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Registry of Toxic Effects of Chemical Substances (RTECS)

Manganese, tricarbonyl methylcyclopentadienyl

RTECS #

OP1450000

CAS #

12108-13-3

Updated

April 2015

Molecular Weight

218.10

Molecular Formula

C9H7MnO3

Synonyms

2-Methylcyclopentadienyl manganese tricarbonyl
2-Methylcyclopentadienyl manganese tricarbonyl (ACGIH)
AK-33X
Antiknock-33
CI-2
Combustion improver -2
Manganese, (methylcyclopentadienyl)tricarbonyl-
Methylcyclopentadienyl manganese tricarbonyl
Methylcyklopentadientrikarbonylmanganium (Czech)
MMT
Tricarbonyl(methylcyclopentadienyl)manganese

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H mildAEHLAU 30,168,1975

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 90 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV298 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 223 mg/m3/7HTMMT** -,-,1976
inhalation/Dog Lowest published lethal concentration: 489 mg/m3/2HTMMT** -,-,1976
inhalation/guinea pig Lowest published lethal concentration: 411 mg/m3/7HTMMT** -,-,1976
inhalation/mouse lethal concentration (50 percent kill): 58600 µg/m3/4HSAIGBL 20,553,1978
inhalation/rabbit Lowest published lethal concentration: 411 mg/m3/7HTMMT** -,-,1976
inhalation/rat lethal concentration (50 percent kill): 76 mg/m3/4HEye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 40,164,1979
inhalation/rat lethal concentration (50 percent kill): 247 mg/m3/1HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV298 -,-,2003
inhalation/rat lethal concentration (50 percent kill): 76 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV298 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 152 mg/kgBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
SKIZAB 34,183,1978
intraperitoneal/rat lethal dose (50 percent kill): 12 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
TOLED5 39,1,1987
intravenous/Dog lowest published lethal dose: 10 mg/kgTMMT** -,-,1976
intravenous/rabbit lethal dose (50 percent kill): 6600 µg/kgTMMT** -,-,1976
oral/Dog lowest published lethal dose: 620 mg/kgTMMT** -,-,1976
oral/guinea pig lethal dose (50 percent kill): 905 mg/kgTMMT** -,-,1976
oral/mouse lethal dose (50 percent kill): 34 mg/kgNICHAS 44,173,1985
oral/rabbit lethal dose (50 percent kill): 95 mg/kgTMMT** -,-,1976
oral/rat lethal dose (50 percent kill): 58 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
HPV298 -,-,2003
oral/rat lethal dose (50 percent kill): 8 mg/kgTMMT** -,-,1976
skin/rabbit lethal dose (50 percent kill): 140 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Blood: Hemorrhage

Skin: After topical application: Primary irritation
HPV298 -,-,2003
skin/rabbit lethal dose (50 percent kill): 140 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 40,164,1979
skin/rat lethal dose (50 percent kill): 665 mg/kgTMMT** -,-,1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/monkey lowest published toxic concentration: 30200 µg/m3/14W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionHPV298 -,-,2003
inhalation/mouse lowest published toxic concentration: 3500 µg/m3/14W- intermittentLung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV298 -,-,2003
inhalation/rat lowest published toxic concentration: 300 µg/m3/14W- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HPV298 -,-,2003
inhalation/rat lowest published toxic concentration: 3500 µg/m3/14W- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV298 -,-,2003
oral/mouse lowest published toxic dose: 75426 mg/kg/1Y- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AECTCV 23,473,1992

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg(Mn)/m3 (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAMRL** TR-73-125,1973
TOXICOLOGY REVIEW85DHAX Mn,126,1973
TOXICOLOGY REVIEWNRTXDN 31,555,2010
TOXICOLOGY REVIEWMUREAV 762,76,2014

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.2 mg/m3) (skin)DTLVS* 3,164,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Mn)/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.2 mg(Mn)/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg(Mn)/m3, short term exposure limit 0.6 mg(Mn)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg(Mn)/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.2 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg(Mn)/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,2 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.2 mg(Mn)/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 0.2 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84547; Number of Industries 2; Total Number of Facilities 65; Number of Occupations 5; Total Number of Employees Exposed 4891
National Occupational Hazard Survey 1974Hazard Code 84547; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 1; Total Number of Employees Exposed 34

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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