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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid, tri-o-tolyl ester

RTECS #

TD0350000

CAS #

78-30-8

Updated

April 2017

Molecular Weight

368.39

Molecular Formula

C21H21O4P

Synonyms

o-Cresyl phosphate
o-Tolyl phosphate
o-Trikresylphosphate (German)
Phosflex 179C
Phosphoric acid, tri-o-cresyl ester
Phosphoric acid, tris(2-methylphenyl) ester
TOCP
TOFK
TOTP
Tri 2-methylphenyl phosphate
Tri-2-tolyl phosphate
Tri-o-cresyl phosphate
Tri-o-cresyl-phosphate
Triorthocresyl phosphate
Triorthocresyl phosphate (ACGIH:OSHA)
Tri-o-tolyl phosphate
Tri-o-totyl phosphate
Tris(o-cresyl)-phosphate
Tris(o-methylphenyl)phosphate
Tris(o-tolyl)-phosphate
Trojkrezylu fosforan (Polish)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat500 mg/kg/10D-continuousCRNGDP 14,2039,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1500 mg/kg (10D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 89,64,1987
oral/rat 2100 mg/kg (14D pregnant)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXAPA9 107,35,1991
oral/rat 450 mg/kg (3D male)Reproductive: Other effects on maleTXAPA9 89,64,1987
oral/rat 3150 mg/kg (21D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 89,64,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, ovary Inhibitor Concentration (20 percent kill): 9.4 µmol/L/24HEndocrine: EstrogenicTXCYAC 314,76,2013
In Vitro/Hamster, ovary Inhibitor Concentration (20 percent kill): 11 µmol/L/24HEndocrine: Other changesTXCYAC 314,76,2013
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 0.2 mmol/L/24HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 310,92,2013
intramuscular/rabbit lowest published lethal dose: 135 mg/kgAEPPAE 171,439,1933
intraperitoneal/chicken lethal dose (50 percent kill): 500 mg/kgEQSFAP 3,173,1974
intraperitoneal/mouse lethal dose (50 percent kill): 1960 mg/kgTXAPA9 2,495,1960
intraperitoneal/rabbit lowest published lethal dose: 100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
AEPPAE 168,473,1932
intraperitoneal/rat lethal dose (50 percent kill): 2500 mg/kgAPCRAW 4,117,1961
intraperitoneal/rat lowest published toxic dose: 10 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 179,119,2002
intraperitoneal/rat lowest published toxic dose: 100 mg/kgLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 72,315,2003
intraperitoneal/rat lowest published toxic dose: 100 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Metabolism (intermediary): Lipids including transport
JTEHF8 67,583,2004
intratracheal/chicken lowest published toxic dose: 750 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia
TOLED5 210,276,2012
intravenous/chicken lowest published toxic dose: 40 mg/kgBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 143,65,2003
intravenous/rabbit lowest published lethal dose: 100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Other changes in urine composition
AEPPAE 168,473,1932
oral/chicken lowest published toxic dose: 800 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral/chicken lowest published toxic dose: 1600 mg/kgBrain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 136,143,2002
oral/chicken lowest published toxic dose: 1600 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Ataxia
TOLED5 136,143,2002
oral/chicken lethal dose (50 percent kill): 500 mg/kgEQSFAP 3,173,1974
oral/chicken lowest published toxic dose: 750 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
JPETAB 239,597,1986
oral/chicken lowest published toxic dose: 360 mg/kgSpinal Cord: Demyelination

Spinal Cord: Other degenerative changes
HBPTO* 2,989,2001
oral/chicken lowest published toxic dose: 200 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
NRTXDN 9,539,1988
oral/chicken lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
NRTXDN 6,79,1985
oral/chicken lowest published toxic dose: 200 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Muscle weakness

Biochemical: Metabolism (intermediary): Other
ENVRAL 60,290,1993
oral/chicken lowest published toxic dose: 50 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)
TAEHC* 110IV,122,1990
oral/chicken lowest published toxic dose: 750 mg/kgBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia
TXCYAC 223,127,2006
oral/chicken lowest published toxic dose: 750 mg/kgBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXCYAC 239,45,2007
oral/chicken lowest published toxic dose: 750 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 252,56,2008
oral/chicken lowest published toxic dose: 750 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 258,94,2009
oral/chicken lowest published toxic dose: 500 mg/kgBehavioral: Ataxia

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
HETOEA 27,247,2008
oral/chicken lowest published toxic dose: 750 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheathTXCYAC 262,258,2009
oral/chicken lowest published toxic dose: 500 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 192,238,2010
oral/chicken lowest published toxic dose: 500 mg/kgSpinal Cord: Other degenerative changes

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 302,88,2012
oral/domestic bird lowest published toxic dose: 375 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 191,25,2003
oral/mammal (species unspecified) lethal dose (50 percent kill): 400 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 900 mg/kgGastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Behavioral: Muscle weakness
TXAPA9 7,227,1965
oral/rabbit lowest published lethal dose: 100 mg/kgBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis
AEPPAE 168,473,1932
oral/rat lethal dose (50 percent kill): 1160 mg/kgTOXID9 4,55,1984
oral/rat lowest published toxic dose: 840 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TAEHC* 110IV,122,1990
skin/cat lethal dose (50 percent kill): 1500 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea
NTOTDY 5,431,1983
skin/rabbit lethal dose (50 percent kill): >3700 mg/kgTXAPA9 41,291,1977
subcutaneous/cat lowest published lethal dose: 185 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
JHHBAI 52,39,1933
subcutaneous/chicken lowest published toxic dose: 60 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia
TOLED5 210,276,2012
subcutaneous/Dog lowest published lethal dose: 100 mg/kgBehavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis
AEPPAE 168,473,1932
subcutaneous/guinea pig lowest published lethal dose: 300 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Musculoskeletal: Other changes
AEPPAE 168,473,1932
subcutaneous/monkey lowest published lethal dose: 1 gm/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea
AEPPAE 165,84,1972
subcutaneous/mouse lowest published lethal dose: 12500 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
EDWU** -,-,1937
subcutaneous/mouse lowest published toxic dose: 10 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
TXAPA9 255,214,2011
subcutaneous/rabbit lowest published lethal dose: 100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Other changes in urine composition
AEPPAE 168,473,1932
unreported route/chicken lowest published toxic dose: 500 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia
TOXID9 78,227,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 7 gm/kg/7D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases
JEPOEC 17,69,1998
intraperitoneal/rat lowest published toxic dose: 2800 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
DTESD7 11,495,1983
oral/chicken lowest published toxic dose: 1800 mg/kg/18D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
TOLED5 37,279,1987
oral/chicken lowest published toxic dose: 1050 mg/kg/14D- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
TOXID9 42,126,1998
oral/chicken lowest published toxic dose: 450 mg/kg/90D- continuousSpinal Cord: Other degenerative changes

Behavioral: Ataxia
NTIS** OTS0518529
oral/domestic animal lowest published toxic dose: 900 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 69,417,1983
oral/duck lowest published toxic dose: 3 gm/kg/30D- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Ataxia
JTEHD6 14,789,1984
oral/mouse lowest published toxic dose: 4725 mg/kg/21D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 18(Suppl 1),4,1983
oral/mouse lowest published toxic dose: 60750 mg/kg/39W- intermittentSpinal Cord: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia
TXAPA9 79,83,1985
oral/mouse lowest published toxic dose: 1400 mg/kg/14D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductTOLED5 211,54,2012
oral/rabbit lowest published toxic dose: 1500 mg/kg/3D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Autonomic Nervous System: Other (direct) parasympathomimetic
TXAPA9 41,291,1977
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentAutonomic Nervous System: Other (direct) parasympathomimetic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 1575 mg/kg/63D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 1600 mg/kg/2D- intermittentBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 18900 mg/kg/9W- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
TOLED5 13,29,1982
oral/rat lowest published toxic dose: 600 mg/kg/3D- intermittentBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 89,49,1987
oral/rat lowest published toxic dose: 3150 mg/kg/63D- intermittentBehavioral: Food intake (animal)

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TXAPA9 89,49,1987
oral/rat lowest published toxic dose: 4725 mg/kg/63D- intermittentRelated to Chronic Data: Changes in testicular weightTXAPA9 89,49,1987
oral/rat lowest published toxic dose: 1575 mg/kg/63D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 89,49,1987
oral/rat lowest published toxic dose: 630 mg/kg/63D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesTXAPA9 89,49,1987
oral/rat lowest published toxic dose: 4200 mg/kg/63D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 72,305,2003
oral/rat lowest published toxic dose: 1050 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changesTOXID9 72,305,2003
oral/rat lowest published toxic dose: 4200 mg/kg/48D- intermittentBlood: Other changesTOXID9 66,316,2002
oral/rat lowest published toxic dose: 8400 mg/kg/48D- intermittentLiver: Liver function tests impairedTOXID9 66,316,2002
oral/rat lowest published toxic dose: 2100 mg/kg/48D- intermittentLiver: Other changesTOXID9 66,316,2002
oral/rat lowest published toxic dose: 2.1 gm/kg/63D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathTOXID9 90,300,2006
oral/rat lowest published toxic dose: 1050 mg/kg/49D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOPADD 33,378,2005
oral/rat lowest published toxic dose: 1050 mg/kg/14D- intermittentBehavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
TOPADD 33,378,2005
oral/rat lowest published toxic dose: 2100 mg/kg/49D- intermittentNutritional and Gross Metabolic: Dehydration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOPADD 33,378,2005
oral/rat lowest published toxic dose: 2100 mg/kg/14D- intermittentSpinal Cord: Other degenerative changes

Behavioral: Tremor

Nutritional and Gross Metabolic: Dehydration
TOPADD 33,378,2005
oral/rat lowest published toxic dose: 4200 mg/kg/49D- intermittentSpinal Cord: Demyelination

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOPADD 33,378,2005
oral/rat lowest published toxic dose: 300 mg/kg/5D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JTEHF8 67,431,2004
oral/rat lowest published toxic dose: 2100 mg/kg/14D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHF8 67,431,2004
oral/rat lowest published toxic dose: 1050 mg/kg/63D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TOXID9 12,468,2008
oral/rat lowest published toxic dose: 4200 mg/kg/63D- intermittentBrain and Coverings: Demyelination

Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TOXID9 -,443,2009
skin/cat lowest published toxic dose: 900 mg/kg/90D- intermittentBehavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 83,126,1986
skin/domestic bird lowest published toxic dose: 6 gm/kg/10D- intermittentSpinal Cord: Other degenerative changesNEZAAQ 52,281,1997
subcutaneous/domestic bird lowest published toxic dose: 2250 mg/kg/5D- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Ataxia

Blood: Other changes
NEZAAQ 47,222,1992
subcutaneous/rat lowest published toxic dose: 4200 mg/kg/50D- intermittentBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 78,276,2004
subcutaneous/rat lowest published toxic dose: 2100 mg/kg/50D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 78,276,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCRTXB2 3,289,1975
TOXICOLOGY REVIEWIRXPAT 3,219,1964
TOXICOLOGY REVIEWCRTXB2 2,365,1973
TOXICOLOGY REVIEWCMTVAS 10(3),49,1973
TOXICOLOGY REVIEWARENAA 26,29,1981
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,441,2005
TOXICOLOGY REVIEWENTOX* -,302,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,689,1995
TOXICOLOGY REVIEWTXCYAC 307,46,2013
TOXICOLOGY REVIEWTXAPA9 270,39,2013
TOXICOLOGY REVIEWFCTOD7 86,298,2015
TOXICOLOGY REVIEWTXCYAC 313,94,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3DTLVS* 3,271,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIORTHOCRESYL PHOSPHATE-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 74600; Number of Industries 1; Total Number of Facilities 20; Number of Occupations 1; Total Number of Employees Exposed 20; Total Number of Female Employees Exposed 20
National Occupational Hazard Survey 1974Hazard Code 74600; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 14

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triorthocresyl phosphate, 5037
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