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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorous acid, trimethyl ester

RTECS #

TH1400000

CAS #

121-45-9

Updated

September 2013

Molecular Weight

124.09

Molecular Formula

C3H9O3P

Synonyms

Fosforyn trojmetylowy (Czech)
Trimethoxyfosfin (Czech)
Trimethoxyphosphine
Trimethyl phosphite
Trimethyl phosphite (ACGIH)
Trimethylfosfit (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /mammal (species unspecified) 100 mg mildMEPAAX 29,393,1978
eye /rabbit 0.1 mL mildHPV416 -,-,2005
skin /mammal (species unspecified) 500 mg mildMEPAAX 29,393,1978
skin /rabbit 500 mg severe34ZIAG -,609,1969
skin /rabbit 0.5 mL mildHPV416 -,-,2005

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellsother cell types/mouse2.7 mL/L (+/-enzymatic activation step)HPV416 ,,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1640 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 72,119,1984
oral/rat 1640 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis
TXAPA9 72,119,1984
oral/rat 1640 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
HPV416 -,-,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 51500 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV416 -,-,2005
oral/rat lowest published toxic dose: 103000 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV416 -,-,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lethal concentration: >32700 mg/m3/6HEye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity)
NTIS** OTS0537047
inhalation/mouse Lowest published lethal concentration: 32700 mg/m3/6HEye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity)
NTIS** OTS0537047
inhalation/rat Lowest published lethal concentration: 32700 mg/m3/6HEye: Lacrimation

Eye: Ptosis

Behavioral: Somnolence (general depressed activity)
NTIS** OTS0537047
inhalation/rat lethal concentration (50 percent kill): 182000 mg/m3/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV416 -,-,2005
inhalation/rat lethal concentration (50 percent kill): >9000 ppm/4HHPV416 -,-,2005
intraperitoneal/mouse lethal dose (50 percent kill): 4180 mg/kgENVRAL 9,1,1975
oral/mouse lethal dose (50 percent kill): 4280 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0540442
oral/rat lethal dose (50 percent kill): 1350 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach
HPV416 -,-,2005
oral/rat lethal dose (50 percent kill): 1500 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes

Blood: Changes in spleen
HPV416 -,-,2005
oral/rat lethal dose (50 percent kill): 1600 mg/kgALBRW* #OPB-3,1984
skin/rabbit lethal dose (50 percent kill): 933.8 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV416 -,-,2005
skin/rabbit lethal dose (50 percent kill): 2600 mg/kgAIHAAP 34,286,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/7.5H/8W- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Skin and Appendages: Other: Hair
AIHAAP 34,286,1973
inhalation/rat lowest published toxic concentration: 292 ppm/4W- intermittentEye: Corneal damage

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV416 -,-,2005
inhalation/rat lowest published toxic concentration: 50 ppm/28D- intermittentEye: Corneal damageHPV416 -,-,2005
inhalation/rat lowest published toxic concentration: 500 ppm/8W- intermittentLung, Thorax, or Respiration: Emphysema

Skin: After systemic exposure: Dermatitis, irritative
HPV416 -,-,2005
oral/rat lowest published toxic dose: 689 mg/kgOlfaction: Other olfaction effects

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Other changes
NTIS** OTS0540442
oral/rat lowest published toxic dose: 3444 mg/kg/21D- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV416 -,-,2005
oral/rat lowest published toxic dose: 14400 mg/kg/90D- intermittentLiver: Fatty liver degeneration

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV416 -,-,2005
skin/rabbit lowest published toxic dose: 6300 mg/kg/21D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV416 -,-,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (10 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (2.6 mg/m3);KZW 1 ppm (5.2 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (10 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.6 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (2.6 mg/m3), short term exposure limit 10 ppm (51 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.6 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (10 mg/m3);short term exposure limit 5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (10 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Cd)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (10 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (10 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (10 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL PHOSPHITE-air10H time-weighted average 2 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84215; Number of Industries 2; Total Number of Facilities 55; Number of Occupations 18; Total Number of Employees Exposed 14190; Total Number of Female Employees Exposed 6312
National Occupational Hazard Survey 1974Hazard Code 84215; Number of Industries 5; Total Number of Facilities 260; Number of Occupations 7; Total Number of Employees Exposed 1891

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8977;8EHQ-0892-8988
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9122
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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