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Registry of Toxic Effects of Chemical Substances (RTECS)

2,4-Pentanediol, 2-methyl-

RTECS #

SA0810000

CAS #

107-41-5

Updated

September 2013

Molecular Weight

118.20

Molecular Formula

C6H14O2

Synonyms

2,4-Dihydroxy-2-methylpentane
2-Methyl pentane-2,4-diol
2-Methyl-2,4-pentanediol
alpha,alpha,alpha'-Trimethyltrimethylene glycol
Diolane
Hexylene glycol
Hexylene glycol (ACGIH)
Isol
Pinakon

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 465 mg open irritation test mildUCDS** 11/3/1971
skin /rabbit 465 mg/24H moderateJPETAB 82,377,1944
skin /rabbit 500 mg/24H moderateFCTXAV 16,777,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 50 ppm/15MOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
34ZIAG -,312,1969
inhalation/human lowest published toxic concentration: 50 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 28,262,1946
intraperitoneal/mouse lethal dose (50 percent kill): 1299 mg/kgSCCUR* -,5,1961
intraperitoneal/rat lowest published lethal dose: 1500 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed
JPPMAB 11,150,1959
oral/guinea pig lethal dose (50 percent kill): 2800 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes
FEPRA7 4,142,1945
oral/mouse lethal dose (50 percent kill): 3097 mg/kgJAPMA8 45,669,1956
oral/rabbit lethal dose (50 percent kill): 3200 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes
FEPRA7 4,142,1945
oral/rat lethal dose (50 percent kill): 3700 mg/kgNPIRI* 1,68,1974
skin/rabbit lethal dose (50 percent kill): 8560 µL/kg34ZIAG -,731,1969
subcutaneous/rabbit lethal dose (50 percent kill): 13 gm/kgSkin: After systemic exposure: Dermatitis, otherFCTXAV 16,777,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 25 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJACTDZ 4(5),223,1985

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,256,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 25 ppm (121 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (49 mg/m3);KZW 10 ppm (49 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 25 ppm (123 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 25 ppm (125 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 25 ppm (120 mg/m3), short term exposure limit 40 ppm (200 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 25 ppm (125 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (49 mg/m3), 2011
Occupational Exposure Limit-ICELANDshort term exposure limit 25 ppm (125 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 25 ppm (125 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 25 ppm (125 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 25 ppm (121 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-SWEDENceiling concentration 25 ppm (120 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (49 mg/m3), KZG-week 20 ppm (98 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 125 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (123 mg/m3);short term exposure limit 25 ppm (123 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXYLENE GLYCOL-airceiling concentration 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 37630; Number of Industries 253; Total Number of Facilities 43088; Number of Occupations 167; Total Number of Employees Exposed 754186; Total Number of Female Employees Exposed 231390
National Occupational Hazard Survey 1974Hazard Code 37630; Number of Industries 224; Total Number of Facilities 30332; Number of Occupations 149; Total Number of Employees Exposed 373068

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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