Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-

RTECS #

PB9800000

CAS #

57-74-9; 39400-80-1; 53637-13-1

Updated

December 2016

Molecular Weight

409.76

Molecular Formula

C10H6Cl8

Synonyms

1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane
1,2,4,5,6,7,8,8-Octachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indaan (Dutch)
1,2,4,5,6,7,8,8-Octachlor-2,3,3a,4,7,7a-hexahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachlor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indan (German)
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-hexahydro-4,7-methylene indane
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane
1,2,4,5,6,7,8,8-Octahydro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindan
1,2,4,5,6,7,8,8-Ottochloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indano (Italian)
4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-
Aspon-chlordane
BELT
CD 68
Chloordaan (Dutch)
Chlor KIL
Chlordan
Chlordane
Chlordane (ACGIH:OSHA)
Chlorindan
Chlorodane
Chlortox
Clordan (Italian)
Clordano
Cortilan-neu
Dichlorochlordene
Dowchlor
ENT 25,552-X
ENT 9,932
HCS 3260
Kilex lindane
Kypchlor
Latka 1068 (Czech)
M 140
NCI-C00099
Octachlor
Octachloro-4,7-methanohydroindane
Octachloro-4,7-methanotetrahydroindane
Octachlorodihydrodicyclopentadiene
Octa-klor
Oktaterr
OMS 1437
Ortho-klor
RCRA waste number U036
SD 5532
Shell SD-5532
Starchlor
Synklor
TAT chlor 4
Termi-ded
Topichlor 20
Topiclor
Topiclor 20
Toxichlor
Unexan-koeder
Velsicol 1068

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse10 mg/kgMUREAV 301,33,1993
morphological transformoral/rat1260 mg/kg/6WCRNGDP 9,387,1988
mutation in mammalian somatic cellslung/hamster10 µmol/LCBINA8 19,369,1977
other mutation test systemsoral/mouse35 mg/kgMUREAV 343,157,1995
phage inhibition capacity/Escherichia coli3050 µmol/LMUREAV 182,193,1987
sister chromatid exchangemultiple/other fish54 pmol/LMUREAV 118,61,1983
sister chromatid exchangelymphocyte/human10 µmol/LARTODN 52,221,1983
Unscheduled DNA Synthesisfibroblast/human1 µmol/LMUREAV 42,161,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 3360 µg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic
JEPTDQ 2(2),357,1978
oral/mouse 152 mg/kg (1-19D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTXAPA9 62,402,1982
oral/mouse 7 mg/kg (15-21D pregnant)Reproductive: Effects on newborn: BehavioralBJPCBM 49,311,1973
oral/mouse 3040 µg/kg (1-19D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicENVRAL 35,204,1984
oral/mouse 2625 mg/kg (5W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 115,1,2000
unreported route/mouse 168 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: Delayed effectsAPTOD9 19,A18,1980
unreported route/mouse 168 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTJADAB 19,23A,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2020 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-8,1977
oral/mouse toxic dose: 3780 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-8,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 24 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 39 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 15 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 47 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 2,1,1988
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 4 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 247,10,2010
In Vitro/Rat, neurons Inhibitor Concentration Low: 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysNRTXDN 44,204,2014
inhalation/cat lethal concentration (50 percent kill): 100 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GTPZAB 8(4),30,1964
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): >20 gm/m3/4HPEMNDP 9,139,1991
intraperitoneal/mouse lowest published lethal dose: 240 mg/kgTXAPA9 23,288,1972
intraperitoneal/rat lethal dose (50 percent kill): 343 mg/kgTXAPA9 32,443,1975
intraperitoneal/rat lowest published toxic dose: 25 mg/kgBiochemical: Metabolism (intermediary): OtherENDOAO 82,406,1968
intravenous/mouse lethal dose (50 percent kill): 100 mg/kgCSLNX* NX#04876
intravenous/rabbit lowest published lethal dose: 10 mg/kgAIHOAX 1,13,1950
oral/cat lethal dose (50 percent kill): 100 mg/kgVCVGH* -,565,1990
oral/chicken lethal dose (50 percent kill): 220 mg/kgPCOC** -,226,1966
oral/domestic animal lethal dose (50 percent kill): 50 mg/kgYKYUA6 32,471,1981
oral/duck lethal dose (50 percent kill): 1200 mg/kgDOEAAH 35,25,1979
oral/hamster lethal dose (50 percent kill): 1720 mg/kgEJTXAZ 7,159,1974
oral/human lowest published lethal dose: 29 mg/kgLiver: Fatty liver degenerationCMEP** -,1,1956
oral/mammal (species unspecified) lethal dose (50 percent kill): 180 mg/kgPCOC** -,226,1966
oral/man lowest published toxic dose: 3071 µg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting
JTCTDW 20,291,1983
oral/mouse lethal dose (50 percent kill): 145 mg/kgARSIM* 20,19,1966
oral/rabbit lethal dose (50 percent kill): 100 mg/kgPCOC** -,226,1966
oral/rat lethal dose (50 percent kill): 200 mg/kgARZNAD 17,614,1967
oral/rat lethal dose (50 percent kill): 200 mg/kg/24HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TAEHC* VI:34 ,1,1984
oral/woman lowest published lethal dose: 120 µg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Gastrointestinal: Gastritis
CMEP** -,1,1956
skin/human lowest published lethal dose: 428 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
34ZIAG -,648,1969
skin/rabbit lethal dose (50 percent kill): 780 mg/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 690 mg/kgJAVMA4 157,1835,1970
unreported route/human lowest published lethal dose: 25 mg/kg/24HTAEHC* VI:34 ,1,1984
unreported route/man lowest published lethal dose: 118 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 28200 µg/m3/8H/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTEHD6 28,327,1989
inhalation/rat lowest published toxic concentration: 10 mg/m3/8H/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Ca
JTEHD6 28,327,1989
intraperitoneal/rat lowest published toxic dose: 125 mg/kg/5D- intermittentLiver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other
ENDOAO 82,406,1968
intraperitoneal/rat lowest published toxic dose: 500 mg/kg/10D- intermittentEndocrine: Androgenic

Endocrine: Estrogenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
CLPTAT 14,727,1976
oral/rat lowest published toxic dose: 7 mg/kg/28D- intermittentImmunological Including Allergic: Decrease in cellular immune responseTOXID9 60,22,2001
oral/rat lowest published toxic dose: 168 mg/kg/21D- intermittentEndocrine: Other changes

Blood: Changes in spleen
TOXID9 1,54,2001
oral/rat lowest published toxic dose: 21 mg/kg/21D- intermittentLiver: Other changes

Liver: Changes in liver weight
TOXID9 1,54,2001
oral/rat lowest published toxic dose: 176 mg/kg/22D- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOXID9 60,233,2001
oral/rat lowest published toxic dose: 176 mg/kg/22D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,233,2001
oral/rat lowest published toxic dose: 44 mg/kg/22D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 60,233,2001
oral/rat lowest published toxic dose: 28 mg/kg/14D- intermittentEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,247,2001
oral/rat lowest published toxic dose: 22 mg/kg/22D- intermittentLiver: Changes in liver weightTOXID9 60,233,2001
oral/rat lowest published toxic dose: 44 mg/kg/22D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TOXID9 60,233,2001
oral/rat lowest published toxic dose: 660 mg/kg/15D- intermittentBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 7,197,1953
oral/rat lowest published toxic dose: 6512 mg/kg/58W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 7,197,1953
oral/rat lowest published toxic dose: 5475 mg/kg/2Y- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 6,357,1952
oral/rat lowest published toxic dose: 112 mg/kg/14D- intermittentBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 60,247,2001
oral/rat lowest published toxic dose: 112 mg/kg/14D- intermittentEndocrine: Changes in thymus weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 60,247,2001
oral/rat lowest published toxic dose: 224 mg/kg/14D- intermittentLung, Thorax, or Respiration: Respiratory depressionTOXID9 60,247,2001
oral/rat lowest published toxic dose: 410 mg/kg/39W- continuousLiver: Other changesAMPLAO 64,614,1957
oral/rat lowest published toxic dose: 504 mg/kg/12W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APTOD9 19,A99,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,146,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 20,45,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,115,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 53,115,1991
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWBNYMAM 54,413,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWNETOX* 26,531,2005
TOXICOLOGY REVIEWENTOX* -,540,2005
TOXICOLOGY REVIEWENTOX* -,334,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWIMEMDT 79,411,
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNTAPM* -,711,1995
TOXICOLOGY REVIEWREPTED 31,327,2011
TOXICOLOGY REVIEWMUREAV 762,37,2014
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXAPA9 268,157,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,96,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg/m3 (skin)DTLVS* 3,44,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, short term exposure limit 3 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 mg/m3;KZW 5 mg/m3, inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, skin, carc, MAY2011
Occupational Exposure Limit-FRANCEVME 0.5 mg/m3, Skin, C3 Carcinogen, FEB2006
Occupational Exposure Limit-GERMANYMAK 0.5 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYSkin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, skin, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg/m3, short term exposure limit 2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3;short term exposure limit 2 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.01 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, carc 3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg/m3 (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORDANE-air10H Carcinogen time-weighted average 0.5 mg/m3 (Sk)NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100111/AS)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-8,1977
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-8,1977
NIOSH Analytical Method, 1994: Chlordane, 5510
On EPA IRIS database
OSHA ANALYTICAL METHOD #67
TOP