Manganese

RTECS #

OO9275000

CAS #

7439-96-5
See: NMAM or OSHA Methods

Updated

September 2018

Molecular Weight

54.94

Molecular Formula

Synonyms

Colloidal manganese
Magnacat
Mangan (Polish)
Mangan nitridovany (Czech)
Manganese (ACGIH:OSHA)
Tronamang

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	28ZPAK -,21,1972
skin /rabbit	500 mg/24H	mild	28ZPAK -,21,1972

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Dominant Lethal Test	intraperitoneal/rat	25 mg/kg	VCVN5* -,413,1989

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	0.71 mg/m³ (15-16D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	NRTXDN 27,395,2006
inhalation/rat	0.71 mg/m³ (multigeneration)	Reproductive: Effects on newborn: Biochemical and metabolic	NRTXDN 27,395,2006
oral/rat	90 mg/kg (18D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects	TOSCF2 92,516,2006
oral/rat	50 mg/kg (20D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral	NRTXDN 23,635,2002
oral/mouse	322.5 mg/kg (43D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	REPTED 17,547,2003
oral/mouse	1290 mg/kg (43D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	REPTED 17,547,2003

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intramuscular/rat	lowest published toxic dose: 400 mg/kg/1Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	NCIUS* PH43-64-886

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/man	lowest published toxic concentration: 2300 µg/m³	Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Behavioral: Muscle weakness	AIHAAP 27,454,1966
oral/rat	lethal dose (50 percent kill): 9 gm/kg		28ZPAK -,21,1972
Tank with water/Daphnia	lethal concentration (50 percent kill): 5700 µg/L/48H		TIVIEQ 31,125,1995

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 250 mg/m³/1Y- intermittent	Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Irritability Lung, Thorax, or Respiration: Other changes	VCVN5* -,413,1989
inhalation/human	lowest published toxic concentration: 0.5 mg/m³/39W- intermittent	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Behavioral: Irritability	VCVN5* -,413,1989
inhalation/human	lowest published toxic dose: >0.1 mg/kg/1Y- intermittent	Behavioral: Change in motor activity (specific assay)	TOXID9 -,144,2008
inhalation/man	lowest published toxic concentration: 210 µg/m³/5Y- intermittent	Endocrine: Other changes	ACLSCP 26,10,1996
inhalation/monkey	lowest published toxic concentration: 0.3 mg/m³/5H/26W- intermittent	Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response	VCVN5* -,412,1989
inhalation/mouse	lowest published toxic concentration: 0.7 mg/m³/24H/22W- continuous	Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response	VCVN5* -,412,1989
inhalation/rat	lowest published toxic concentration: 0.71 mg/m³/2H/10D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other proteins	NRTXDN 27,395,2006
inhalation/rat	lowest published toxic concentration: 0.7 mg/m³/24H/22W- continuous	Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response	VCVN5* -,412,1989
inhalation/rat	lowest published toxic concentration: 0.3 mg/m³/5H/26W- intermittent	Lung, Thorax, or Respiration: Fibrosis (interstitial) Immunological Including Allergic: Decrease in cellular immune response	VCVN5* -,412,1989
inhalation/rat	lowest published toxic concentration: 3709 mg/m³/6H/13W- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Other changes	TOXID9 54,85,2000
intraperitoneal/rat	lowest published toxic dose: 180 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Other metals	TOLED5 7,217,1981
intraperitoneal/rat	lowest published toxic dose: 57.6 mg/kg/4W- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests	TOXID9 66,205,2002
intraperitoneal/rat	lowest published toxic dose: 216 mg/kg/15W- intermittent	Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	TOXID9 44,122,2005
intraperitoneal/rat	lowest published toxic dose: 144 mg/kg/5W- intermittent	Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	TOXID9 44,122,2005
oral/child	lowest published toxic dose: 8294 µg/kg/12Y- continuous	Brain and Coverings: Other degenerative changes	NRTXDN 53,124,2016
oral/rat	lowest published toxic dose: 5.25 mg/kg/21D- intermittent	Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	NETEEC 28,323,2006
oral/rat	lowest published toxic dose: 185 mg/kg/37D- continuous	Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	TOSCF2 92,516,2006
oral/rat	lowest published toxic dose: 200 mg/kg/20D- intermittent	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral	NRTXDN 23,645,2002
unreported route/rat	lowest published toxic dose: 24 mg/kg/5W- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Ataxia Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)	TOXID9 78,82,2004
unreported route/rat	lowest published toxic dose: 72 mg/kg/5W- intermittent	Behavioral: Change in motor activity (specific assay)	TOXID9 78,82,2004

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.02 mg/m³ (resp),0.1 mg/m³ (inhal)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TRBMAV 33,85,1975
TOXICOLOGY REVIEW		ACLSCP 4,487,1974
TOXICOLOGY REVIEW		ADTEAS 5,51,1972
TOXICOLOGY REVIEW		FOREAE 7,313,1942
TOXICOLOGY REVIEW		KOTTAM 11,1300,1975
TOXICOLOGY REVIEW		85DHAX Mn,1,1973
TOXICOLOGY REVIEW		PEXTAR 12,102,1969
TOXICOLOGY REVIEW		IMSUAI 24,1,1955
TOXICOLOGY REVIEW		CREOH* 42,25,2002
TOXICOLOGY REVIEW		BCPCA6 66,1,2003
TOXICOLOGY REVIEW		TOLED5 134,17,2002
TOXICOLOGY REVIEW		MUREAV 613,103,2006
TOXICOLOGY REVIEW		NRTXDN 27,147,2006
TOXICOLOGY REVIEW		NRTXDN 27,304,2006
TOXICOLOGY REVIEW		NRTXDN 27,315,2006
TOXICOLOGY REVIEW		NRTXDN 27,333,2006
TOXICOLOGY REVIEW		NRTXDN 27,340,2006
TOXICOLOGY REVIEW		NRTXDN 27,347,2006
TOXICOLOGY REVIEW		NRTXDN 27,350,2006
TOXICOLOGY REVIEW		NRTXDN 27,362,2006
TOXICOLOGY REVIEW		NRTXDN 27,369,2006
TOXICOLOGY REVIEW		NRTXDN 27,429,2006
TOXICOLOGY REVIEW		MUREAV 613,76,2006
TOXICOLOGY REVIEW		REPTED 23,260,2007
TOXICOLOGY REVIEW		ITODC* -,355,2004
TOXICOLOGY REVIEW		HUTOX* -,515,1996
TOXICOLOGY REVIEW		HTOPA* 1,595,2002
TOXICOLOGY REVIEW		MUREAV 674,73,2009
TOXICOLOGY REVIEW		MUREAV 674,137,2009
TOXICOLOGY REVIEW		PTPAD4 113,229,2007
TOXICOLOGY REVIEW		MUREAV 667,82,2009
TOXICOLOGY REVIEW		NEUCL* 23,485,2005
TOXICOLOGY REVIEW		NETEEC 32,16,2010
TOXICOLOGY REVIEW		NTAPM* -,265,1995
TOXICOLOGY REVIEW		NTAPM* -,617,1995
TOXICOLOGY REVIEW		NTAPM* -,629,1995
TOXICOLOGY REVIEW		NTAPM* -,689,1995
TOXICOLOGY REVIEW		NTAPM* -,711,1995
TOXICOLOGY REVIEW		NTAPM* -,727,1995
TOXICOLOGY REVIEW		NTAPM* -,753,1995
TOXICOLOGY REVIEW		NBREV* 15,333,1991
TOXICOLOGY REVIEW		NRTXDN 31,555,2010
TOXICOLOGY REVIEW		NRTXDN 33,178,2012
TOXICOLOGY REVIEW		REPTED 34,298,2012
TOXICOLOGY REVIEW		NRTXDN 43,36,2014
TOXICOLOGY REVIEW		NRTXDN 44,314,2014
TOXICOLOGY REVIEW		TXCYAC 313,3,2013
TOXICOLOGY REVIEW		TXCYAC 323,78,2014
TOXICOLOGY REVIEW		MUREAV 770,140,2016
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		MUREAV 770,170,2016
TOXICOLOGY REVIEW		NRTXDN 56,262,2016
TOXICOLOGY REVIEW		TOLED5 272,8,2017

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	air-ceiling concentration 5 mg/m³	DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³ (dust), JUL2008
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (fume), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.2 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 mg(Mn)/m³ (fume), MAY2011
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 mg/m³ (dust), MAY2011
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³ (respirable), MAY2011
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.2 mg/m³, inhal. dust, NOV2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 mg/m³, resp. dust, NOV2011
Occupational Exposure Limit-FRANCE	VME 1 mg/m³ (fume), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.02 mg(Mn)/m³ (resp), 0.2 mg(Mn)/m³ (inhal), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 5 mg/m³, short term exposure limit 20 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 1 mg/m³ (resp. dust), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.2 mg/m³, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³ (fume), 2006
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³ (dust), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 mg(Mn)/m³, 2004
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 mg(Mn)/m³;short term exposure limit 3 mg(Mn)/m³, 2004
Occupational Exposure Limit-MEXICO	time-weighted average 0.2 mg/m³, 2004
Occupational Exposure Limit-MEXICO	time-weighted average 1 mg(Mn)/m³ (fume), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³ (dust), JAN2002
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³ (fume), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,2 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	time-weighted average 0.1 mg/m³, short term exposure limit 0.6 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.2 mg/m³, (total dust);time-weighted average 0.1 mg/m³, (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 5 mg/m³ (fume), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.5 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	ceiling concentration 5 mg(Mn)/m³, fume	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	ceiling concentration 5 mg(Mn)/m³, fume	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	ceiling concentration 5 mg(Mn)/m³, fume	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	ceiling concentration 5 mg(Mn)/m³, fume	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MANGANESE COMPDS (as Mn)-air	time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X5920; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 305; Total Number of Female Employees Exposed 71
National Occupational Exposure Survey 1983	Hazard Code X5992; Number of Industries 9; Total Number of Facilities 235; Number of Occupations 9; Total Number of Employees Exposed 4560; Total Number of Female Employees Exposed 12
National Occupational Exposure Survey 1983	Hazard Code 44000; Number of Industries 316; Total Number of Facilities 66404; Number of Occupations 125; Total Number of Employees Exposed 756403; Total Number of Female Employees Exposed 15912
National Occupational Hazard Survey 1974	Hazard Code 44000; Number of Industries 29; Total Number of Facilities 1963; Number of Occupations 53; Total Number of Employees Exposed 19787

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108025)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID-125G

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health