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Registry of Toxic Effects of Chemical Substances (RTECS)

4,7-Methanoindene, 3a,4,7,7a-tetrahydro-

RTECS #

PC1050000

CAS #

77-73-6

Updated

September 2013

Molecular Weight

132.22

Molecular Formula

C10H12

Synonyms

1,3-Cyclopentadiene, dimer
3a,4,7,7a-Tetrahydro-4,7-methanoindene
Bicyclopentadiene
Biscyclopentadiene
Dicyclopentadiene
Dicyclopentadiene (ACGIH)
Dicyklopentadien (Czech)
Dimer cyklopentadienu (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 9300 µg/24H open irritation test severeAIHAAP 23,95,1962
skin /rabbit 20 mg/24H moderate85JCAE -,50,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 22400 mg/kg (multigeneration)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 15,166,1995
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV369 -,-,2001
oral/rabbit 1400 mg/kg (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion
HPV369 -,-,2001
oral/rabbit 5600 mg/kg (6-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV369 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 773 ppm/1HTXAPA9 20,552,1971
inhalation/guinea pig lethal concentration (50 percent kill): 770 ppm/4HTXAPA9 20,552,1971
inhalation/guinea pig lethal concentration (50 percent kill): 2100 mg/m3VCVGH* -,106,1990
inhalation/human lowest published toxic concentration: 16 mg/m3Behavioral: HeadacheVCVGH* -,106,1990
inhalation/mouse lethal concentration (50 percent kill): 130 ppm/6HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HPV369 -,-,2001
inhalation/mouse lethal concentration (50 percent kill): 400 mg/m3/2HVCVGH* -,106,1990
inhalation/mouse lethal concentration (50 percent kill): 145 ppm/4HTXAPA9 20,552,1971
inhalation/rabbit lethal concentration (50 percent kill): 771 ppm/4HTXAPA9 20,552,1971
inhalation/rabbit lethal concentration (50 percent kill): 4200 mg/m3VCVGH* -,106,1990
inhalation/rat lethal concentration (50 percent kill): 610 mg/m3/4HVCVGH* -,106,1990
inhalation/rat lethal concentration (50 percent kill): 660 ppm/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
NTIS** OTS0557739
inhalation/rat lethal concentration (50 percent kill): 284 ppm/6HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HPV369 -,-,2001
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 960 mg/kgNTIS** AD-A087-257
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgNCIUS* PH43-64-886
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgNCIUS* PH43-64-886
oral/cattle lethal dose (50 percent kill): 1200 mg/kgBehavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** AD-A093-673
oral/domestic bird lethal dose (50 percent kill): 1010 mg/kgNTIS** AD-A087-257
oral/mouse lethal dose (50 percent kill): 190 mg/kgVCVGH* -,106,1990
oral/rat lethal dose (50 percent kill): 353 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
TXAPA9 20,552,1971
oral/rat lethal dose (50 percent kill): 520 mg/kgBehavioral: Convulsions or effect on seizure thresholdVCVGH* -,106,1990
oral/rat lethal dose (50 percent kill): 370 mg/kgVCVGH* -,106,1990
skin/rabbit lethal dose (50 percent kill): 5080 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
TXAPA9 20,552,1971
skin/rabbit lethal dose (50 percent kill): 5.08 mL/kgVCVGH* -,107,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 72 ppm/7H/2W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 20,552,1971
inhalation/mouse lowest published toxic concentration: 714 ppm/6H/11D- continuousLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0536197
inhalation/mouse lowest published toxic concentration: 51 ppm/13W- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV369 -,,2001
inhalation/rat lowest published toxic concentration: 1 ppm/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)HPV369 -,,2001
inhalation/rat lowest published toxic concentration: 250 ppm/6H/2W- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
inhalation/rat lowest published toxic concentration: 35 ppm/7H/18W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 20,552,1971
inhalation/rat lowest published toxic concentration: 5 ppm/6H/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: P
TIHEEC 8,353,1992
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/26W- intermittentBehavioral: Excitement

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Proteinuria
GTPZAB 9(12),13,1965
oral/rat lowest published toxic dose: 182 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 51(2),77,1986
oral/rat lowest published toxic dose: 1120 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (108),71,1990
oral/rat lowest published toxic dose: 2000 mg/kg/10D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV369 -,,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWNTAPM* -,629,1995

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (27 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (3 mg/m3);KZW 1 ppm (6 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (27 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.7 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 1 ppm (5.5 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 ppm (2.7 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.7 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (30 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (30 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (27 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.5 ppm (3 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (27 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENE-air10H time-weighted average 5 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 83439; Number of Industries 4; Total Number of Facilities 252; Number of Occupations 8; Total Number of Employees Exposed 6248; Total Number of Female Employees Exposed 442
National Occupational Hazard Survey 1974Hazard Code 83439; Number of Industries 24; Total Number of Facilities 2292; Number of Occupations 38; Total Number of Employees Exposed 41365

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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