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Registry of Toxic Effects of Chemical Substances (RTECS)

Piperazine, dihydrochloride

RTECS #

TL4025000

CAS #

142-64-3

Updated

September 2013

Molecular Weight

159.08

Molecular Formula

C4H10N2·2ClH

Synonyms

Diethylenediamine dihydrochloride
Dihydro Pip Wormer
Dihydrochloride salt of diethylenediamine
Dowzene DHC
Piperazine dihydrochloride (ACGIH)
Piperazine hydrochloride
Piperazine wormer premix

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1970 mg/kgLung, Thorax, or Respiration: Respiratory stimulationJJPAAZ 17,475,1967
oral/rat lethal dose (50 percent kill): 4900 mg/kgGUCHAZ 6,416,1973
subcutaneous/mouse lethal dose (50 percent kill): 2030 mg/kgARZNAD 4,649,1954

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.03 ppm (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.3 mg(C4H10N2)/m3);short term exposure limit 0.3 ppm (1 mg/m3), Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)skinCFRGBR 29,1926.55,1994

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PIPERAZINE-air10H time-weighted average 5.0 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80559; Number of Industries 1; Total Number of Facilities 163; Number of Occupations 12; Total Number of Employees Exposed 5730
National Occupational Hazard Survey 1974Hazard Code 80559; Number of Industries 1; Total Number of Facilities 68; Number of Occupations 5; Total Number of Employees Exposed 1284

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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