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Registry of Toxic Effects of Chemical Substances (RTECS)

Methanesulfenyl chloride, trichloro-

RTECS #

PB0370000

CAS #

594-42-3

Updated

September 2013

Molecular Weight

185.87

Molecular Formula

CCl4S

Synonyms

Clairsit
Mercaptan methylique perchlore (French)
Perchlormethylmerkaptan (Czech)
Perchloromethyl mercaptan
Perchloromethyl mercaptan (ACGIH:OSHA)
RCRA waste number P118
Trichloromethane sulfenyl chloride
Trichloromethanesulphenyl chloride
Trichloromethylsulfenyl chloride
Trichloromethylsulphenyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe28ZPAK -,13,1972
skin /rabbit 500 mg/24H severe28ZPAK -,13,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 296 mg/m3/2H85GMAT -,97,1982
inhalation/rat lethal concentration (50 percent kill): 11 ppm/1HTXAPA9 42,417,1977
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
NTIS** OTS0533569
intraperitoneal/rat lethal dose (50 percent kill): 25 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0533569
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgCSLNX* NX#06768
oral/mouse lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0533569
oral/rat lethal dose (50 percent kill): 82600 µg/kg28ZPAK -,13,1972
skin/guinea pig lethal dose (50 percent kill): 500 µL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0533569
skin/rabbit lethal dose (50 percent kill): 1410 mg/kgTXAPA9 42,417,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 1 ppm/8H/13W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting
NTIS** OTS0558749
inhalation/guinea pig lowest published toxic concentration: 1 ppm/8H/13W- intermittentEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory stimulation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0558749
inhalation/rat lowest published toxic concentration: 1 ppm/8H/13W- intermittentLung, Thorax, or Respiration: Other changesNTIS** OTS0558749

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.8 mg/m3)DTLVS* 3,202,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.76 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.8 mg/m3);KZW 0.2 ppm (1.6 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.77 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.8 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.1 ppm (0.77 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.8 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.8 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.8 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.76 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,76 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.8 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.8 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.8 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.8 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.8 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.8 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.8 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PERCHLOROMETHYL MERCAPTAN-air10H time-weighted average 0.1 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 54800; Number of Industries 6; Total Number of Facilities 324; Number of Occupations 17; Total Number of Employees Exposed 9112; Total Number of Female Employees Exposed 1677

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8978;8EHQ-0892-9092
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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