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Registry of Toxic Effects of Chemical Substances (RTECS)

Phenothiazine

RTECS #

SN5075000

CAS #

92-84-2

Updated

September 2013

Molecular Weight

199.28

Molecular Formula

C12H9NS

Synonyms

AFI-Tiazin
Agrazine
Antiverm
Biverm
Contaverm
Dibenzo-1,4-thiazine
Dibenzothiazine
ENT 38
Feeno
Fenothiazine (Dutch)
Fenotiazina (Italian)
Fenoverm
Fentiazin
Helmetina
Lethelmin
Nemazene
Orimon
Padophene
Penthazine
Phenegic
Phenosan
Phenothiazine (ACGIH)
Phenoverm
Phenovis
Phenoxur
Phenthiazine
Reconox
Souframine
Thiodifenylamine (Dutch)
Thiodiphenylamin (German)
Thiodiphenylamine
Tiodifenilamina (Italian)
Wurm-thional
XL-50

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1250 mg/kg (1-22D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)AJANA2 110,29,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lethal dose (50 percent kill): 178 mg/kgCSLNX* NX#00586
oral/cattle lethal dose (50 percent kill): 500 mg/kg85JCAE -,1104,1986
oral/child lowest published lethal dose: 425 mg/kg/5DBehavioral: Headache

Liver: Jaundice, other or unclassified

Blood: Normocytic anemia
LANCAO 242,86,1942
oral/mouse lethal dose (50 percent kill): 5 gm/kgBehavioral: AntipsychoticDNEUD5 7,45,1980
oral/rabbit lethal dose (50 percent kill): 4 gm/kg85JCAE -,1104,1986
unreported route/wild bird lowest published lethal dose: 500 mg/kgJACSAT 66,888,1944

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWPLMJAP 6,160,1975
TOXICOLOGY REVIEWCLCHAU 19,361,1973
TOXICOLOGY REVIEWBLREV* 4,226,1990
TOXICOLOGY REVIEWMEDIAV 37,263,2009
TOXICOLOGY REVIEWNTAPM* -,689,1995

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,198,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3 (skin)DTLVS* 3,204,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, Skin, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENOTHIAZINE-air10H time-weighted average 5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84116; Number of Industries 54; Total Number of Facilities 5473; Number of Occupations 68; Total Number of Employees Exposed 88048; Total Number of Female Employees Exposed 8791
National Occupational Hazard Survey 1974Hazard Code 84116; Number of Industries 5; Total Number of Facilities 175; Number of Occupations 15; Total Number of Employees Exposed 5639

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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