Phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester

RTECS #

TE4550000

CAS #

563-12-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

384.49

Molecular Formula

C₉H₂₂O₄P₂S₄

Synonyms

Bis(S-(diethoxyphosphinothioyl)mercapto)methane
Diethion
Embathion
ENT 24,105
Ethanox
Ethiol 100
Ethion
Ethion (ACGIH)
Ethodan
Ethopaz
Ethyl methylene phosphorodithioate
FMC-1240
Fosfatox E
Fosfono 50
Hylemox
KWIT
Methyleen-S,S'-bis(O,O-diethyl-dithiofosfaat) (Dutch)
Methylene-S,S'-bis(O,O-diaethyl-dithiophosphat) (German)
NIA 1240
Niagara 1240
Nialate
O,O,O',O'-Tetraaethyl-bis(dithiophosphat) (German)
O,O,O',O'-Tetraethyl S,S'-methylene di(phosphorodithioate)
O,O,O',O'-Tetraethyl S,S'-methylenebisphosphordithioate
O,O,O',O'-Tetraethyl-S,S'-methylenebisphosphorodithioate
Phosphorodithioic acid, O,O-diethyl ester, S,S-diester with methanedithiol
Phosphotox E
Rhodocide
Rodocid
RP 8167
S,S'-Methylen-bis(O,O-diaethyl-dithiophosphat) (German)
S,S'-Methylene O,O,O',O'-tetraethyl phosphorodithioate
Tafethion
Tetraethyl S,S'-methylene bis(phosphorothiolothionate)
Vegfru fosmite

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 864 mg/m³		FMCHA2 -,C128,1991
intraperitoneal/mouse	lethal dose (50 percent kill): 35 mg/kg		PSEBAA 129,699,1968
intraperitoneal/rat	lethal dose (50 percent kill): 26 mg/kg		PSEBAA 129,699,1968
oral/guinea pig	lethal dose (50 percent kill): 40 mg/kg		85DPAN -,-,1971/1976
oral/human	lowest published toxic dose: 100 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 22,286,1972
oral/infant	lowest published toxic dose: 15700 µg/kg	Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature increase	TXMDAX 63,71,1967
oral/mouse	lethal dose (50 percent kill): 40 mg/kg		85DPAN -,-,1971/1976
oral/rat	lethal dose (50 percent kill): 13 mg/kg		PHJOAV 185,361,1960
oral/wild bird	lethal dose (50 percent kill): 45 mg/kg		TXAPA9 21,315,1972
skin/guinea pig	lethal dose (50 percent kill): 915 mg/kg		85DPAN -,-,1971/1976
skin/rat	lethal dose (50 percent kill): 62 mg/kg		TXAPA9 14,515,1969
unreported route/rat	lethal dose (50 percent kill): 55 mg/kg		30ZDA9 -,367,1971

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 675 mg/kg/90D- continuous	Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 8,173,1988
oral/Dog	lowest published toxic dose: 182 mg/kg/1Y- continuous	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOXID9 8,173,1988

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		MUREAV 721,27,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,117,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.4 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.4 mg/m³;KZW 0.8 mg/m³, skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 mg/m³ (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.4 mg/m³, skin, MAY2011
Occupational Exposure Limit-FRANCE	VME 0.4 mg/m³, Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.4 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.4 mg/m³, skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.4 mg/m³ (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.4 mg/m³, skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,4 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.4 mg/m³, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.4 mg/m³, Skin, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHION-air	10H time-weighted average 0.4 mg/m³ (Sk)	NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974	Hazard Code 84542; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108024)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health