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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromotrifluoro-

RTECS #

PA5425000

CAS #

75-63-8

Updated

September 2013

Molecular Weight

148.92

Molecular Formula

CBrF3

Synonyms

Bromofluoroform
Bromotrifluoromethane
Daiflon 13B1
F-13B1
FE 1301
Flugex 13B1
Freon 13B1
Halon 1301
R 13B1
Refrigerant 13B1
Trifluorobromomethane
Trifluorobromomethane (ACGIH:OSHA)
Trifluoromonobromomethane

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lethal concentration: >30 pph/15MBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0571524
inhalation/Dog lowest published toxic concentration: 1662 gm/m3/45MBlood: Other changesVCVGH* -,625,1990
inhalation/Dog lowest published toxic concentration: 1330 gm/m3/20SBehavioral: Convulsions or effect on seizure threshold

Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section
VCVGH* -,625,1990
inhalation/guinea pig lethal concentration (50 percent kill): 88000 ppm/15M85INA8 6,1640,1991
inhalation/human lowest published toxic concentration: 997.5 gm/m3/1MBehavioral: AtaxiaVCVGH* -,626,1990
inhalation/human lowest published toxic concentration: 399 gm/m3/3MPeripheral Nerve and Sensation: Paresthesia

Behavioral: Ataxia

Behavioral: Headache
VCVGH* -,626,1990
inhalation/man Lethal concentration: >15 pph/1MBehavioral: Hallucinations, distorted perceptions

Cardiac: Pulse rate increased without fall in BP
NTIS** OTS0571524
inhalation/monkey lowest published toxic concentration: 2660 gm/m3/2MBehavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic
VCVGH* -,625,1990
inhalation/monkey lowest published toxic concentration: 1330 gm/m3/15MBehavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic
VCVGH* -,625,1990
inhalation/mouse lethal concentration (50 percent kill): 350 gm/m3/2HVCVGH* -,625,1990
inhalation/mouse lethal concentration (50 percent kill): 381 gm/m3GTPZAB 26(8),53,1982
inhalation/rat lethal concentration (50 percent kill): 84000 ppm/15M85INA8 6,1640,1991
inhalation/rat Lowest published lethal concentration: 5054 gm/m3/15MVCVGH* -,625,1990
inhalation/rat lowest published toxic concentration: 4056 gm/m3/2MBehavioral: General anestheticVCVGH* -,625,1990
inhalation/rat lowest published toxic concentration: 2128 gm/m3/12MBehavioral: General anestheticVCVGH* -,625,1990
inhalation/rat lethal concentration (50 percent kill): 430 gm/m3/4HVCVGH* -,625,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (6100 mg/m3)DTLVS* 3,268,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (6090 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (6100 mg/m3);KZW 2000 ppm (12200 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (6178 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1000 ppm (6100 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (6200 mg/m3), short term exposure limit 1300 ppm (8000 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (6100 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (6200 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1000 ppm (6100 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (6100 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (6100 mg/m3);short term exposure limit 1200 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (6090 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (6091 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (6100 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 6100 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (6100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (6100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (6100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (6100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIFLUOROBROMOMETHANE-air10H time-weighted average 1000 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0424; Number of Industries 1; Total Number of Facilities 32; Number of Occupations 1; Total Number of Employees Exposed 32

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromotrifluoromethane, 1017
NIOSH Analytical Method, 1994: Trifluorobromomethane, 1017
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