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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphonothioic acid, phenyl-, O-ethyl O-(p-nitrophenyl)ester

RTECS #

TB1925000

CAS #

2104-64-5; 65580-81-6

Updated

December 2015

Molecular Weight

323.32

Molecular Formula

C14H14NO4PS

Synonyms

Benzenephosphonic acid, thiono-, ethyl-p-nitrophenyl ester
ENT 17,798
EPN
EPN (ACGIH:OSHA)
EPN 300
Ethoxy-4-nitrophenoxyphenylphosphine sulfide
Ethyl p-nitrophenyl benzenethionophosphonate
Ethyl p-nitrophenyl benzenethiophosphate
Ethyl p-nitrophenyl benzenethiophosphonate
Ethyl p-nitrophenyl phenylphosphonothioate
Ethyl p-nitrophenyl thionobenzenephosphate
Ethyl p-nitrophenyl thionobenzenephosphonate
IN-9663-90
O-(4-Nitrophenyl) O-ethyl phenyl thiophosphonate
O-Aethyl-O-(4-nitro-phenyl)-phenyl-monothiophosphonat (German)
O-Ethyl O-(4-nitrophenyl) phenylphosphonothioate
O-Ethyl O-(4-nitrophenyl)benzenethionophosphonate
O-Ethyl O-p-nitrophenyl phenylphosphonothiolate
O-Ethyl O-p-nitrophenyl phenylphosphorothioate
O-Ethyl phenyl p-nitrophenyl thiophosphonate
O-Ethyl-O-((4-nitro-fenyl)-fenyl)-monothiofosfonaat (Dutch)
O-Ethyl-O-p-nitrofenylester kyseliny fenylthiofosfonove (Czech)
O-Etil-O-((4-nitro-fenil)-fenil)-monotiofosfonato (Italian)
OMS 219
Phenol, p-nitro-, O-ester with O-ethyl phenyl phosphonothioate
Phenylphosphonothioate, O-ethyl-O-p-nitrophenyl-
Phenylphosphonothioic acid O-ethyl O-p-nitrophenyl ester
Phenylthiophosphonate de O-ethyle et O-4-nitrophenyle (French)
PIN
Santox

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL moderateNTIS** OTS0540535
skin /rabbit 500 µL moderateNTIS** OTS0540536

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 132 mg/kg (6-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JPFCD2 20,373,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 106 mg/m3/1HPeripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0570820
intraperitoneal/chicken lethal dose (50 percent kill): 17 mg/kgBECTA6 18,534,1977
intraperitoneal/Dog lowest published lethal dose: 35 mg/kgJPETAB 112,29,1954
intraperitoneal/guinea pig lethal dose (10 percent kill): 14 mg/kgTXAPA9 8,259,1966
intraperitoneal/mouse lethal dose (50 percent kill): 8400 µg/kgIJBBBQ 15,336,1978
intraperitoneal/rabbit lowest published lethal dose: 20 mg/kgJPETAB 112,29,1954
intraperitoneal/rat lethal dose (50 percent kill): 7200 µg/kgAPCRAW 4,117,1961
oral/chicken lethal dose (50 percent kill): 5 mg/kgJPFCD2 17,611,1982
oral/Dog lethal dose (50 percent kill): 20 mg/kgPCOC** -,478,1966
oral/duck lethal dose (50 percent kill): 3 mg/kgTXAPA9 20,57,1971
oral/mouse lethal dose (50 percent kill): 12200 µg/kgABCHA6 26,257,1962
oral/pigeon lethal dose (50 percent kill): 4210 µg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 5 mg/kgTXAPA9 20,57,1971
oral/rat lethal dose (50 percent kill): 7 mg/kgJPETAB 112,29,1954
oral/wild bird lethal dose (50 percent kill): 2370 µg/kgASTTA8 (680),157,1979
skin/cat lethal dose (50 percent kill): 45 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia
TOLED5 1000(Sp Iss 1),141,1980
skin/duck lethal dose (50 percent kill): 400 mg/kgTXAPA9 47,451,1979
skin/mouse lethal dose (50 percent kill): 348 mg/kgABCHA6 26,257,1962
skin/rabbit lethal dose (50 percent kill): 30 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes
AFDOAQ 16,3,1952
skin/rat lethal dose (50 percent kill): 25 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
subcutaneous/mouse lethal dose (50 percent kill): 22900 µg/kgTOIZAG 25,635,1978
unreported route/rat lethal dose (50 percent kill): 7 mg/kgJPETAB 128,289,1960

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/chicken lowest published toxic dose: 90 mg/kg/90D- intermittentBehavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 45,685,1978
oral/Dog lowest published toxic dose: 35 mg/kg/4W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 121,96,1957
oral/rat lowest published toxic dose: 84 mg/kg/8W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 121,96,1957
oral/rat lowest published toxic dose: 2700 mg/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 112,29,1954
skin/cat lowest published toxic dose: 180 mg/kg/90D- intermittentSpinal Cord: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 68,54,1983
skin/chicken lowest published toxic dose: 90 mg/kg/90D- intermittentBehavioral: AtaxiaJTEHD6 16,85,1985

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWTXAPA9 47,451,1979
TOXICOLOGY REVIEWTXCYAC 307,136,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,116,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,99,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPN-air10H time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: EPN, 5012
On EPA IRIS database
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