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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1-butoxy-2,3-epoxy-

RTECS #

TX4200000

CAS #

2426-08-6

Updated

October 2017

Molecular Weight

130.21

Molecular Formula

C7H14O2

Synonyms

2,3-Epoxypropyl butyl ether
Ageflex BGE
BGE (OSHA)
Butyl glycidyl ether
Ether, butyl 2,3-epoxypropyl
Ether, butyl glycidyl
Glycidyl butyl ether
n-Butyl glycidyl ether
n-Butyl glycidyl ether (ACGIH:OSHA)
Oxirane, (butoxymethyl)- (9CI)
TK 10408

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 91 mg mildAMIHAB 14,250,1956
eye /rabbit 750 µg/24H severe85JCAE -,774,1986
skin /rabbit 454 mg/3D mildAMIHAB 14,250,1956
skin /rabbit 20 mg/24H moderate85JCAE -,774,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
micronucleus testintraperitoneal/mouse675 mg/kgENMUDM 2,521,1980
mutation in microorganisms/Salmonella typhimurium10 mg/plate (+/-enzymatic activation step)MUREAV 66,367,1979
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980
other mutation test systems/Escherichia coli1 mmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster2500 µmol/LMUREAV 249,55,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
skin/mouse 36 gm/kg (24D male)Reproductive: Effects on embryo or fetus: Fetal deathMUREAV 124,225,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): 5500 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 776 mg/L/30MIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 185.3 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, monocyte Inhibitor Concentration Low: 2500 mg/L/2HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1233,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): >2000 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 218.5 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,281,2010
In Vitro/jrdInhibitor Concentration (50 percent kill): 4.22 mg/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,626,2014
inhalation/mouse lethal concentration (50 percent kill): 260 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(8),91,1986
inhalation/rat lethal concentration (50 percent kill): 1030 ppm/8HEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 14,250,1956
intraperitoneal/mouse lethal dose (50 percent kill): 700 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
intraperitoneal/rat lethal dose (50 percent kill): 1140 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral/mouse lethal dose (50 percent kill): 1530 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral/rat lethal dose (50 percent kill): 1660 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(8),91,1986
skin/rabbit lethal dose (50 percent kill): 2520 µL/kgAIHAAP 23,95,1962
skin/rat lethal dose (50 percent kill): >2150 mg/kgTSCAT* OTS0515483

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 3 ppm (skin, sen)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (270 mg/m3)DTLVS* 3,33,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (133 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 3 ppm (16.2 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 6 ppm (30 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 25 ppm (140 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 25 ppm (135 mg/m3), C3 Carcinogen, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 6 ppm (30 mg/m3), sen, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (135 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (135 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (133 mg/m3), sen, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (133 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (50 mg/m3);short term exposure limit 15 ppm (80 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 25 ppm (135 mg/m3), KZG-week 50 ppm (270 mg/m3), skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 135 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (270 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (270 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (270 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (270 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL GLYCIDYL ETHER-airceiling concentration 5.6 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 14720; Number of Industries 56; Total Number of Facilities 2593; Number of Occupations 57; Total Number of Employees Exposed 60217; Total Number of Female Employees Exposed 14929
National Occupational Hazard Survey 1974Hazard Code 14720; Number of Industries 37; Total Number of Facilities 1596; Number of Occupations 45; Total Number of Employees Exposed 19839

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8718;8EHQ-0892-9000
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: n-Butyl glycidyl ether, 1616
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
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