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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Pentanone

RTECS #

SA7875000

CAS #

107-87-9

Updated

October 2014

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

2-Pentanone (OSHA)
Ethyl acetone
Methyl propyl ketone
Methyl propyl ketone (ACGIH:OSHA)
Methyl-n-propyl ketone
Methylpropyl ketone
Methyl-propyl-cetone (French)
Metylopropyloketon (Polish)
MPK

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 405 mg open irritation test mildUCDS** 7/20/1967

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae13600 ppmMUREAV 149,339,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 50000 mg/m3Gastrointestinal: Changes in structure or function of salivary glandsVCVGK* -,421,1994
inhalation/guinea pig Lowest published lethal concentration: 105000 mg/m3/30MLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,421,1994
inhalation/guinea pig Lowest published lethal concentration: 13000 ppm/5H85INA8 6,1036,1991
inhalation/human lowest published toxic concentration: 1500 ppmEye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
NPIRI* 1,83,1974
inhalation/human lowest published toxic concentration: 3000 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,421,1994
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 22 gm/m3GISAAA 51(5),61,1986
inhalation/mouse lowest published toxic concentration: 15000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,421,1994
inhalation/mouse lethal concentration (50 percent kill): 22000 mg/m3/2HVCVGK* -,421,1994
inhalation/rabbit lowest published toxic concentration: 1250 mg/m3Brain and Coverings: Other degenerative changesVCVGK* -,421,1994
inhalation/rat Lowest published lethal concentration: 2000 ppm/4HHPV057 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 1600 mg/kg38MKAJ 2C,4735,1982
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4735,1982
oral/mammal (species unspecified) lethal dose (50 percent kill): 3700 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 1600 mg/kg38MKAJ 2C,4735,1982
oral/mouse lowest published lethal dose: 1600 mg/kgHPV057 -,-,2001
oral/rat lowest published lethal dose: 3200 mg/kgHPV057 -,-,2001
oral/rat lethal dose (50 percent kill): 1600 mg/kg38MKAJ 2C,4735,1982
skin/rabbit lethal dose (50 percent kill): 6500 mg/kgNPIRI* 1,83,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1074 mg/kg/4D- intermittentLiver: Other changesHPV057 -,-,2001
inhalation/rat lowest published toxic concentration: 5000 mg/m3/35D- intermittentBehavioral: Somnolence (general depressed activity)HPV057 -,-,2001
oral/rat lowest published toxic dose: 177060 mg/kg/52W- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV057 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 150 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 199,203,2010

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (700 mg/m3)DTLVS* 3,200,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (705 mg/m3), short term exposure limit 250 ppm (881 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (700 mg/m3);KZW 400 ppm (1400 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm(715 mg/m3), short term exposure limit 250 ppm(894 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (700 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 200 ppm (710 mg/m3), short term exposure limit 250 ppm (890 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 200 ppm (705 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (700 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (700 mg/m3), short term exposure limit 250 ppm (875 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (700 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (705 mg/m3); short term exposure limit 250 ppm (881 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (705 mg/m3); short term exposure limit 250 ppm (881 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 800 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (700 mg/m3), KZG-week 400 ppm (1400 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 700 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 200 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (716 mg/m3);short term exposure limit 250 ppm (895 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (700 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (700 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (700 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (700 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PROPYL KETONE-air10H time-weighted average 150 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 54480; Number of Industries 17; Total Number of Facilities 930; Number of Occupations 13; Total Number of Employees Exposed 8218; Total Number of Female Employees Exposed 1129
National Occupational Hazard Survey 1974Hazard Code 54480; Number of Industries 4; Total Number of Facilities 39; Number of Occupations 11; Total Number of Employees Exposed 789

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
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