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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-diethyl S-(ethylthio)methyl ester

RTECS #

TD9450000

CAS #

298-02-2

Updated

December 2016

Molecular Weight

260.39

Molecular Formula

C7H17O2PS3

Synonyms

AC 3911
Agrimet
American cyanamid 3,911
Dithiophosphate de O,O-diethyle et d'ethylthiomethyle (French)
EI3911
ENT 24,042
Experimental insecticide 3911
Foraat (Dutch)
Geomet
Granutox
L 11/6
Methanethiol, (ethylthio)-, S-ester with O,O-diethyl phosphorodithioate
O,O-Diaethyl-S-(aethylthio-methyl)-dithiophosphat (German)
O,O-Diethyl ethylthiomethyl phosphorodithioate
O,O-Diethyl S-(ethylthio)methyl phosphorodithioate
O,O-Diethyl S-ethylmercaptomethyl dithiophosphonate
O,O-Diethyl S-ethylthiomethyl dithiophosphonate
O,O-Diethyl S-ethylthiomethyl thiothionophosphate
O,O-Diethyl-S-(ethylthio-methyl)-dithiofosfaat (Dutch)
O,O-Dietil-S-(etiltio-metil)-ditiofosfato (Italian)
Phorat (German)
Phorate
Phorate (ACGIH)
Phorate-10G
Rampart
RCRA waste number P094
Thimenox
Thimet
Timet
Vegfru
Vergfru foratox
VUAgT 182

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 1%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat180 µg/kgNULSAK 33,14,1990
Cytogenetic Analysisovary/hamster40 mg/LMUREAV 188,241,1987
Cytogenetic Analysisembryo/human50 µmol/L/72HMUREAV 744,125,2012
DNA Damageoral/rat12.88 mg/kg/14DTXAPA9 259,54,2012
micronucleus testintraperitoneal/rat750 µg/kg/5D-continuousMUREAV 188,45,1987
micronucleus testintraperitoneal/mouse750 µg/kgMUREAV 155,131,1985
sister chromatid exchangelymphocyte/human2 mg/LMUREAV 102,89,1982
sister chromatid exchangeother cell types/rat50 mg/LMUREAV 188,311,1987
sister chromatid exchangeovary/hamster40 mg/LMUREAV 188,311,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/gerbil 2500 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
IJEBA6 18,1001,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, embryonic cells Inhibitor Concentration Low: 100 µmol/L/72HIn Vitro Toxicity Studies: Other assaysFCTOD7 49,1787,2011
In Vitro/Human, embryonic cells Inhibitor Concentration Low: 500 µmol/L/72HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 49,1787,2011
inhalation/rat lethal concentration (50 percent kill): 11 mg/m3/1HNTIS** PB277-077
intraperitoneal/gerbil lethal dose (50 percent kill): 1866 µg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Gastrointestinal: Hypermotility, diarrhea
JAMPA2 28,234,1981
intraperitoneal/mouse lethal dose (50 percent kill): 2100 µg/kgAEPPAE 236,202,1959
intraperitoneal/rat lethal dose (50 percent kill): 1980 µg/kgAEPPAE 236,202,1959
intravenous/rat lethal dose (50 percent kill): 1200 µg/kgNTIS** PB277-077
oral/duck lethal dose (50 percent kill): 600 µg/kgDOEAAH 35,25,1979
oral/mouse lethal dose (50 percent kill): 2250 µg/kgAEPPAE 236,202,1959
oral/quail lethal dose (50 percent kill): 7 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral/rat lethal dose (50 percent kill): 1 mg/kgDOEAAH 35,25,1979
oral/wild bird lethal dose (50 percent kill): 1 mg/kgTXAPA9 21,315,1972
skin/duck lethal dose (50 percent kill): 203 mg/kgTXAPA9 47,451,1979
skin/guinea pig lethal dose (50 percent kill): 20 mg/kgPCOC** -,895,1966
skin/rabbit lethal dose (50 percent kill): 3.1 mg/kgUSXXAM #6193990
skin/rat lethal dose (50 percent kill): 2.5 mg/kgUSXXAM #6193990
skin/rat lethal dose (50 percent kill): 2500 µg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2.576 mg/kg/14D- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
TXAPA9 259,54,2012

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 46,1,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 73,6867,2008
TOXICOLOGY REVIEWFEREAC 73,53732,2008
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWTXAPA9 258,309,2012
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,142,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.05 mg/m3;KZW 0.1 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.05 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 mg/m3;short term exposure limit 0.2 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 ppm, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3; short term exposure limit 0,2 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 mg/m3;short term exposure limit 0.2 mg/m3, skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHORATE-air10H time-weighted average 0.05 mg/m3;short term exposure limit 0.2 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
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