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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, dichlorofluoro-

RTECS #

PA8400000

CAS #

75-43-4

Updated

September 2013

Molecular Weight

102.92

Molecular Formula

CHCl2F

Synonyms

Algofrene type 5
Arcton 7
CFC-21
Dichlorofluoromethane
Dichlorofluoromethane (ACGIH)
Dichloromonofluoromethane (OSHA)
Dwuchlorofluorometan (Polish)
FC-21
Fluorocarbon 21
Fluorodichloromethane
Freon 21
Genetron 21
Racon 21
Refrigerant 21

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1 pph/6H (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)TXAPA9 45,293,1978
inhalation/rat 30 mg/m3 (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathVCVGH* -,614,1990
inhalation/rat 100 mg/m3 (1-22D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
VCVGH* -,614,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 1 pph/10MBehavioral: Excitement

Cardiac: EKG changes not diagnostic of above

Kidney, Ureter, and Bladder: Incontinence
EPASR* #86-890000758
inhalation/guinea pig Lowest published lethal concentration: 10 pph/1HFLCRAP 1,197,1967
inhalation/guinea pig Lowest published lethal concentration: 260400 mg/m3/5MVCVGH* -,614,1990
inhalation/mouse lowest published toxic concentration: 868000 mg/m3Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
VCVGH* -,614,1990
inhalation/mouse lethal concentration (50 percent kill): 800000 mg/m3/4HVCVGH* -,614,1990
inhalation/mouse lethal concentration (50 percent kill): >800 gm/m3/2HBehavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
GTPZAB 20(11),38,1976
inhalation/rat lethal concentration (50 percent kill): 49900 ppm/4H85INA8 5,187,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 1 pph/3.5H/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
ZAARAM 21,149,1971
inhalation/Dog lowest published toxic concentration: 1 pph/3.5H/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
ZAARAM 21,149,1971
inhalation/Dog lowest published toxic concentration: 5000 ppm/6H/13W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0520832
inhalation/guinea pig lowest published toxic concentration: 1 pph/3.5H/4W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ZAARAM 21,149,1971
inhalation/rat lowest published toxic concentration: 1 pph/6H/2W- intermittentLiver: Other changesTXAPA9 41(1),199,1977
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/90D- intermittentSkin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 41(1),200,1977

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAZMAE 18,365,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (4200 mg/m3)DTLVS* 3,81,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (42 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (43 mg/m3);KZW 40 ppm (172 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (43 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (40 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (40 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (43 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 43 mg/m3, short term exposure limit 172 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (40 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (40 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 500 ppm (2100 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (42 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (42 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (42 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 40 mg/m3, MAC(short term exposure limit) 200 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (40 mg/m3), KZG-week 20 ppm (80 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 43 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (4200 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (4200 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (43 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (4200 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (4200 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (4200 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (4200 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROMONOFLUOROMETHANE-air10H time-weighted average 10 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24235; Number of Industries 8; Total Number of Facilities 935; Number of Occupations 13; Total Number of Employees Exposed 12182; Total Number of Female Employees Exposed 1640
National Occupational Hazard Survey 1974Hazard Code 24235; Number of Industries 44; Total Number of Facilities 4131; Number of Occupations 56; Total Number of Employees Exposed 43521

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dichlorofluoromethane, 2516
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