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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester

RTECS #

TD9275000

CAS #

298-04-4

Updated

December 2016

Molecular Weight

274.42

Molecular Formula

C8H19O2PS3

Synonyms

BAY 19639
Bayer 19639
Disulfoton
Disulfoton (ACGIH)
Di-syston
Dithiodemeton
Dithiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) (French)
Dithiosystox
Dution
Ekatin TD
ENT 23,437
Ethyl thiometon
Ethylthiometon B
Frumin AL
Frumin G
Glebofos
M-74
M-74 (Pesticide)
O,O-Diaethyl-S-(2-aethylthio-aethyl)-dithiophosphat (German)
O,O-Diaethyl-S-(3-thia-pentyl)-dithiophosphat (German)
O,O-Diethyl 2-ethylthioethyl phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) phosphorodithioate
O,O-Diethyl S-(2-eththioethyl) thiothionophosphate
O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate
O,O-Diethyl S-2-(ethylthio)ethyl phosphorodithioate
O,O-Diethyl-S-(2-ethylthio-ethyl)-dithiofosfaat (Dutch)
O,O-Dietil-S-(2-etiltio-etil)-ditiofosfato (Italian)
O,O-Ethyl S-2(ethylthio)ethyl phosphorodithioate
Phosphorodithionic acid, S-2-(ethylthio)ethyl-O,O-diethyl ester
RCRA waste number P039
S-(2-(Ethylthio)ethyl)phosphorothionate
S-2-(Ethylthio)ethyl O,O-diethyl ester of phosphorodithioic acid
Solvirex
Thiodemeton
Vuagt 1-4
Vuagt 1964

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslymphocyte/mouse40 mg/LNTIS** PB84-138973
mutation in microorganisms/Salmonella typhimurium5720 µg/plate (+enzymatic activation step)MUREAV 28,405,1975
mutation in microorganisms/Salmonella typhimurium5 mg/plate (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Escherichia coli5720 µg/plate (-enzymatic activation step)MUREAV 28,405,1975
Unscheduled DNA Synthesisfibroblast/human1 gm/LNTIS** PB80-133226

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 10 mg/m3/4HBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 4(9),21,1960
inhalation/rat lethal concentration (50 percent kill): 200 mg/m385GYAV -,25,1971
inhalation/rat lethal concentration (50 percent kill): 180 ppb/1HENTOX* -,85,2005
inhalation/rat lethal concentration (50 percent kill): 90 mg/m3/1HENTOX* -,85,2005
intraperitoneal/guinea pig lethal dose (50 percent kill): 7 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
AMIHAB 17,192,1958
intraperitoneal/mouse lethal dose (50 percent kill): 5500 µg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
AMIHAB 17,192,1958
intraperitoneal/rat lethal dose (50 percent kill): 2 mg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
AMIHAB 17,192,1958
intravenous/rat lethal dose (50 percent kill): 5500 µg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
13ZGAF -,206,1962
oral/Dog lethal dose (50 percent kill): 5 mg/kgPEMNDP 9,318,1991
oral/duck lethal dose (50 percent kill): 6500 µg/kgDOEAAH 35,25,1979
oral/guinea pig lethal dose (50 percent kill): 10800 µg/kgPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume increased
AMIHAB 17,192,1958
oral/mouse lethal dose (50 percent kill): 4800 µg/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 4(9),21,1960
oral/quail lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral/rat lethal dose (50 percent kill): 2600 µg/kgYKYUA6 37,717,1986
oral/wild bird lethal dose (50 percent kill): 2400 µg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 800 µg/kgBehavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
JJTOEX 8,69,1995
skin/mouse lethal dose (50 percent kill): 15600 µg/kgYKYUA6 37,717,1986
skin/rabbit lowest published lethal dose: 5 mg/kgGTPZAB 2(5),7,1958
skin/rat lethal dose (50 percent kill): 3.6 mg/kgENTOX* -,85,2005
unreported route/chicken lethal dose (50 percent kill): 28 mg/kgFMCHA2 -,C113,1991
unreported route/mouse lethal dose (50 percent kill): 4600 µg/kgGTPZAB 7(5),38,1963
unreported route/rat lethal dose (50 percent kill): 2500 µg/kg30ZDA9 -,369,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 140 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 65,457,1982
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/60D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 17,192,1958
intraperitoneal/rat lowest published toxic dose: 60 mg/kg/30D- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
FAATDF 20,163,1993
intraperitoneal/rat lowest published toxic dose: 28 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 40,47,1988
oral/Dog lowest published toxic dose: 36500 µg/kg/1Y- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 42,154,1998
oral/rat lowest published toxic dose: 5460 µg/kg/13W- continuousBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FAATDF 35,101,1997
oral/rat lowest published toxic dose: 352 mg/kg/20W- continuousBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other
ANYAA9 160,378,1969
oral/rat lowest published toxic dose: 61 mg/kg/9W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGTPZAB 4(9),21,1960
unreported route/rat lowest published toxic dose: 28 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changesHBPTO* 2,1026,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWMZUZA8 (8),90,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWENTOX* -,85,2005
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWFEREAC 73,80317,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFEREAC 74,46689,2009
TOXICOLOGY REVIEWNBREV* 9,479,1985
TOXICOLOGY REVIEWMUREAV 760,1,2014
TOXICOLOGY REVIEWMUREAV 752,67,2013
TOXICOLOGY REVIEWNRTXDN 39,158,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,115,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DISULFOTON-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code T0249; Number of Industries 2; Total Number of Facilities 92; Number of Occupations 2; Total Number of Employees Exposed 165

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264347)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
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