Nitrogen dioxide

RTECS #
QW9800000
CAS #
10102-44-0
See: NMAM or OSHA Methods
Updated
December 2017
Molecular Weight
46.01
Molecular Formula
NO2
Synonyms
Azote (French)
Azoto (Italian)
Nitrito
Nitrogen dioxide (ACGIH:OSHA)
Nitrogen peroxide
RCRA waste number P078
Stickstoffdioxid (German)
Stikstofdioxyde (Dutch)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat27 ppm/3H-continuousMUREAV 136,119,1984
Cytogenetic Analysisfibroblast/hamster10 ppm/10M-continuousMUREAV 89,303,1981
DNA adductinhalation/rat108 mg/kg/300D- intermittentCALEDQ 139,189,1999
DNA Damageother cell types/human0.01 ppm/30MTXAPA9 245,219,2010
DNA Damagelung/hamster10 ppmCRNGDP 11,37,1990
DNA repairother cell types/human1 ppm/30MTOLED5 207,89,2011
micronucleus testother cell types/human0.1 ppm/3HTOLED5 207,89,2011
mutation in mammalian somatic cellsinhalation/rat15 ppm/3H-continuousMUREAV 136,119,1984
mutation in microorganisms/Salmonella typhimurium6 ppm (+enzymatic activation step)MUREAV 136,119,1984
mutation in microorganisms/Salmonella typhimurium5 ppm (-enzymatic activation step)EMMUEG 11,65,1988
mutation in microorganisms/Escherichia coli198 µg/L (-enzymatic activation step)MUREAV 162,1,1986
other mutation test systems/Escherichia coli297 µg/LMUREAV 162,1,1986
other mutation test systems/Salmonella typhimurium50 ppmMUREAV 192,239,1987
sister chromatid exchangelung/hamster5 ppm/10M-continuousMUREAV 89,303,1981
Unscheduled DNA Synthesisinhalation/rat30 ppm/1HENVRAL 27,352,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 10 mg/m3/6H (1-22D pregnant)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTOTDY 7,785,1985
inhalation/rat 85 µg/m3/24H (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 42(12),22,1977
inhalation/rat 800 µg/m3/24H (1-22D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)GISAAA 42(12),22,1977
inhalation/rat 2360 µg/m3/12H (12W prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HYSAAV 36(7-9),178,1971
inhalation/rat 100 µg/m3/6H (1-22D pregnant)Reproductive: Effects on newborn: BehavioralNTOTDY 7,785,1985
inhalation/mouse 22 ppm (7-18D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NRTXDN 9,545,1988
inhalation/rat 40 pph (8-10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
VCVN5* -,37,1989
inhalation/rat 40 pph (12-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
VCVN5* -,37,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 108 mg/kg/300D- intermittentTumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens

Lung, Thorax, or Respiration: Tumors
CALEDQ 139,189,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 123 mg/m3/8HOlfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,160,1966
inhalation/Dog lowest published toxic concentration: 19 mg/m3/6HBlood: Methemoglobinemia- CarboxhemoglobinemiaVCVN5* -,35,1993
inhalation/Dog lowest published toxic concentration: 37.2 ppm/4HLung, Thorax, or Respiration: Acute pulmonary edemaEXMPA6 33,90,1980
inhalation/Dog Lowest published lethal concentration: 110 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,35,1993
inhalation/guinea pig lethal concentration (50 percent kill): 30 ppm/1HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Methemoglobinemia- Carboxhemoglobinemia
AEHLAU 10,220,1965
inhalation/guinea pig lethal concentration (50 percent kill): 900 mg/m3/30MVCVN5* -,28,1993
inhalation/human lowest published toxic concentration: 200 mg/m3Lung, Thorax, or Respiration: CoughVCVN5* -,28,1993
inhalation/human lowest published toxic concentration: 90 mg/m3/15MOlfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
VCVN5* -,28,1993
inhalation/human Lowest published lethal concentration: 200 ppm/1MAOHYA3 17,159,1974
inhalation/human lowest published toxic concentration: 0.5 ppm/2HEye: Conjunctiva irritation

Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea
TOXID9 44,301,2005
inhalation/human lowest published toxic concentration: 0.059 mg/m3/5MBrain and Coverings: Changes in surface EEGVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 14 mg/m3Eye: Conjunctiva irritationVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 120 mg/m3Lung, Thorax, or Respiration: DyspneaVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 70 mg/m3Behavioral: Muscle weaknessVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 38 mg/m3/2HBlood: Methemoglobinemia- CarboxhemoglobinemiaVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 510 mg/m3/5MLung, Thorax, or Respiration: Other changesVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 950 mg/m3/5MLung, Thorax, or Respiration: Acute pulmonary edemaVCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 0.2 mg/m3Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough
VCVN5* -,36,1993
inhalation/human lowest published toxic concentration: 0.14 mg/m3/5HEye: Other eye effectsVCVN5* -,36,1993
inhalation/man lowest published toxic concentration: 30 ppm/70MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
TOXID9 44,301,2005
inhalation/man lowest published toxic concentration: 30 ppm/70MLung, Thorax, or Respiration: SputumTOXID9 44,301,2005
inhalation/man lowest published toxic concentration: 2 ppm/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
INHTE5 11,89,1999
inhalation/man lowest published toxic concentration: 6200 ppb/10MLung, Thorax, or Respiration: Changes in pulmonary vascular resistanceKEKHA7 17,337,1968
inhalation/man lowest published toxic concentration: 90 ppm/40MLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
JOCMA7 8,301,1966
inhalation/monkey Lowest published lethal concentration: 123 mg/m3/8HOlfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 9,160,1966
inhalation/monkey lowest published toxic concentration: 50 ppm/2HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
TOXID9 44,301,2005
inhalation/monkey Lowest published lethal concentration: 95 mg/m3/2HVCVN5* -,36,1993
inhalation/mouse lethal concentration (50 percent kill): 800 mg/m3/25MVCVN5* -,28,1993
inhalation/mouse lethal concentration (50 percent kill): 1000 ppm/10MBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
JCTODH 4,246,1977
inhalation/mouse lethal concentration (50 percent kill): 900 mg/m3/2HVCVN5* -,35,1993
inhalation/mouse lowest published toxic concentration: 9.5 mg/m3/1HBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN5* -,35,1993
inhalation/rabbit lethal concentration (50 percent kill): 315 ppm/15MLung, Thorax, or Respiration: Respiratory depression

Eye: Conjunctiva irritation
AIHAAP 23,457,1962
inhalation/rabbit lethal concentration (50 percent kill): 60 mg/m3/15MVCVN5* -,35,1993
inhalation/rabbit lethal concentration (50 percent kill): 12 mg/m3/15MEye: Conjunctiva irritationVCVN5* -,35,1993
inhalation/rabbit lowest published toxic concentration: 28 mg/m3/3HImmunological Including Allergic: Decrease in cellular immune responseVCVN5* -,35,1993
inhalation/rat lethal concentration (50 percent kill): 220 mg/m3/1HLung, Thorax, or Respiration: Acute pulmonary edemaVCVN5* -,35,1993
inhalation/rat lethal concentration (50 percent kill): 310 mg/m3/30MLung, Thorax, or Respiration: Acute pulmonary edemaVCVN5* -,35,1993
inhalation/rat lethal concentration (50 percent kill): 790 mg/m3/5MLung, Thorax, or Respiration: Acute pulmonary edemaVCVN5* -,35,1993
inhalation/rat lowest published toxic concentration: 4 mg/m3/17HLung, Thorax, or Respiration: Other changesVCVN5* -,35,1993
inhalation/rat lowest published toxic concentration: 32 mg/m3/2HLung, Thorax, or Respiration: Ciliary function changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVN5* -,35,1993
inhalation/rat lowest published toxic concentration: 25 mg/m3/2HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,35,1993
inhalation/rat lowest published toxic concentration: 22.7 mg/m3/4HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Endocrine: Other changes
VCVN5* -,35,1993
inhalation/rat lowest published toxic concentration: 1.9 mg/m3/4HLung, Thorax, or Respiration: Other changesVCVN5* -,35,1993
inhalation/rat lethal concentration (50 percent kill): 200 ppm/30MENTOX* -,639,2005
inhalation/rat lethal concentration (50 percent kill): 88 ppm/4HENTOX* -,244,2005
inhalation/rat lowest published toxic concentration: 58 mg/m3/4HLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Changes in adrenal weight
TPKVAL 15,53,1979
inhalation/rat lowest published toxic concentration: 20 mg/m3/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsTPKVAL 15,53,1979
inhalation/rat lowest published toxic concentration: 0.00475 gm/m3/4HBehavioral: Alteration of classical conditioningTPKVAL 9,37,1967
inhalation/rat lowest published toxic concentration: 44.93 mg/m3/4HKidney, Ureter, and Bladder: Other changes

Blood: Changes in bone marrow not included in above
TOVEFN (4),23,2006
inhalation/rat lowest published toxic concentration: 10.1 mg/m3/48HLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in bone marrow not included in above
TOVEFN (4),23,2006
inhalation/rat lowest published toxic concentration: 20 ppm/20HLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 6,149,1980
inhalation/rat lowest published toxic concentration: 200 ppm/15MLung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 184,1,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 15 ppm/24H/10W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
AEHLAU 10,220,1965
inhalation/guinea pig lowest published toxic concentration: 3284 µg/m3/8H/26W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCTKAG 8,241,1975
inhalation/guinea pig lowest published toxic concentration: 68 mg/m3/8H/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/guinea pig lowest published toxic concentration: 17 mg/m3/24H/4W- continuousLung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Effect on specific coenzyme: Proportion of isoenzymes
VCVN5* -,37,1989
inhalation/guinea pig lowest published toxic concentration: 22 mg/m3/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/guinea pig lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittentImmunological Including Allergic: Decreased immune responseVCVN5* -,38,1989
inhalation/guinea pig lowest published toxic concentration: 5 ppm/2H/35D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
JPFCD2 B27,53,1992
inhalation/guinea pig lowest published toxic concentration: 5800 µg/m3/4H/91D- intermittentOlfaction: Change in sensation of smell

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,53,1979
inhalation/guinea pig lowest published toxic concentration: 5800 µg/m3/4H/8D- intermittentLung, Thorax, or Respiration: Other changesTPKVAL 15,53,1979
inhalation/guinea pig lowest published toxic concentration: 5800 µg/m3/4H/17W- intermittentBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
TPKVAL 15,53,1979
inhalation/hamster lowest published toxic concentration: 30 ppm/22H/36W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiEXLRDA 11,179,1986
inhalation/human lowest published toxic concentration: 1.9 mg/m3/2H/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,36,1989
inhalation/human lowest published toxic concentration: 0.8 mg/m3/3Y- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Change in clotting factors
VCVN5* -,38,1989
inhalation/mammal (species unspecified) lowest published toxic concentration: 10 ppm/4H/15W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes
TOLED5 73,241,1994
inhalation/monkey lowest published toxic concentration: 68 mg/m3/8H/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/monkey lowest published toxic concentration: 22 mg/m3/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/monkey lowest published toxic concentration: 9.5 mg/m3/24H/8W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,36,1989
inhalation/mouse lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittentImmunological Including Allergic: Decreased immune responseVCVN5* -,38,1989
inhalation/mouse lowest published toxic concentration: 0.7 ppm/2H/3D- intermittentLung, Thorax, or Respiration: Other changesJTEHD6 65,1999,2002
inhalation/mouse lowest published toxic concentration: 0.7 ppm/3D- intermittentBiochemical: Metabolism (intermediary): Other

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 1,71,2001
inhalation/mouse lowest published toxic concentration: 5 ppm/4H/3D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,295,2008
inhalation/mouse lowest published toxic concentration: 25 ppm/4H/3D- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,295,2008
inhalation/mouse lowest published toxic concentration: 9.5 mg/m3/6H/1Y- intermittentLung, Thorax, or Respiration: TumorsVCVN5* -,37,1989
inhalation/mouse lowest published toxic concentration: 5.7 mg/m3/2H/15W- intermittentBlood: Normocytic anemia

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,37,1989
inhalation/mouse lowest published toxic concentration: 5.7 mg/m3/2H/1Y- intermittentLung, Thorax, or Respiration: Other changesVCVN5* -,37,1989
inhalation/mouse lowest published toxic concentration: 250 ppb/7H/7W- intermittentBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
JTEHD6 25,247,1988
inhalation/mouse lowest published toxic concentration: 20 ppm/24H/4D- continuousEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 42,446,1987
inhalation/mouse lowest published toxic concentration: 10 ppm/2H/30W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Pigmented or nucleated red blood cells
ENVRAL 19,154,1979
inhalation/mouse lowest published toxic concentration: 500 ppb/30D- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiNKYZA2 10,16,1972
inhalation/rabbit lowest published toxic concentration: 68 mg/m3/8H/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/rabbit lowest published toxic concentration: 22 mg/m3/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/rat lowest published toxic concentration: 50 mg/m3/24H/2W- continuousBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema
VCVN5* -,37,1989
inhalation/rat lowest published toxic concentration: 17 mg/m3/4H/10D- intermittentLung, Thorax, or Respiration: Other changesVCVN5* -,37,1989
inhalation/rat lowest published toxic concentration: 5 mg/m3/5D/39W- continuousLung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,38,1989
inhalation/rat lowest published toxic concentration: 5 mg/m3/5H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,38,1989
inhalation/rat lowest published toxic concentration: 3.8 mg/m3/24H/2Y- continuousLung, Thorax, or Respiration: Ciliary function changesVCVN5* -,38,1989
inhalation/rat lowest published toxic concentration: 2.4 mg/m3/12H/13W- intermittentEndocrine: Effect on menstrual cycleVCVN5* -,38,1989
inhalation/rat lowest published toxic concentration: 0.9 mg/m3/6H/13W- intermittentImmunological Including Allergic: Decreased immune responseVCVN5* -,38,1989
inhalation/rat lowest published toxic concentration: 68 mg/m3/8H/6W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/rat lowest published toxic concentration: 22 mg/m3/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN5* -,37,1989
inhalation/rat lowest published toxic concentration: 10 ppm/3D- continuousLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response
TOLED5 121,135,2001
inhalation/rat lowest published toxic concentration: 2 ppm/24H/14D- continuousLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JTEHD6 15,23,1985
inhalation/rat lowest published toxic concentration: 16 ppm/23H/74W- continuousLung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in lung weight
ARDSBL 121,541,1980
inhalation/rat lowest published toxic concentration: 5700 µg/m3/6H/26W- intermittentEndocrine: Other changesGISAAA 26(12),79,1961
inhalation/rat lowest published toxic concentration: 3 ppm/24H/39W- continuousLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport
AEHLAU 26,156,1973
inhalation/rat lowest published toxic concentration: 2 ppm/24H/1Y- continuousLung, Thorax, or Respiration: Changes in lung weightAEHLAU 17,181,1968
inhalation/rat lowest published toxic concentration: 4 ppm/24H/14W- continuousLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
ENVRAL 41,184,1986
inhalation/rat lowest published toxic concentration: 8 ppm/24H/7D- continuousLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
AECTCV 15,733,1986
inhalation/rat lowest published toxic concentration: 5 ppm/24H/4W- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 40,139,1988
inhalation/rat lowest published toxic concentration: 5 mg/m3/6H/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 214,120,2012
inhalation/rat lowest published toxic concentration: 5800 µg/m3/4H/91D- intermittentOlfaction: Change in sensation of smell

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,53,1979
inhalation/rat lowest published toxic concentration: 5800 µg/m3/4H/8D- intermittentLung, Thorax, or Respiration: Other changesTPKVAL 15,53,1979
inhalation/rat lowest published toxic concentration: 5800 µg/m3/4H/17W- intermittentBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
TPKVAL 15,53,1979
inhalation/rat lowest published toxic concentration: 0.6 mg/m3/24H/13W- continuousPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)
VCVN5* -,38,1989

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEWFEPRA7 35,89,1976
TOXICOLOGY REVIEWNTIS** PB228-002
TOXICOLOGY REVIEWCTOXAO 7,145,1974
TOXICOLOGY REVIEWAEHLAU 16,903,1968
TOXICOLOGY REVIEWNTIS** CONF-691001
TOXICOLOGY REVIEWAEHLAU 12,522,1966
TOXICOLOGY REVIEWXPHBAO 272,1,1941
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWDIMON* 46,551,2000
TOXICOLOGY REVIEWENTOX* -,639,2005
TOXICOLOGY REVIEWENTOX* -,244,2005
TOXICOLOGY REVIEWHUTOX* -,661,1996
TOXICOLOGY REVIEWMUREAV 543,195,2003
TOXICOLOGY REVIEWMUREAV 674,45,2009
TOXICOLOGY REVIEWMUREAV 674,62,2009
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,36,2007
TOXICOLOGY REVIEWMUREAV 690,3,2010
TOXICOLOGY REVIEWREPTED 31,363,2011
TOXICOLOGY REVIEWMUREAV 717,38,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUTAEX 28,485,2013
TOXICOLOGY REVIEWMUREAV 762,133,2014
TOXICOLOGY REVIEWTXCYAC 313,3,2013
TOXICOLOGY REVIEWMUREAV 770,170,2016

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 5 ppm (9 mg/m3)DTLVS* 3,185,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 3 ppm (6 mg/m3);KZW 6 ppm (12 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 5 ppm (9.5 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 2 ppm (4 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 6 ppm (11 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 3 ppm (6 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 ppm (0.95 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 9 mg/m3, short term exposure limit 9 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 3 ppm (5.5 mg/m3), short term exposure limit 5 ppm (9 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 3 ppm (6 mg/m3), short term exposure limit 5 ppm (10 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 3 ppm (6 mg/m3);short term exposure limit 5 ppm (10 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 ppm (5.6 mg/m3), short term exposure limit 5 ppm (9.4 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 3 ppm (5,6 mg/m3); short term exposure limit 5 ppm (9,4 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (4 mg/m3), ceiling concentration 5 ppm (10 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 3 ppm (6 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 ppm (9 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 ppm (9 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 ppm (9 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 ppm (9 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN DIOXIDE-airshort term exposure limit 1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 50870; Number of Industries 5; Total Number of Facilities 94; Number of Occupations 24; Total Number of Employees Exposed 18737; Total Number of Female Employees Exposed 1773
National Occupational Hazard Survey 1974Hazard Code 50870; Number of Industries 16; Total Number of Facilities 424; Number of Occupations 19; Total Number of Employees Exposed 11419

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-109
OSHA ANALYTICAL METHOD #ID-182
Page last reviewed: November 16, 2018