible concentrtionNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 63550; Number of Industries 57; Total Number of Facilities 5786; Number of Occupations 67; Total Number of Employees Exposed 421140; Total Number of Female Employees Exposed 317309
National Occupational Hazard Survey 1974Hazard Code 63550; Number of Industries 78; Total Number of Facilities 9032; Number of Occupations 60; Total Number of Employees Exposed 75135

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NIOSH Analytical Method, 1994: Propylene oxide, 1612
NIOSH CURRENT INTELLIGENCE BULLETIN 51, JULY 1989
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis Studies (inhalation);some evidence:rat NTPTR* NTP-TR-267,1985
On EPA IRIS database
OSHA ANALYTICAL METHOD #88
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