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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1-chloro-1-nitro-

RTECS #

TX5075000

CAS #

600-25-9

Updated

September 2013

Molecular Weight

123.55

Molecular Formula

C3H6ClNO2

Synonyms

1-Chloro-1-nitropropane (ACGIH:OSHA)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+/-enzymatic activation step)EMMUEG 19(Suppl 21),2,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 18 gm/m3/2HLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
JIHTAB 27,95,1945
inhalation/mouse lethal concentration (50 percent kill): 66 gm/m3/3HBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
HYSAAV 34(10-12),429,1969
inhalation/rabbit Lowest published lethal concentration: 2 gm/m3/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
JIHTAB 27,95,1945
oral/mouse lethal dose (50 percent kill): 510 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
HYSAAV 34(10-12),429,1969
oral/rabbit lowest published lethal dose: 50 mg/kgVascular: Other changes

Lung, Thorax, or Respiration: Other changes
JIHTAB 27,95,1945
oral/rat lowest published lethal dose: 50 mg/kg85JCAE -,596,1986
skin/mouse Lethal dose: >5000 mL/kgHYSAAV 34,429,1969
subcutaneous/mouse lethal dose (50 percent kill): 165 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
HYSAAV 34(10-12),429,1969

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 20 ppm (100 mg/m3)DTLVS* 3,53,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (10 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (100 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (10 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (10 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (100 mg/m3), short term exposure limit 30 ppm (150 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (10 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 20 ppm (100 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (10 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (10 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 50 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (10 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 20 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 20 ppm (100 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 20 ppm (100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 20 ppm (100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 20 ppm (100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 20 ppm (100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-CHLORO-1-NITROPROPANE-air10H time-weighted average 2 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 18590; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 721
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