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Registry of Toxic Effects of Chemical Substances (RTECS)

5-Norbornene-2,3-dimethanol, 1,4,5,6,7,7-hexachloro-, cyclic sulfite

RTECS #

RB9275000

CAS #

115-29-7; 6994-04-3; 8003-45-0

Updated

October 2017

Molecular Weight

406.91

Molecular Formula

C9H6Cl6O3S

Synonyms

1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)hepten-5,6-bioxymethylenesulfite
1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dimethanol cyclic sulfite
6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide
6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexahydro-
alpha,beta-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)-2-heptene-5,6-bisoxymethylene sulfite
Benzoepin
Beosit
BIO 5,462
Chlorthiepin
Crisulfan
Devisulphan
Endocel
Endosulfan
Endosulfan (ACGIH:OSHA)
Endosulphan
Endotaf
ENT 23,979
FMC 5462
Goldenleaf tobacco spray
Hexachlorohexahydromethano 2,4,3-benzodioxathiepin-3-oxide
Hildan
HOE 2,671
Insectophene
Kop-thiodan
Malix
NCI-C00566
NIA 5462
Niagara 5,462
OMS 570
Rasayansulfan
RCRA waste number P050
SD-4314
Sulfurous acid, cyclic ester with 1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dimethanol
Thifor
Thimul
Thiodan
Thiodan 35
Thiofor
Thiomul
Thionate
Thionex
Thiosulfan
Thiosulfan tionel
Thiotox
Thiotox (insecticide)
Tiovel

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisunreported route/mouse1 mg/kgTGANAK 16(1),45,1982
Cytogenetic Analysisoral/mouse32 mg/kgIMSCE2 14,1125,1986
Cytogenetic Analysisintraperitoneal/hamster8 mg/kgARTODN 58,152,1986
DNA Damageovary/hamster1 µmol/L/3HEMMUEG 47,682,2006
DNA Damagelymphocyte/human0.05 µmol/L/3HEMMUEG 47,682,2006
DNA Damageother cell types/human80 µmol/L/1DMUTAEX 31,43,2016
DNA Damageother cell types/human30 µmol/L/7DMUTAEX 31,43,2016
Dominant Lethal Testintraperitoneal/mouse83 mg/kg/5D-continuousMUREAV 242,1,1990
micronucleus testother cell types/human30 µmol/L/14DMUTAEX 31,43,2016
micronucleus testmultiple/frog5 µg/L/48H-continuousMUREAV 587,67,2005
mutation in mammalian somatic cellslymphocyte/mouse18600 µg/LEMMUEG 12,85,1988
mutation in microorganisms/Saccharomyes cerevisiae100 mg/L (-enzymatic activation step)TGANAK 18,455,1984
mutation in microorganisms/Salmonella typhimurium1 µg/plate/30MEMMUEG 47,682,2006
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster200 ppm/48HMUREAV 136,115,1984
sister chromatid exchangelymphocyte/human1 µmol/LARTODN 52,221,1983
sperm morphologyoral/rat75 mg/kg/10D- intermittentMUREAV 585,50,2005
sperm morphologyintraperitoneal/mouse83 mg/kg/5D-continuousMUREAV 242,1,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 66 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicBDERB* 86,1,2009
oral/rat 26.23 mg/kg (1-22D preg/21D after birth)Reproductive: Effects on newborn: Delayed effectsTOLED5 197,106,2010
oral/rat 226.44 mg/kg (1-22D preg/15D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOLED5 196S,S314,2010
oral/mouse 151.2 µg/kg (multigeneration)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
TXCYAC 308,74,2013
oral/mouse 151.2 µg/kg (1D preg-21D after birth)Reproductive: Maternal effects: Postpartum

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXCYAC 308,74,2013
oral/rat 26.84 mg/kg (1D preg-21D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TXCYAC 311,35,2013
oral/rat 18.5 mg/kg (7-22D preg/21D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
FCTOD7 99,135,2017
oral/rat 45 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
APTOA6 42,150,1978
oral/rat 600 mg/kg (60D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOLED5 18(Suppl 1),139,1983
oral/rat 125 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 58,79,1997
oral/rat 175 mg/kg (10W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VHTODE 37,547,1995
oral/rat 42 mg/kg (15-21D preg/1-21D after birth)Reproductive: Effects on newborn: PhysicalHETOEA 18,583,1999
oral/rat 10 mg/kg (12-22D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)

Reproductive: Effects on newborn: Delayed effects
ETOPFR 10,29,2001
oral/rat 150 mg/kg (30D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)BECTA6 70,285,2003
oral/rat 450 mg/kg (30D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
BECTA6 70,285,2003
oral/rat 6.2 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects
FEREAC 69,10443,2004
oral/rat 32 mg/kg (21D pre-21D after birth)Reproductive: Paternal effects: Testes, epididymis, sperm ductHETOEA 22,171,2003
oral/rat 257 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TOLED5 176,58,2008
oral/rat 25.6 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOLED5 176,58,2008
oral/rat 220.3 mg/kg (1D preg-15D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOLED5 176,58,2008
oral/rat 22 mg/kg (1D preg-15D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOLED5 176,58,2008
oral/rat 15 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
JAPTO* 27,143,2007
oral/rat 257 mg/kg (1D preg-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 -,245,2009
oral/rat 15 mg/kg (6-20D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JAPTO* 27,589,2007
oral/rat 15 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
JAPTO* 28,901,2008
oral/rat 120 mg/kg (15D preg-22D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsBDERB* 86,1,2009
oral/rat 84 mg/kg (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
BDERB* 86,1,2009
oral/rat 125 mg/kg (1D preg-28D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
BDERB* 86,1,2009
oral/rabbit 92 mg/kg (6-28D pregnant)Reproductive: Other effects on femaleBDERB* 86,1,2009
oral/rat 263.16 mg/kg (1D preg-21D after birth)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Biochemical and metabolic
BDERB* 86,1,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 330 mg/kg/78W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB223-159
subcutaneous/mouse lowest published toxic dose: 2 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver Inhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,718,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 20 µmol/L/72HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.FCTOD7 50,3963,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 40 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TXCYAC 292,23,2012
In Vitro/Human, liver tumor Inhibitor Concentration Low: 30 µmol/L/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseTXCYAC 292,23,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 100.5 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 300,19,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 73.3 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 300,19,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 68.9 µmol/L/72HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 300,19,2012
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 20 µmol/L/48HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 300,19,2012
In Vitro/jrdInhibitor Concentration (50 percent kill): 1.3 µmol/L/6DEndocrine: EstrogenicFCTOD7 62,82,2013
In Vitro/Mouse, liver Inhibitor Concentration Low: 1 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,718,2012
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 0.07 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Non-mammalian species, liver Inhibitor Concentration Low: 100 µmol/L/120HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayFCTOD7 73,157,2014
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
inhalation/cat lethal concentration (50 percent kill): 90 mg/m3/4H85GMAT -,72,1982
inhalation/rat lethal concentration (50 percent kill): 80 mg/m3/4HJOCMA7 9,35,1967
inhalation/rat lethal concentration (50 percent kill): 0.16 gm/m3/4HFEREAC 69,10443,2004
inhalation/rat lethal concentration (50 percent kill): 12.6 mg/m3/4HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BDERB* 86,1,2009
intraperitoneal/hamster lethal dose (50 percent kill): 80 mg/kgARTODN 58,152,1986
intraperitoneal/mouse lethal dose (50 percent kill): 7 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Respiratory stimulation
BECTA6 15,708,1976
intraperitoneal/rat lethal dose (50 percent kill): 8 mg/kgBehavioral: Change in motor activity (specific assay)

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Contraction (isolated tissue)
RREVAH 22,1,1968
intravenous/rat lowest published toxic dose: 5.7 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
NRTXDN 32,31,2011
intravenous/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Recordings from specific areas of CNSNRTXDN 32,31,2011
intravenous/rat lowest published toxic dose: 2 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Vascular: BP elevation not characterized in autonomic section
NRTXDN 32,31,2011
intravenous/rat lowest published toxic dose: 4 mg/kgBrain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold

Vascular: BP elevation not characterized in autonomic section
NRTXDN 32,31,2011
intravenous/woman lowest published toxic dose: 6 µL/kgBehavioral: Muscle weakness

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTCTDW 34,447,1996
oral/cat lethal dose (50 percent kill): 2 mg/kg85DPAN -,-,1971/1976
oral/Dog lethal dose (50 percent kill): 76700 µg/kgPEMNDP 9,332,1991
oral/domestic animal lethal dose (50 percent kill): 26 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
VETNAL 59(12),64,1983
oral/duck lethal dose (50 percent kill): 33 mg/kgDOEAAH 35,25,1979
oral/hamster lethal dose (50 percent kill): 118 mg/kgEJTXAZ 7,159,1974
oral/human lowest published lethal dose: 0.87 gm/kgBehavioral: Convulsions or effect on seizure threshold

Liver: Liver function tests impaired

Musculoskeletal: Other changes
HETOEA 28,309,2009
oral/human lowest published toxic dose: 0.4785 gm/kgBehavioral: Convulsions or effect on seizure threshold

Liver: Liver function tests impaired

Musculoskeletal: Other changes
HETOEA 28,309,2009
oral/human Lethal dose: >0.5 gm/kgHETOEA 28,309,2009
oral/man lowest published lethal dose: 2571 mg/kgBehavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Blood: Changes in bone marrow not included in above
JTCTDW 42,927,2004
oral/man lowest published lethal dose: 429 µL/kgEye: Miosis (pupilliary constriction)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
YAKUD5 34,1232,1992
oral/man lowest published lethal dose: 260 mg/kgBrain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
JTCTDW 36,345,1998
oral/man lowest published toxic dose: 86 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis
JTCTDW 26,265,1988
oral/man lowest published lethal dose: 418 µL/kgOlfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP
AJEMEN 6,510,1988
oral/mouse lethal dose (50 percent kill): 7360 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TOLED5 7,221,1981
oral/rabbit lethal dose (50 percent kill): 28 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
VETNAL 59(12),64,1983
oral/rat lethal dose (50 percent kill): 18 mg/kgARSIM* 20,9,1966
oral/rat lowest published toxic dose: 3 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
FEREAC 69,10443,2004
oral/rat lethal dose (50 percent kill): 10 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Gastritis

Kidney, Ureter, and Bladder: Other changes
BDERB* 86,1,2009
oral/wild bird lethal dose (50 percent kill): 35 mg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 246 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Acute pulmonary edema
JTCTDW 42,927,2004
skin/mammal (species unspecified) lethal dose (50 percent kill): 147 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
VETNAL 59(12),64,1983
skin/rabbit lethal dose (50 percent kill): 90 mg/kgEye: Other eye effects

Skin: After systemic exposure: Dermatitis, irritative
JOCMA7 9,35,1967
skin/rat lethal dose (50 percent kill): 34 mg/kg85GMAT -,72,1982
skin/rat lethal dose (50 percent kill): 74 mg/kgSkin: After topical application: Primary irritationBDERB* 86,1,2009
subcutaneous/rabbit lethal dose (50 percent kill): 360 mg/kgBehavioral: Change in motor activity (specific assay)

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Contraction (isolated tissue)
RREVAH 22,1,1968
Tank with water/other fish lethal concentration (50 percent kill): 0.77 µg/L/96HBehavioral: Alteration of classical conditioningFCTOD7 49,1898,2011
Tank with water/other fish lowest published toxic concentration: 0.0075 µg/L/96HBehavioral: Alteration of classical conditioningFCTOD7 49,1898,2011
Tank with water/other fish lowest published toxic concentration: 0.0025 µg/L/7DEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 49,1898,2011
Tank with water/Zebrafish lowest published toxic concentration: 2.4 µg/L/96HBehavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 33,469,2012
unreported route/mouse lethal dose (50 percent kill): 32 mg/kgTGANAK 16(1),45,1982
unreported route/rat lethal dose (50 percent kill): 40 mg/kg30ZDA9 -,267,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 8.4 mg/kg/6H/21D- intermittentBlood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,10443,2004
inhalation/rat lowest published toxic concentration: 8.4 mg/kg/6H/21D- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FEREAC 69,10443,2004
inhalation/rat lowest published toxic concentration: 2 mg/m3/29D- intermittentBehavioral: Somnolence (general depressed activity)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BDERB* 86,1,2009
inhalation/rat lowest published toxic concentration: 6.5 mg/m3/9D- intermittentBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BDERB* 86,1,2009
intraperitoneal/mouse lowest published toxic dose: 21.7 mg/kg/14D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumNRTXDN 28,727,2007
intraperitoneal/rabbit lowest published toxic dose: 650 mg/kg/65W- intermittentEye: Retinal changes pigmentary deposition, retinitis, other)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Conditioned vitamin deficiency
JTOTDO 6,161,1987
intraperitoneal/rat lowest published toxic dose: 35 mg/kg/5W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Aggression
BDERB* 86,1,2009
intraperitoneal/rat lowest published toxic dose: 90 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Aggression

Biochemical: Metabolism (intermediary): Other
BDERB* 86,1,2009
intratracheal/rat lowest published toxic dose: 30 mg/kg/3D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 34,63,1985
oral/chicken lowest published toxic dose: 19.6 mg/kg/8W- continuousMusculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TOPADD 32,364,2004
oral/chicken lowest published toxic dose: 315 mg/kg/60D- continuousBlood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TXAPA9 197,278,2004
oral/chicken lowest published toxic dose: 315 mg/kg/60D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TXCYAC 251,51,2008
oral/Dog lowest published toxic dose: 2745 mg/kg/0.5Y- intermittentGastrointestinal: Other changesFEREAC 69,10443,2004
oral/Dog lowest published toxic dose: 638.75 mg/kg/1Y- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,10443,2004
oral/Dog lowest published toxic dose: 643.72 mg/kg/44W- intermittentBehavioral: Convulsions or effect on seizure threshold

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BDERB* 86,1,2009
oral/mouse lowest published toxic dose: 105 mg/kg/35D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BDERB* 86,1,2009
oral/mouse lowest published toxic dose: 45 mg/kg/15D- intermittentReproductive: Maternal effects: Oogenesis

Related to Chronic Data: Changes in ovarian weight
BDERB* 86,1,2009
oral/mouse lowest published toxic dose: 120 mg/kg/30D- intermittentLiver: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 71,458,2003
oral/mouse lowest published toxic dose: 664.3 mg/kg/13W- intermittentRelated to Chronic Data: Changes in uterine weightFEREAC 69,10443,2004
oral/mouse lowest published toxic dose: 105 mg/kg/7D- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 148,158,1998
oral/mouse lowest published toxic dose: 1934.5 mg/kg/2Y- intermittentRelated to Chronic Data: Changes in uterine weightFEREAC 69,10443,2004
oral/mouse lowest published toxic dose: 468.72 mg/kg/27W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldBDERB* 86,1,2009
oral/rabbit lowest published toxic dose: 92 mg/kg/23D- intermittentBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 225 mg/kg/90D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)BDERB* 86,1,2009
oral/rat lowest published toxic dose: 125 mg/kg/50D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 144 mg/kg/24D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 180 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 600.6 mg/kg/13W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 308 mg/kg/8W- intermittentBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 75 mg/kg/15D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
FCTOD7 64,1,2014
oral/rat lowest published toxic dose: 2111.2 mg/kg/104W- intermittentVascular: Structural changes in vessels

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 150 mg/kg/30D- intermittentEndocrine: Androgenic

Endocrine: Other changes
TOLED5 180S,S188,2008
oral/rat lowest published toxic dose: 15 mg/kg/15D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
JAPTO* 27,589,2007
oral/rat lowest published toxic dose: 2130.31 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 2472.47 mg/kg/13W- intermittentLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 150 mg/kg/15D- intermittentLiver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BDERB* 86,1,2009
oral/rat lowest published toxic dose: 15 mg/kg/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 27,143,2007
oral/rat lowest published toxic dose: 28 mg/kg/2W- intermittentGastrointestinal: Changes in structure or function of exocrine pancreasTXCYAC 200,205,2004
oral/rat lowest published toxic dose: 42 mg/kg/3W- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 200,205,2004
oral/rat lowest published toxic dose: 84 mg/kg/6W- intermittentCardiac: Cardiomyopathy including infarction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 202,227,2004
oral/rat lowest published toxic dose: 75 mg/kg/10D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
MUREAV 585,50,2005
oral/rat lowest published toxic dose: 75 mg/kg/10D- intermittentEndocrine: Androgenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Reproductive: Paternal effects: Testes, epididymis, sperm duct
MUREAV 585,50,2005
oral/rat lowest published toxic dose: 150 mg/kg/15D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
BECTA6 18,378,1977
oral/rat lowest published toxic dose: 450 mg/kg/60D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 21,29,1984
oral/rat lowest published toxic dose: 840 mg/kg/7W- intermittentEndocrine: Hyperglycemia

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
TOLED5 5,119,1980
oral/rat lowest published toxic dose: 185 mg/kg/22W- continuousEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
ARTODN 59,279,1986
oral/rat lowest published toxic dose: 45 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
INHEAO 22,295,1984
oral/rat lowest published toxic dose: 126 mg/kg/6W- continuousLiver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
BECTA6 38,435,1987
oral/rat lowest published toxic dose: 136.5 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
FEREAC 69,10443,2004
oral/rat lowest published toxic dose: 2482 mg/kg/2Y- intermittentVascular: Structural changes in vessels

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,10443,2004
skin/rat lowest published toxic dose: 567 mg/kg/21D- intermittentRelated to Chronic Data: Changes in uterine weightFEREAC 69,10443,2004
subcutaneous/rat lowest published toxic dose: 250 mg/kg/10D- intermittentBehavioral: ExcitementNETEEC 24,797,2002
subcutaneous/rat lowest published toxic dose: 67.5 mg/kg/15D- intermittentRelated to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in testicular weight

Related to Chronic Data: Changes in uterine weight
BDERB* 86,1,2009
unreported route/mouse lowest published toxic dose: 52.5 mg/kg/7D- intermittentEndocrine: Androgenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other
BDERB* 86,1,2009
unreported route/rat lowest published toxic dose: 150 mg/kg/10W- intermittentLiver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Metabolism (intermediary): Lipids including transport
BDERB* 86,1,2009
unreported route/rat lowest published toxic dose: 50 mg/kg/4D- intermittentEndocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
HBPTO* 1,879,2001
unreported route/rat lowest published toxic dose: 50 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on Na-K pump
HBPTO* 1,879,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWTXCYAC 13,115,1979
TOXICOLOGY REVIEWETOPFR 7,156,2002
TOXICOLOGY REVIEWGISAAA -,18,1993
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWBPCEM* 16,105,2002
TOXICOLOGY REVIEWENTOX* -,174,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 71,24615,2006
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWSIMEJ* 47,1030,2006
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWREPTED 33,269,2012
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTXCYAC 307,74,2013
TOXICOLOGY REVIEWTXCYAC 307,89,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWMUREAV 767,67,2016
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,117,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 mg/m3 (skin)DTLVS* 3,97,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.2 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-INDIAtime-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1910.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDOSULFAN-air10H time-weighted average 0.1 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 28880; Number of Industries 1; Total Number of Facilities 291; Number of Occupations 1; Total Number of Employees Exposed 3205
National Occupational Hazard Survey 1974Hazard Code 28880; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 8; Total Number of Employees Exposed 605

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108023)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-62,1977
On EPA IRIS database
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