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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,2-dibromo-3-chloro-

RTECS #

TX8750000

CAS #

96-12-8; 105567-86-0

Updated

April 2017

Molecular Weight

236.35

Molecular Formula

C3H5Br2Cl

Synonyms

(R/S)-1,2-Dibromo-3-chloropropane
1,2-Dibrom-3-chlor-propan (German)
1,2-Dibromo-3-chloropropane
1,2-Dibromo-3-chloropropane (DOT:OSHA)
1,2-Dibromo-3-chloropropane production-grade
1,2-Dibromo-3-cloro-propano (Italian)
1,2-Dibroom-3-chloorpropaan (Dutch)
1-Chloro-2,3-dibromopropane
3-Chloro-1,2-dibromopropane
BBC 12
DBCP
Dibromchlorpropan (German)
Dibromochloropropane
Fumagon
Fumazone
Fumazone 86
Fumazone 86E
NCI-C00500
Nemabrom
Nemafume
Nemagon
Nemagon 20
Nemagon 206
Nemagon 20G
Nemagon 90
Nemagon soil fumigant
Nemagone
Nemanax
Nemapaz
Nemaset
Nematocide
Nematox
Nemazon
OS 1897
Oxy DBCP
Propane, 1-chloro-2,3-dibromo-
RCRA waste number U066
SD 1897

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1% mildTXAPA9 3,545,1961
skin /rabbit 10 gm severeTXAPA9 3,545,1961

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat3650 µg/kg/5DTXAPA9 48,A46,1979
Cytogenetic Analysisovary/hamster50 mg/LSCIEAS 236,933,1987
Cytogenetic Analysislung/hamster200 µmol/LMUREAV 78,177,1980
DNA Damageintraperitoneal/mouse100 mg/kgMUREAV 419,13,1998
DNA Damageother cell types/rabbit300 µmol/LMUREAV 285,303,1993
DNA Damageother cell types/rabbit30 µmol/LMUREAV 285,303,1993
DNA Damageintraperitoneal/guinea pig40.2 mg/kgTXCYAC 58,133,1989
DNA Damagetestis/rat173 mg/LCBTOE2 1(3),181,1985
DNA Damageintraperitoneal/rat35 mg/kgCBTOE2 1(3),181,1985
DNA Damageintraperitoneal/rat1182 µg/kgCRTOEC 4,528,1991
DNA Damageliver/rat5 µmol/LCRNGDP 10,49,1989
DNA inhibitionHeLa cell/human10 mmol/LMUREAV 92,427,1982
DNA repair/Escherichia coli20900 µg/discBECTA6 14,8,1975
Dominant Lethal Testoral/rat50 mg/kg/5D-continuousMUREAV 77,71,1980
heritable translocation testoral/Drosophila melanogaster200 ppmENMUDM 7,349,1985
micronucleus testoral/mouse51.4 mg/kg/2D- intermittentGISAAA 12,41,1993
micronucleus testoral/rat12.68 mg/kg/4D- intermittentGISAAA 12,41,1993
micronucleus testoral/mouse20.4 mg/kg/4D- intermittentGISAAA 12,41,1993
micronucleus testoral/rat75 mg/kgMUREAV 234,129,1990
micronucleus testintraperitoneal/mouse50 mg/kgMUREAV 389,3,1997
morphological transformembryo/hamster7 mg/LCBTOE2 3,391,1987
mutation in mammalian somatic cellslymphocyte/mouse83700 µg/LSCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium100 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganisms/Salmonella typhimurium200 mg/L/2H (-enzymatic activation step)EMMUEG 44,329,2004
mutation in microorganismslymphocyte/mouse20 mg/L (+enzymatic activation step)CBTOE2 3,391,1987
mutation in microorganisms/Salmonella typhimurium10 nL/well (+enzymatic activation step)STEVA8 11,223,1979
mutation in microorganisms/Salmonella typhimurium500 ng/plate (-enzymatic activation step)ENMUDM 7(Suppl 3),15,1985
mutation in microorganisms/Bacillus subtilis1 nmol/plate (-enzymatic activation step)MSERDS 5,93,1981
other mutation test systems/Escherichia coli50 mg/LMUREAV 131,101,1984
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster17700 ppb/3H-continuousENMUDM 4,681,1982
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster100 ppm/3DHCKHDV 5(5),7,1984
sister chromatid exchangeovary/hamster10 mg/LSCIEAS 236,933,1987
sister chromatid exchangelung/hamster500 µmol/LMUREAV 78,177,1980
specific locus testintraperitoneal/mouse106 mg/kgMUREAV 174,145,1986
sperm morphologyoral/rat3650 µg/kg/5DTXAPA9 48,A46,1979
sperm morphologyoral/rabbit375 mg/kg/10W- intermittentFAATDF 6,628,1986
Unscheduled DNA Synthesisintraperitoneal/mouse100 mg/kgMUREAV 68,169,1979
Unscheduled DNA Synthesisintraperitoneal/rat150 mg/kgMUREAV 203,135,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 10 ppm/6H (4W male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 3,104,1983
inhalation/rat 1 ppm/6H (4W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)FAATDF 3,104,1983
inhalation/rabbit 1 ppm/6H (70D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
FAATDF 2,241,1982
inhalation/rabbit 10 ppm/6H (40D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)FAATDF 2,241,1982
intraperitoneal/rat 20090 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male

Reproductive: Specific developmental abnormalities: Urogenital system
CRTOEC 4,528,1991
oral/rat 200 mg/kg (1D male)Reproductive: Other effects on maleTOXID9 4,135,1984
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)BECTA6 21,483,1979
oral/rat 250 mg/kg (5D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
MUREAV 101,321,1982
oral/rat 50 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathMUREAV 77,71,1980
oral/rat 375 mg/kg (75D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
HYSAAV 36(1-3),344,1971
oral/rabbit 92657 µg/kg (10W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 6,638,1986
oral/mouse 875 mg/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** #PB85118644/AS
oral/mouse 100 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB85118644/AS
oral/mouse 100 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB85118644/AS
subcutaneous/rat 1 mg/kg (24W male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)BIREBV 31,454,1984
subcutaneous/rat 50 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ANDRDQ 23,363,1991
subcutaneous/rat 33 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)TXAPA9 71,294,1983
subcutaneous/rat 19 mg/kg (19D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TXAPA9 90,299,1987
subcutaneous/rat 40 mg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 79,54,1985
unreported route/rat 100 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GISAAA 40(6),101,1975
unreported route/rat 150 mg/kg (14-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001
unreported route/rat 150 mg/kg (16-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001
unreported route/rat 150 mg/kg (18-19D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 600 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JCROD7 98,75,1980
inhalation/mouse toxic concentration: 3 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JCROD7 98,75,1980
inhalation/mouse toxic concentration: 600 ppb/6H/76W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
EVHPAZ 47,365,1983
inhalation/mouse toxic concentration: 600 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-206,1982
inhalation/mouse toxic concentration: 3 ppm/6H/76W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-206,1982
inhalation/mouse lowest published toxic concentration: 136.8 mg/kg/76W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTIS** PB82-225632
inhalation/mouse lowest published toxic concentration: 37.08 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB82-225632
inhalation/rat lowest published toxic concentration: 18.54 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB82-225632
inhalation/rat lowest published toxic concentration: 15.45 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB82-225632
inhalation/rat toxic concentration: 600 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-206,1982
inhalation/rat toxic concentration: 3 ppm/6H/84W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-206,1982
inhalation/rat toxic concentration: 600 ppb/6H/76W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
EVHPAZ 47,365,1983
inhalation/rat toxic concentration: 3 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
BJCAAI 42,772,1980
inhalation/rat lowest published toxic concentration: 600 ppb/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
BJCAAI 42,772,1980
oral/mouse lowest published toxic dose: 49 gm/kg/47W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-28,1978
oral/rat lowest published toxic dose: 5475 mg/kg/73W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-28,1978
oral/rat toxic dose: 9280 mg/kg/64W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-28,1978
skin/mouse lowest published toxic dose: 100 gm/kg/74W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JJIND8 63,1433,1979
subcutaneous/rat lowest published toxic dose: 240 mg/kg/12W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TOLED5 31(Suppl),202,1986
subcutaneous/rat toxic dose: 240 mg/kg/12W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
TOLED5 31(Suppl),202,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 103 ppm/8HFEPRA7 15,448,1956
inhalation/rat lethal concentration (50 percent kill): 98 mg/m3/4HVCVGH* -,654,1990
intraperitoneal/guinea pig lowest published lethal dose: 40 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductTXCYAC 58,133,1989
intraperitoneal/hamster lowest published lethal dose: 161 mg/kgTXCYAC 58,133,1989
intraperitoneal/mouse lowest published toxic dose: 80.4 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductTXCYAC 58,133,1989
intraperitoneal/mouse lowest published lethal dose: 120 mg/kgTXCYAC 58,133,1989
intraperitoneal/mouse lethal dose (50 percent kill): 123 mg/kgMUREAV 68,169,1979
intraperitoneal/rat lowest published toxic dose: 40.2 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm ductTXCYAC 58,133,1989
intraperitoneal/rat lowest published lethal dose: 80.4 mg/kgTXCYAC 58,133,1989
intraperitoneal/rat lowest published toxic dose: 40 mg/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
CHIRA* 7,359,1995
oral/chicken lethal dose (50 percent kill): 60 mg/kgVCVGH* -,654,1990
oral/guinea pig lethal dose (50 percent kill): 150 mg/kgPCOC** -,797,1966
oral/mouse lethal dose (50 percent kill): 257 mg/kgGUCHAZ 6,172,1973
oral/rabbit lethal dose (50 percent kill): 180 mg/kgVCVGH* -,654,1990
oral/rat lowest published toxic dose: 100 mg/kgBrain and Coverings: Recordings from specific areas of CNSVCVGH* -,654,1990
oral/rat lethal dose (50 percent kill): 170 mg/kgTXAPA9 3,545,1961
skin/rabbit lethal dose (50 percent kill): 1400 mg/kgTXAPA9 3,545,1961
subcutaneous/rat lethal dose (50 percent kill): 100 mg/kgTXCYAC 27,287,1983
subcutaneous/rat lowest published toxic dose: 250 mg/kgKidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,881,2001
subcutaneous/rat lowest published toxic dose: 100 mg/kgKidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 59,84,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic dose: 12 ppm/7H/70D- intermittentRelated to Chronic Data: Changes in testicular weightTXAPA9 3,545,1961
inhalation/mouse lowest published toxic concentration: 5 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-206,1982
inhalation/rat lowest published toxic dose: 12 ppm/7H/70D- intermittentRelated to Chronic Data: Changes in testicular weightTXAPA9 3,545,1961
inhalation/rat lowest published toxic dose: 10 ppm/7H/70D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 3,545,1961
inhalation/rat lowest published toxic concentration: 25 ppm/6H/13W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above
NTPTR* NTP-TR-206,1982
inhalation/rat lowest published toxic concentration: 10 ppm/24H/14D- continuousLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
INHEAO 20,315,1982
intraperitoneal/rat lowest published toxic dose: 160 mg/kg/2D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Other changes
TOLED5 8,317,1981
oral/mouse lowest published toxic dose: 11940 mg/kg/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNCITR* NCI-TR-28,1978
oral/rat lowest published toxic dose: 3150 mg/kg/45D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Blood: Changes in spleen
MZUZA8 1(1),64,1970
oral/rat lowest published toxic dose: 2025 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 3,545,1961
oral/rat lowest published toxic dose: 602 mg/kg/64D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 13,804,1989
parenteral/rat lowest published toxic dose: 350 mg/kg/4D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOXID9 1,72,2001
parenteral/rat lowest published toxic dose: 350 mg/kg/4D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
REPTED 17,263,2003
parenteral/rat lowest published toxic dose: 350 mg/kg/4D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
REPTED 17,263,2003
parenteral/rat lowest published toxic dose: 400 mg/kg/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 17,263,2003
subcutaneous/rat lowest published toxic dose: 350 mg/kg/4D- intermittentEndocrine: Change in gonadotropins

Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOSCF2 76,418,2003
subcutaneous/rat lowest published toxic dose: 2400 mg/kg/12W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
INHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 175 mg/kg/1W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBIREBV 31,454,1984
subcutaneous/rat lowest published toxic dose: 912.5 mg/kg/26W- intermittentEndocrine: Change in LH

Related to Chronic Data: Changes in testicular weight
BIREBV 31,454,1984
subcutaneous/rat lowest published toxic dose: 4562 mg/kg/26W- intermittentEndocrine: Change in gonadotropins

Related to Chronic Data: Changes in prostate weight
BIREBV 31,454,1984
subcutaneous/rat lowest published toxic dose: 912.5 mg/kg/26W- intermittentRelated to Chronic Data: Changes in testicular weightBIREBV 31,454,1984
subcutaneous/rat lowest published toxic dose: 182.5 mg/kg/26W- intermittentEndocrine: AndrogenicBIREBV 31,454,1984
subcutaneous/rat lowest published toxic dose: 240 mg/kg/12W- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
INHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 540 mg/kg/9W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainINHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 1920 mg/kg/32W- intermittentTumorigenic: Tumors at site of applicationINHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 2160 mg/kg/36W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)INHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 400 mg/kg/2W- intermittentSkin and Appendages: Other: HairINHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 600 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainINHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 2400 mg/kg/12W- intermittentBlood: Luekopenia

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Changes in testicular weight
INHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 6000 mg/kg/30W- intermittentTumorigenic: Tumors at site of applicationINHEAO 27,49,1989
subcutaneous/rat lowest published toxic dose: 7200 mg/kg/36W- intermittentBlood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count
INHEAO 27,49,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,83,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 15,139,1977
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,479,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,191,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,479,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,479,1999
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWTOLED5 127,135,2002
TOXICOLOGY REVIEWTOLED5 134,17,2002
TOXICOLOGY REVIEWTOLED5 135,167,2002
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,546,2005
TOXICOLOGY REVIEWENTOX* -,793,2005
TOXICOLOGY REVIEWENTOX* -,193,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWREPTED 33,269,2012
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 783,66,2015
TOXICOLOGY REVIEWTXCYAC 307,3,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 ppm (0.01 mg/m3), carc, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.001 ppm (0.01 mg/m3), carc, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1144CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1044,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DIBROMO-3-CHLOROPROPANE-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1044NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code M2705; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 6; Total Number of Employees Exposed 176

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Sperm morphology-human
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-206,1982
On EPA IRIS database
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