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Registry of Toxic Effects of Chemical Substances (RTECS)

Plumbane, tetramethyl-

RTECS #

TP4725000

CAS #

75-74-1

Updated

October 2017

Molecular Weight

267.35

Molecular Formula

C4H12Pb

Synonyms

Lead, tetramethyl-
Piombo tetra-metile (Italian)
Tetramethyl lead
Tetramethyl lead (ACGIH:OSHA)
Tetramethylolovo (Czech)
Tetramethylplumbane
TML

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 112 mg/kg (9-11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 21,265,1972
oral/rat 80 mg/kg (9-11D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 21,265,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 8500 mg/m3/30M85JCAE -,1258,1986
inhalation/rat Lethal concentration: >9840 mg/m3/1HBJIMAG 18,277,1961
intraperitoneal/rat lethal dose (50 percent kill): 90 mg/kgMELAAD 54,486,1963
intravenous/rabbit lowest published lethal dose: 90 mg/kgEye: Other eye effects

Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPETAB 38,161,1930
intravenous/rat lethal dose (50 percent kill): 88 mg/kgMELAAD 54,486,1963
oral/guinea pig lethal dose (50 percent kill): 109 mg/kgYAKUD5 22,455,1980
oral/rabbit lowest published lethal dose: 24 mg/kgSAIGBL 15,3,1973
oral/rat lethal dose (50 percent kill): 105 mg/kgMELAAD 54,486,1963
parenteral/rat lethal dose (50 percent kill): 105 mg/kgAOHYA3 3,226,1961
skin/rabbit lowest published lethal dose: 3391 mg/kgSAIGBL 15,3,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 900 mg/m3/1H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Irritability

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0533656-1
intravenous/monkey lowest published toxic dose: 42 mg/kg/7D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOLED5 2,187,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.15 mg(Pb)/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW85DHAX Pb,255,1972
TOXICOLOGY REVIEWMUREAV 770,119,I2

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.15 mg(Pb)/m3 (skin)DTLVS* 3,253,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 mg(Pb)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.007 ppm (0.05 mg(Pb)/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.075 mg(Pb)/m3, short term exposure limit 0.23 mg(Pb)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.15 mg(Pb)/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.05 mg(Pb)/m3, skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.075 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3;short term exposure limit 0.5 mg(Pb)/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.15 mg(Pb)/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,15 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg(Pb)/m3;short term exposure limit 0.2 mg(Pb)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Pb)/m3, KZG-week 0.1 mg(Pb)/m3, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.07 mg/m3, JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.07 mg/m3, Skin, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.15 mg(Pb)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.075 mg(Pb)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.075 mg(Pb)/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.15 mg(Pb)/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYLLEAD-air10H time-weighted average 0.075 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 71860; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 7

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetramethyl lead (as Pb), 2534
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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